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Casini A, Cunningham M, Rojkind M, Lieber CS: Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis-dependent mechanism. Hepatology. 1991 Apr;13(4):758-65.
We studied the regulation of this effect by determining the expression of procollagen type I, fibronectin and transforming growth factor-beta 1 messenger RNAs in passage 1 and 2 cultures of fat-storing cells exposed to acetaldehyde for up to 24 hr.
The effect of acetaldehyde was not modified when cells were cultured in the presence of the acetaldehyde dehydrogenase inhibitor cyanamide (100 mumol/L). |
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