Protein Information

Name choline acetyltransferase
Synonyms CHAT; CHOACTase; CLAT; CMS1A; CMS1A2; ChAT; Choline O acetyltransferase; Choline acetylase…

Compound Information

Name cyanamide
CAS cyanamide

Reference List

PubMed Abstract RScore(About this table)
17045751 Jamal M, Ameno K, Ameno S, Morishita J, Wang W, Kumihashi M, Ikuo U, Miki T, Ijiri I: Changes in cholinergic function in the frontal cortex and hippocampus of rat exposed to ethanol and acetaldehyde. Neuroscience. 2007 Jan 5;144(1):232-8. Epub 2006 Oct 11.

To better understand the mechanisms of EtOH and ACe's effects on the cholinergic system in the brain, choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) expression was examined at 40 and 240 min after a dose of EtOH (1 g/kg) in the rat frontal cortex and hippocampus.
The control group was treated with 0.9% saline, and other groups received EtOH or cyanamide (CY, 50 mg/kg, a potent aldehyde dehydrogenase inhibitor) and 60 min later by EtOH intraperitoneally.
7(0,0,0,7) Details
17590992 Jamal M, Ameno K, Ikuo U, Kumihashi M, Wang W, Ijiri I: Ethanol and acetaldehyde: in vivo quantitation and effects on cholinergic function in rat brain. Novartis Found Symp. 2007;285:137-41; discussion 141-4

The results showed that acetaldehyde was present in the cyanamide (CY) + EtOH, CY + 4-methylpyrazole (4-MP) + EtOH and CY + sodium azide + EtOH groups.
Second, the effects of EtOH and acetaldehyde on choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) were investigated in the frontal cortex and hippocampus of high acetaldehyde-producing rats using RT-PCR and Western blot.
4(0,0,0,4) Details