Protein Information

Name AT3
Synonyms AT III; AT3; ATIII; Antithrombin III; Antithrombin III precursor; PRO0309; SERPINC 1; SERPINC1…

Compound Information

Name potassium cyanate
CAS potassium cyanate

Reference List

PubMed Abstract RScore(About this table)
2385238 Serebryanyi AM, Sal'nikova LE, Bakhitova LM, Paschin YuV: Role of the carbamoylation reaction in the biological activity of methyl nitrosourea. Mutat Res. 1990 Aug;231(2):195-203.


Besides, pretreatment of cells with potassium cyanate and subsequent exposure to MNU, EMS and benzopyrene (BP) produced synergistic effects in all the tests: lethality, clastogenicity and mutation frequency at the OUAr and TK loci.
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3234752 Sal'nikova LE, Pashin IuV: [Modifying action of carbamoylation reaction on mutagenic and toxic effects of alkylating compounds and heavy metal salts]. Genetika. 1988 Nov;24(11):2088-90.

Using mammalian somatic cells (CHO-AT3-2) we have demonstrated a synergistic effect of ethyl methane sulfonate and a carbamoylating agent, potassium cyanate.
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2717719 Serebrianyi AM, Sal'nikova LE, Bakhitova LM, Pashin IuB: [Potassium cyanate modification of the toxic and mutagenic effects of gamma radiation and benzo (a) pyrene]. Radiobiologiia. 1989 Mar-Apr;29(2):235-40.

In experiments with CHO-AT3-2 cell culture, a study was made of the effect of potassium cyanate (KNCO) on the effect of gamma radiation and benzo (a) pyrene (BP) by the following tests: cell viability, induction of cells with micronuclei and fragmented nuclei and mutations by thymidine kinase (TK) and Na+/K+-ATPase loci.
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