| Name | endothelin 1 |
|---|---|
| Synonyms | EDN 1; EDN1; ET1; Endothelin 1; Endothelin 1 precursor; PPET 1; PPET1; Preproendothelin 1… |
| Name | chloralose |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7485504 | Wood JG, Yan ZY, Zhang Q, Cheung LY: Ischemia-reperfusion increases gastric motility and endothelin-1-induced vasoconstriction. Am J Physiol. 1995 Oct;269(4 Pt 1):G524-31. These experiments used a mechanically perfused ex vivo gastric segment of chloralose-anesthetized dogs. |
2(0,0,0,2) | Details |
| 10665982 | Yakubu MA, Leffler CW: Enhanced pial arteriolar sensitivity to bioactive agents following exposure to endothelin-1. Life Sci. 2000;66(4):307-16. Piglets (age: 1-3 d) anesthetized with a mixture of ketamine hydrochloride and acepromazine were implanted with cranial windows, and anesthesia was maintained with alpha-chloralose. |
2(0,0,0,2) | Details |
| 9335407 | Dai SM, Shan ZZ, Miao CY, Yin M, Su DF: Hemodynamic responses to endothelin-1 and endothelin antagonists microinjected into the nucleus tractus solitarius in rats. J Cardiovasc Pharmacol. 1997 Oct;30(4):475-80. The arterial baroreflex sensitivity was almost totally suppressed by microinjection of ET-1 (3.3 pmol) in alpha-chloralose-anesthetized Sprague-Dawley rats. |
2(0,0,0,2) | Details |
| 8760103 | Wood JG, Zhang Q, Yan ZY, Cheung LY: attenuates endothelin-1-induced vasoconstriction in canine stomach. Am J Physiol. 1996 Jul;271(1 Pt 1):G27-35. Using a mechanically perfused stomach segment from chloralose-anesthetized dogs, we examined 1) responses to NG-nitro- methyl ester (L-NAME) alone and in combination with 2) whether L-NAME affects ET-1-induced vasoconstriction under normal conditions and after ischemia-reperfusion, and 3) if -N-[4-1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazi no] butyl; a donor} attenuates the augmented response to ET-1 after ischemia-reperfusion. |
2(0,0,0,2) | Details |
| 7877876 | Yakubu MA, Shibata M, Leffler CW: Subarachnoid hematoma attenuates vasodilation and potentiates vasoconstriction induced by vasoactive agents in newborn pigs. Pediatr Res. 1994 Nov;36(5):589-94. The effects of perivascular blood on pial arteriolar vasoreactivity to selected vasodilators and vasoconstrictors were examined in vivo in a newborn pig model. alpha-Chloralose-anesthetized newborn pigs were fitted with closed cranial windows 4 d after cortical subarachnoid injections of autologous blood. The responsiveness of pial arterioles to topical application of dilator agents [iloprost, and sodium nitroprusside (SNP)] and vasoconstrictor agents and endothelin-1 (ET-1) in artificial cerebrospinal fluid was studied in control and blood-injected piglets. |
1(0,0,0,1) | Details |
| 8896820 | Yakubu MA, Leffler CW: Role of endothelin-1 in cerebral hematoma-induced modification of cerebral vascular reactivity in piglets. Brain Res. 1996 Sep 23;734(1-2):149-56. Closed cranial windows were implanted in alpha-chloralose anesthetized piglets 4 days following cortical subarachnoid injection of: (1) artificial cerebrospinal fluid (aCSF); (2) autologous blood; (3) BQ-123 alone; or (4) BQ-123 in combination with blood. |
2(0,0,0,2) | Details |
| 7478789 | Yakubu MA, Shibata M, Leffler CW: Hematoma-induced enhanced cerebral vasoconstrictions to and endothelin-1 in piglets: role of prostanoids. Pediatr Res. 1995 Jul;38(1):119-23. Newborn pigs anesthetized with alpha-chloralose were fitted with closed cranial windows 4 d after cortical subarachnoid injections of artificial cerebrospinal fluid (aCSF) (control) or blood (hematoma). |
