| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | glyphosate |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9514851 | Lamb DC, Kelly DE, Hanley SZ, Mehmood Z, Kelly SL: Glyphosate is an inhibitor of plant cytochrome P450: functional expression of Thlaspi arvensae cytochrome P45071B1/reductase fusion protein in Escherichia coli. Biochem Biophys Res Commun. 1998 Mar 6;244(1):110-4. |
162(2,2,2,2) | Details |
| 19603180 | Yu Q, Abdallah I, Han H, Owen M, Powles S: Distinct non-target site mechanisms endow resistance to glyphosate, ACCase and ALS-inhibiting herbicides in multiple herbicide-resistant Lolium rigidum. Planta. 2009 Sep;230(4):713-23. Epub 2009 Jul 15. Glyphosate resistance is due to reduced rates of glyphosate translocation, and resistance to ACCase and ALS herbicides is likely due to enhanced herbicide metabolism involving different cytochrome P450 enzymes. |
82(1,1,1,2) | Details |
| 15627243 | Xiang WS, Wang XJ, Ren TR, Ju XL: Expression of a wheat cytochrome P450 monooxygenase in yeast and its inhibition by glyphosate. Pest Manag Sci. 2005 Apr;61(4):402-6. The addition of glyphosate to the microsomal protein resulted in a Type II spectrum indicative of binding via the group to haem of cytochrome P450 as a sixth ligand. |
81(1,1,1,1) | Details |
| 6624478 | Hietanen E, Linnainmaa K, Vainio H: Effects of phenoxyherbicides and glyphosate on the hepatic and intestinal biotransformation activities in the rat. Acta Pharmacol Toxicol. 1983 Aug;53(2):103-12. Glyphosate decreased the hepatic level of cytochrome P-450 and monooxygenase activities and the intestinal activity of aryl hydrocarbon hydroxylase. |
6(0,0,1,1) | Details |
| 10964798 | Walsh LP, McCormick C, Martin C, Stocco DM: Roundup inhibits steroidogenesis by disrupting steroidogenic acute regulatory (StAR) protein expression. Environ Health Perspect. 2000 Aug;108(8):769-76. StAR protein mediates the rate-limiting and acutely regulated step in steroidogenesis, the transfer of from the outer to the inner mitochondrial membrane where the cytochrome P450 side chain cleavage (P450scc) enzyme initiates the synthesis of all steroid hormones. |
1(0,0,0,1) | Details |
| 20183062 | Abass K, Turpeinen M, Pelkonen O: An evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomes. J Environ Sci Health B. 2009 Aug;44(6):553-63. Some pesticides caused relatively potent inhibitions sporadically (carbendazim, CYP2D6, IC (50) = 12 micro M; atrazine, CYP3A4, IC (50) = 2.8 micro M; glyphosate, CYP2C9, IC (50) = 3.7 micro M; hexaflumuron, IC (50) = 6.0 micro M). |
1(0,0,0,1) | Details |
| 10918358 | Kaya B, Creus A, Yanikoglu A, Cabre O, Marcos R: Use of the Drosophila wing spot test in the genotoxicity testing of different herbicides. Environ Mol Mutagen. 2000;36(1):40-6. Four herbicides, namely propanil, maleic hydrazide, glyphosate, and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), were investigated for genotoxicity in the wing spot test of Drosophila melanogaster. The HB cross uses flies characterized by an increased cytochrome P-450-dependent bioactivation capacity, which permits a more efficient biotransformation of promutagens and procarcinogens. |
1(0,0,0,1) | Details |