Protein Information

Name muscles
Synonyms COX 7a M; COX VIIa M; COX7A; COX7A1; COX7A1 protein; COX7AH; COX7AM; Cytochrome c oxidase subunit 7a H…

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
7836189 Solomon IC, Motekaitis AM, Wong MK, Kaufman MP: NMDA receptors in caudal ventrolateral medulla mediate reflex airway dilation arising from the hindlimb. J Appl Physiol. 1994 Oct;77(4):1697-704.

Using chloralose-anesthetized dogs, we found that bilateral microinjections into the CVLM of either (+/-)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (25 mM, 50 nl) or (+/-)-2-amino-5-phosphonovaleric acid (50 mM, 50 nl), both of which block N-methyl-D-aspartate (NMDA) receptors, reversibly attenuated the decrease in total lung resistance that was evoked by either electrical stimulation of C-fibers in the sciatic nerve or by static contraction of both gastrocnemius muscles.
32(0,1,1,2) Details
16168409 Pilyavskii AI, Maznychenko AV, Maisky VA, Kostyukov AI, Hellstrom F, Windhorst U: Capsaicin-induced effects on c-fos expression and NADPH-diaphorase activity in the feline spinal cord. Eur J Pharmacol. 2005 Oct 3;521(1-3):70-8. Epub 2005 Sep 15.

The distribution of c-fos expression and NADPH-diaphorase reactivity in the cervical and lumbar segments after stimulation of the vanilloid receptors in the dorsal neck muscles with capsaicin was studied in cats anaesthetized with alpha-chloralose.
32(0,1,1,2) Details
7841390 Schwarz M, Block F, Pergande G: N-methyl-D-aspartate (NMDA)-mediated muscle relaxant action of flupirtine in rats. Neuroreport. 1994 Oct 3;5(15):1981-4.

The present study examined in urethane-chloralose anaesthetized rats whether N-methyl-D-aspartate (NMDA) is involved in the depressant effect of flupirtine on the monosynaptic Hoffmann (H)-reflex recorded from plantar foot muscles and on polysynaptic flexor reflexes recorded from tibialis muscle.
6(0,0,1,1) Details
8429923 Williams CA, Holtsclaw LI, Chiverton JA: Release of immunoreactive neuropeptide Y from brainstem sites in the cat during isometric contractions. Neuropeptides. 1993 Jan;24(1):53-61.

Fatiguing isometric contractions of the left hind-limb muscles in cats anesthetized with alpha-chloralose caused mean arterial pressure to increase by 82 +/- 18 mmHg above resting and post-contraction levels and heart rates to increase by 15 +/- 5 beats/min.
6(0,0,1,1) Details
8387164 Johansson H, Djupsjobacka M, Sjolander P: Influences on the gamma-muscle spindle system from muscle afferents stimulated by KCl and lactic acid. Neurosci Res. 1993 Jan;16(1):49-57.

It is known that accumulation of contraction metabolites in muscles stimulates group III and IV afferents and induces excitation of gamma-efferents to the homonymous muscle.
The experiments were made on 7 cats anesthetized with alpha-chloralose.
5(0,0,0,5) Details
7874514 Djupsjobacka M, Johansson H, Bergenheim M: Influences on the gamma-muscle-spindle system from muscle afferents stimulated by increased intramuscular concentrations of arachidonic acid. Brain Res. 1994 Nov 14;663(2):293-302.

It is also known that activity in groups III and IV muscle afferents may activate gamma-motoneurones to both homo- and heteronymous muscles.
The experiments were made on five cats anaesthetized with alpha-chloralose.
5(0,0,0,5) Details
11819039 Thunberg J, Ljubisavljevic M, Djupsjobacka M, Johansson H: Effects on the fusimotor-muscle spindle system induced by intramuscular injections of hypertonic saline. Exp Brain Res. 2002 Feb;142(3):319-26. Epub 2001 Dec 13.

This study was undertaken to test whether intramuscular injections of HS (5%) influence the activity of primary and secondary muscle spindle afferents (MSAs) from homonymous as well as heteronymous muscles.
The experiments were performed on six cats anaesthetised with alpha-chloralose.
5(0,0,0,5) Details
16223767 Haouzi P, Chenuel B: Control of arterial PCO2 by somatic afferents in sheep. J Physiol. 2005 Dec 15;569(Pt 3):975-87. Epub 2005 Oct 13.

