| Name | 5 HT3 receptor |
|---|---|
| Synonyms | 5 HT 3; 5 hydroxytryptamine 3 receptor; serotonin receptor; HTR 3; HTR3; 5 HT3; 5 HT3A; 5 HT3R… |
| Name | chloralose |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12088752 | Nosjean A, Callera JC, Bonagamba L, Machado B, Hamon M, Laguzzi R: (3) receptor stimulation in the nucleus tractus solitarii activates non-catecholaminergic neurons in the rat ventrolateral medulla. Neuroscience. 2002;112(4):935-49. For this purpose, double immunohistochemical labeling for tyrosine hydroxylase and c-fos protein was performed all along the ventrolateral medulla after microinjection of 1-(m-chlorophenyl)-biguanide, a selective and potent 5-HT (3) receptor agonist, into the nucleus tractus solitarii of alpha-chloralose/urethane-anaesthetized rats. |
82(1,1,1,2) | Details |
| 9680249 | Bootle DJ, Adcock JJ, Ramage AG: The role of central receptors in the bronchoconstriction evoked by inhaled in anaesthetised guinea-pigs. Neuropharmacology. 1998;37(2):243-50. The effects of intracisternal (i.c) injections of the 5-HT1A receptor agonists, and 8-OH-DPAT, and the antagonists WAY-100635; and (-)-pindolol, the 5-HT1B/1D receptor agonist and antagonist GR127935, the 5-HT2 receptor agonist DOI and the antagonist cinanserin, the 5-HT3 receptor antagonist granisetron, the alpha-adrenoceptor agonist clonidine and the antagonist idazoxan, the D2 receptor antagonists (-)-sulpiride and the uptake inhibitor fluoxetine on -evoked increase in tracheal inflation pressure (bronchoconstriction) were investigated in alpha-chloralose anaesthetised, neuromuscularly blocked, artificially ventilated guinea-pigs. |
31(0,1,1,1) | Details |
| 7907142 | Neya T, Mizutani M, Yamasato T: Role of 5-HT3 receptors in peristaltic reflex elicited by stroking the mucosa in the canine jejunum. J Physiol. 1993 Nov;471:159-73. The role played by the 5-HT3 receptor, a subtype receptor, in peristaltic reflexes was studied in dogs first given ketamine, then anaesthetized with urethane (1.0 g kg-1, I.V.) and alpha-chloralose (100 mg kg-1, I.V.). |
34(0,1,1,4) | Details |
| 9087599 | Sevoz C, Callera JC, Machado BH, Hamon M, Laguzzi R: Role of serotonin3 receptors in the nucleus tractus solitarii on the carotid chemoreflex. Am J Physiol. 1997 Mar;272(3 Pt 2):H1250-9. The effects of serotonin3 (5-HT3)-receptor stimulation in the nucleus tractus solitarii (NTS) on the cardiovagal, sympathetic, and respiratory responses to activation of carotid body chemoreceptors were investigated in anesthetized rats. The chemoreflex responses were triggered by an intravenous administration of KCN (40 microg/kg) in spontaneously breathing urethan-chloralose-anesthetized rats or by an intracarotid administration of saline saturated with 100% CO2 in pancuronium bromide-paralyzed and artificially ventilated urethan-anesthetized rats. |
5(0,0,0,5) | Details |
| 12770947 | Saita M, Verberne AJ: Roles for CCK1 and 5-HT3 receptors in the effects of CCK on presympathetic vasomotor neuronal discharge in the rat. Br J Pharmacol. 2003 May;139(2):415-23. 1 The role of peripheral (5-HT (3)) receptors and cholecystokinin type 1 (CCK (1)) receptors in the inhibitory effects of phenylbiguanide (PBG) and CCK on arterial blood pressure, heart rate and the discharge of presympathetic vasomotor neurones of the rostral ventrolateral medulla (RVLM) was studied in alpha-chloralose-anaesthetized rats. 2 CCK (1 and 4 micro g kg (-1), i.v.) and PBG (2 and 10 micro g kg (-1), i.v.) reduced arterial blood pressure and heart rate, and inhibited the discharge of single RVLM presympathetic vasomotor neurones in a dose-related manner. 3 Devazepide (0.5 mg kg (-1), i.v.), a selective CCK (1) receptor antagonist, blocked the effects of CCK on arterial blood pressure, heart rate and neuronal discharge but did not significantly alter these responses to PBG. |
5(0,0,0,5) | Details |
| 16357061 | Kordasti S, Sapnara M, Thomas EA, Lindstrom E, Forsman M, Bornstein JC, Sjovall H: Effects of cholera toxin on the potential difference and motor responses induced by distension in the rat proximal small intestine in vivo. Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G948-58. Epub 2005 Dec 15. This hypothesis was tested in chloralose-anesthetized rats in vivo. In controls, distension increased PD, and this response was reduced by the neural blocker tetrodotoxin given serosally and the vasoactive intestinal peptide (VIP) receptor antagonist [4Cl-d- (6),Leu (17)] VIP (2 mug.min (-1).kg (-1) iv) but unaffected by the serotonin 5-HT (3) receptor antagonist granisetron, by the nicotinic receptor antagonist hexamethonium, by the muscarinic receptor antagonist atropine, or by the cyclooxygenase inhibitor indomethacin. |
2(0,0,0,2) | Details |
| 8097247 | Krowicki ZK, Hornby PJ: microinjected into the nucleus raphe obscurus increases intragastric pressure in the rat via a vagally mediated pathway. J Pharmacol Exp Ther. 1993 Apr;265(1):468-76. The purpose of the present study was to investigate the effect of microinjection of and selected receptor subtype agonists and antagonists into the caudal nucleus raphe obscurus on gastrointestinal motor activity in urethane-chloralose anesthetized rats. Microinjection of a 5-HT1A receptor agonist, 8--N,N-dipropyl-2-amino-tetralin hydrobromide (0.06-12.0 nmol), a 5-HT1C/2 receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (4.5 and 18.0 nmol), as well as a 5-HT3 receptor agonist, 1-(m-chlorophenyl)-biguanide hydrochloride (0.6-18.0 nmol), also resulted in increases in intragastric pressure. |
2(0,0,0,2) | Details |
| 15197536 | Lambert GA, Donaldson C, Hoskin KL, Boers PM, Zagami AS: Dilatation induced by in the middle meningeal artery of the anaesthetised cat. Naunyn Schmiedebergs Arch Pharmacol. 2004 Jun;369(6):591-601. Epub 2004 May 7. In chloralose-anaesthetised cats, we studied the effects of intravenous and intra-carotid injections of on the middle meningeal artery and the way these were modified by antagonists. |
0(0,0,0,0) | Details |