2(0,0,0,2) | Details |
| 8796118 | Cinca J, Mont L, Carreno A, Mourelle M, Rodes J, Domingo A, Soler-Soler J: Coronary denervation attenuates coronary constriction induced by muscarinic receptor stimulation in pigs. Cardiovasc Res. 1996 Aug;32(2):311-9. METHODS: Heart rate, left ventricular (LV) pressure, LV dP/dt, coronary blood flow at the left anterior descending (LAD) coronary artery, and epicardial ECG mapping were measured before and after topical application of 1% methacholine to the LAD in 10 pigs anesthetized with alpha-chloralose (100 mg/kg, i.v.); these were compared with 10 other pigs submitted 2 weeks previously to a denervation of the LAD with Isolated LAD rings from 10 additional pigs (5 controls and 5 treated with were stimulated with endothelin-1 to verify whether affected coronary reactivity to noncholinergic stimulation. |
2(0,0,0,2) | Details |
| 8964810 | Goadsby PJ, Adner M, Edvinsson L: Characterization of endothelin receptors in the cerebral vasculature and their lack of effect on spreading depression. J Cereb Blood Flow Metab. 1996 Jul;16(4):698-704. For the physiological studies, cats were anesthetized with halothane induction and alpha-chloralose (60 mg/kg, intraperitoneal loading; 20 mg/kg i.v. 2-h maintenance). The in vitro work demonstrated that endothelin-1 (ET-1) mediates a strong and potent contraction of cerebral vessels. |
1(0,0,0,1) | Details |
| 8564881 | Notarius CF, Erice F, Stewart D, Magder S: Effect of baroreceptor activation and systemic hypotension on plasma endothelin 1 and neuropeptide Y. Can J Physiol Pharmacol. 1995 Aug;73(8):1136-43. To determine whether endothelin (ET-1) and neuropeptide Y (NPY) release are controlled by the carotid sinus (CS) baroreceptor or local endothelial mechanisms, we isolated and pump perfused the CS in eight chloralose-anesthetized dogs and controlled systemic arterial pressure (SAP) with an elevated reservoir connected to both femoral arteries. |
1(0,0,0,1) | Details |
| 14988085 | Stocker SD, Schiltz JC, Sved AF: Acute increases in arterial blood pressure do not reduce plasma levels stimulated by angiotensin II or hyperosmolality in rats. Am J Physiol Regul Integr Comp Physiol. 2004 Jul;287(1):R127-37. Epub 2004 Feb 26. In alpha-chloralose-anesthetized rats infused with hypertonic saline, inflation of an aortic cuff to increase ABP and stimulate arterial baroreceptors did not reduce plasma VP levels. |
0(0,0,0,0) | Details |
| 8141304 | Wood JG, Yan ZY, Davis JM, Cheung LY: Phosphoramidon attenuates big endothelin-1-induced vasoconstriction in canine stomach. Am J Physiol. 1994 Feb;266(2 Pt 1):G311-7. We compared the effects of endothelin-1 and its precursor, big endothelin-1, on vascular resistance of a blood-perfused ex vivo stomach segment of chloralose-anesthetized dogs. |
12(0,0,1,7) | Details |
| 9403795 | Krowicki ZK, Hornby PJ: Evidence for a dual mechanism of gastric motor responses to intravenously administered endothelin-1 in anesthetized rats. J Physiol Paris. 1997 May-Oct;91(3-5):203-7. To determine whether circulating ET-1 acts peripherally or centrally to alter gastric motility, ET-1 (30 and 300 pmol/kg) was administered intravenously in alpha-chloralose anesthetized rats, while monitoring intragastric pressure, gastric motility, heart rate and blood pressure. |
3(0,0,0,3) | Details |