Information from the skeletal muscles related to the local vascular response provides the central nervous system with a respiratory stimulus proportional to the rate at which gases are exchanged in the muscles, thereby coupling ventilation to the metabolic rate.
The ventilatory response to electrically induced rhythmic muscle contractions (ERCs) was studied in six urethane-chloralose-anaesthetized sheep, while arterial oxygen and carbon dioxide pressure (P (a,O (2)) and P (a,CO2)) and perfusion pressure were maintained constant at the known chemoreception sites.
1(0,0,0,1) Details
9878876 Mazario J, Roza C, Herrero JF: The NSAID dexketoprofen trometamol is as potent as mu-opioids in the depression of wind-up and spinal cord nociceptive reflexes in normal rats. Brain Res. 1999 Jan 23;816(2):512-7.

The experiments were performed in male Wistar rats anaesthetised with alpha-chloralose.
The nociceptive reflexes were recorded as single motor units in peripheral muscles, activated by mechanical and electrical stimulation.
1(0,0,0,1) Details
14523079 Lemay MA, Grill WM: Modularity of motor output evoked by intraspinal microstimulation in cats. J Neurophysiol. 2004 Jan;91(1):502-14. Epub 2003 Oct 1.

We studied the forces produced at the cat's hindpaw by microstimulation of the ipsi- and contralateral lumbar spinal cord in spinal intact alpha-chloralose anesthetized (n = 3) or decerebrate (n = 3) animals.
The fields were generally produced by coactivation of the hindlimb muscles.
1(0,0,0,1) Details
10576168 Ono T, Ishiwata Y, Kuroda T, Nakamura Y: Suppression of jaw-opening and trigemino-hypoglossal reflexes during swallowing in the cat. J Dent Res. 1999 Nov;78(11):1720-6.

Data were obtained from 8 chloralose-anesthetized cats.
Reflexes were monitored by electromyographic activities recorded from the anterior digastric, genioglossus, and styloglossus muscles and, after paralysis, by the efferent discharge in the digastric and hypoglossal nerves.
1(0,0,0,1) Details
9087637 Solomon IC, Adamson TP: Static muscular contraction elicits a pressor reflex in the chicken. Am J Physiol. 1997 Mar;272(3 Pt 2):R759-65.

Static contraction of the gastrocnemius muscle was evoked by electrically stimulating the sciatic nerve at 1.5-3.0 times motor threshold (30-40 Hz; 0.025 ms) in 13 chloralose-anesthetized cockerels.
We conclude that static muscular contraction of the gastrocnemius muscle in the chicken elicits a pressor response and that this response is due to a reflex arising from the contracting muscles.
1(0,0,0,1) Details
8023017 Wilson CR, Vanelli G, Magder S, Hussain SN: Phrenic afferent stimulation by bradykinin and the distribution of the inspiratory motor drive. Respir Physiol. 1994 Apr;96(1):1-12.

To assess whether bradykinin causes similar effects, we injected boluses of bradykinin into the phrenic artery of in situ, isolated and innervated left hemi-diaphragm preparations in 8 alpha-chloralose anesthetized, vagotomized, mechanically ventilated dogs.
Inspiratory motor drive during spontaneous breathing attempts was assessed from the integrated EMG activity of several inspiratory muscles.
1(0,0,0,1) Details
7596486 Williams CA, Gopalan R, Nichols PL, Brien PL: Fatiguing isometric contraction of hind-limb muscles results in the release of immunoreactive neurokinins from sites in the rostral medulla in the anesthetized cat. Neuropeptides. 1995 Apr;28(4):209-18.

Antibody-coated microprobes were used to determine whether immunoreactive neurokinins (irNK) were released from sites in the brainstem during fatiguing isometric contractions of the triceps surae muscles in cats anesthetized with alpha-chloralose.
7(0,0,1,2) Details
8941516 Amis TC, O'Neill N, Van der Touw T, Tully A, Brancatisano A: Supraglottic airway pressure-flow relationships during oronasal airflow partitioning in dogs. J Appl Physiol. 1996 Nov;81(5):1958-64.

We studied pressure-flow relationships in the supraglottic airway of eight prone mouth-open anesthetized (intravenous chloralose or pentobarbital sodium) crossbred dogs (weight 15-26 kg) during increasing respiratory drive (CO2 administration; n = 4) and during graded-voltage electrical stimulation (SV; n = 4) of the soft palate muscles.
6(0,0,1,1) Details
11240074 Thunberg J, Hellstrom F, Sjolander P, Bergenheim M, Wenngren B, Johansson H: Influences on the fusimotor-muscle spindle system from chemosensitive nerve endings in cervical facet joints in the cat: possible implications for whiplash induced disorders. Pain. 2001 Mar;91(1-2):15-22.

