| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | dichlobenil |
|---|---|
| CAS | 2,6-dichlorobenzonitrile |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1884429 | Eriksson C, Brittebo EB: Metabolic activation of the herbicide dichlobenil in the olfactory mucosa of mice and rats. Chem Biol Interact. 1991;79(2):165-77. The covalent binding was dependent on and was inhibited by the addition of dithionite, and indicating an oxidative cytochrome P-450 dependent activation of dichlobenil into an electrophilic intermediate. |
81(1,1,1,1) | Details |
| 8378937 | Walters E, Buchheit K, Maruniak JA: Olfactory cytochrome P-450 immunoreactivity in mice is altered by dichlobenil but preserved by Toxicology. 1993 Jul 28;81(2):113-22. These studies support previous reports that dichlobenil-induced olfactotoxicity is cytochrome P-450 mediated. |
37(0,1,2,2) | Details |
| 16661486 | Reichhart D, Salaun JP, Benveniste I, Durst F: Time Course of Induction of Cytochrome P-450, -Cytochrome c Reductase, and Hydroxylase by Phenobarbital, Herbicides, and in Higher Plant Microsomes. Plant Physiol. 1980 Oct;66(4):600-604. The mixed function oxidase 4-hydroxylase, cytochrome P-450, cytochrome b (5), and -cytochrome c (P-450) reductase were measured in microsomes from aging artichoke tuber slices exposed to phenobarbital, and the herbicides Chloro-IPC, Dichlobenil, and Monuron. |
33(0,1,1,3) | Details |
| 7820883 | Eriksson C, Brittebo EB: Metabolic activation of the olfactory toxicant, dichlobenil, in rat olfactory microsomes: comparative studies with Chem Biol Interact. 1995 Mar 18;94(3):183-96. The tissue-specific toxicity of the herbicide, dichlobenil (2,6-dichlorobenzonitrile), in the olfactory mucosa is related to a cytochrome P450 (P450)-dependent metabolism, depletion of and covalent binding of metabolites. |
31(0,1,1,1) | Details |
| 9385390 | Brittebo EB: Metabolism-dependent activation and toxicity of chemicals in nasal glands. Mutat Res. 1997 Oct 31;380(1-2):61-75. Special attention is put on the herbicide dichlobenil which induces necrosis in the olfactory mucosa following a cytochrome-P450-mediated metabolic activation and covalent binding in the Bowman's glands. |
31(0,1,1,1) | Details |
| 14566026 | Piras E, Franzen A, Fernandez EL, Bergstrom U, Raffalli-Mathieu F, Lang M, Brittebo EB: Cell-specific expression of CYP2A5 in the mouse respiratory tract: effects of olfactory toxicants. J Histochem Cytochem. 2003 Nov;51(11):1545-55. We performed a detailed analysis of mouse cytochrome P450 2A5 (CYP2A5) expression by in situ hybridization (ISH) and immunohistochemistry (IHC) in the respiratory tissues of mice. In contrast, the olfactory toxicants dichlobenil and methimazole induced characteristic changes. |
1(0,0,0,1) | Details |
| 16221755 | Franzen A, Carlsson C, Hermansson V, Lang M, Brittebo EB: CYP2A5-mediated activation and early ultrastructural changes in the olfactory mucosa: studies on 2,6-dichlorophenyl methylsulfone. Drug Metab Dispos. 2006 Jan;34(1):61-8. Epub 2005 Oct 12. The aim of the present study was to examine cytochrome P450 (P450)-dependent bioactivation, nonprotein sulfhydryl (NP-SH) levels, and early ultrastructural changes in mouse olfactory mucosa following an i.p. injection of 2,6-diClPh-MeSO2 (32 mg/kg). A high covalent binding of 2,6-diClPh-14C-MeSO2 in olfactory mucosa S9 fraction was observed, and the CYP2A5/CYP2G1 substrates and dichlobenil significantly decreased the binding, whereas the CYP2E1 substrate chlorzoxazone had no effects. |
1(0,0,0,1) | Details |
| 2339421 | Brandt I, Brittebo EB, Feil VJ, Bakke JE: Irreversible binding and toxicity of the herbicide dichlobenil (2,6-dichlorobenzonitrile) in the olfactory mucosa of mice. Toxicol Appl Pharmacol. 1990 May;103(3):491-501. In mice pretreated with the binding decreased markedly, indicating that the reactive metabolite was formed by a cytochrome P450-dependent mechanism. |
1(0,0,0,1) | Details |
| 8619240 | Eriksson C, Busk L, Brittebo EB: 3-Aminobenzamide: effects on cytochrome P450-dependent metabolism of chemicals and on the toxicity of dichlobenil in the olfactory mucosa. Toxicol Appl Pharmacol. 1996 Feb;136(2):324-31. |
162(2,2,2,2) | Details |
| 8590028 | Delaleu JC, Sicard G: Physiological and histological recovery of the olfactory mucosa of the frog after a dichlobenil injection. Chem Senses. 1995 Aug;20(4):433-40. Pretreatment of the animals with an inhibitor of cytochrome P-450 enzymatic systems, inhibits the histological and physiological toxic effects of the dichlobenil injection. |
81(1,1,1,1) | Details |