The aim of the present study was to establish if there exists reflex connections from ligamentous structures in cervical facet joints and the fusimotor system of dorsal neck muscles.
In seven cats, anaesthetized with alpha-chloralose, bradykinin (BK) of concentrations between 12 and 50 microg was injected into the facet joint between C1 and C2.
4(0,0,0,4) Details
11557619 Hayashi N, Hayes SG, Kaufman MP: Comparison of the exercise pressor reflex between forelimb and hindlimb muscles in cats. Am J Physiol Regul Integr Comp Physiol. 2001 Oct;281(4):R1127-33.

In thirteen cats anesthetized with alpha-chloralose, we compared the cardiovascular and ventilatory responses to both static contraction and tendon stretch of a hindlimb muscle group, the triceps surae, with those to contraction and stretch of a forelimb muscle group, the triceps brachii.
4(0,0,0,4) Details
8365965 Litmanovitz I, Martin RJ, Haxhiu MA, Cattarossi L, Haxhiu-Poskurica B, Carlo WA: Regulation of expiratory muscles during postnatal development in anesthetized piglets. J Appl Physiol. 1993 Jun;74(6):2655-60.

Studies were performed in anesthetized (urethan and chloralose) piglets of two age groups (< 6 days, n = 10; 14-21 days, n = 11) before and after bilateral cervical vagotomy.
4(0,0,0,4) Details
12944534 Kuo JJ, Lee RH, Johnson MD, Heckman HM, Heckman CJ: Active dendritic integration of inhibitory synaptic inputs in vivo. J Neurophysiol. 2003 Dec;90(6):3617-24. Epub 2003 Aug 27.

We measured the interaction between dendritic PICs and inhibition generated by tonic electrical stimulation of nerves to antagonist muscles during voltage clamp in motoneurons in the lumbar spinal cord of the cat.
Separate samples of cells were obtained for two different states of monoaminergic input: standard (provided by the decerebrate preparation, which has tonic activity in monoaminergic axons) and minimal (the chloralose anesthetized preparation, which lacks tonic monoaminergic input).
1(0,0,0,1) Details
8101520 Teitelbaum J, Borel CO, Magder S, Traystman RJ, Hussain SN: Effect of selective diaphragmatic paralysis on the inspiratory motor drive. J Appl Physiol. 1993 May;74(5):2261-8.

Using alpha-chloralose-anesthetized mechanically ventilated vagotomized dogs, we assessed the effects of selective diaphragmatic paralysis on the inspiratory motor drive.
The inspiratory motor drive during spontaneous breathing attempts was assessed by measuring peak integrated electromyographic (EMG) activities of the left and right diaphragms and parasternal and alae nasi muscles.
1(0,0,0,1) Details
8013577 Wood SA, Morgan DL, Gregory JE, Proske U: Fusimotor activity and the tendon jerk in the anaesthetised cat. Exp Brain Res. 1994;98(1):101-9.


This is a study of the tendon jerk reflex elicited by a brief stretch applied to the triceps surae muscle group in the chloralose-anaesthetised cat.
0(0,0,0,0) Details
8213270 Gromysz H, Karczewski WA, Kosmal A, Kukwa A: Horseradish peroxidase localization of the mylohyoid motoneurones in the rabbit. Acta Neurobiol Exp. 1993;53(2):421-4.

Experiments were performed with anaesthetized (urethan and chloralose) spontaneously breathing rabbits.
It is assumed that the N.V.mt. directing their axons to the muscles of the upper respiratory airways, simultaneously send collaterals to the central respiratory neurones participating in the regulation of the respiratory rhythm.
1(0,0,0,1) Details
9124482 Haouzi P, Beyaert C, Gille JP, Chalon B, Marchal F: Laryngeal reflex apnea is blunted during and after hindlimb muscle contraction in sheep. Am J Physiol. 1997 Feb;272(2 Pt 2):R586-92.

This study was carried out on seven chloralose-anesthetized sheep and was designed to investigate the role of muscular afferent fiber stimulation on the duration of reflex apnea triggered by laryngeal stimulation (LS).
Electrically induced contractions (EIC) of the hindlimb muscles doubled the metabolic rate and ventilation and reduced the duration of the apnea produced by LS to 7.4 +/- 1.0 s (P < 0.01).
1(0,0,0,1) Details
10450168 Poppe H, Schindler R, Sauer W, Marx D, Bartsch R, Kaverina NV, Lichoscherstow AM, Sokolov SF, Lyskovtsev VV, Seredenin SB, Borisenko SA: New aminocarboxamides with class III anti-arrhythmic activity. Arch Pharm. 1999 Jul;332(7):233-42.

The chemical synthesis, the structure-activity relationships of the new derivatives, their efficacy on the action potential duration (APD) and the effective refractory period (ERP) in vitro of isolated guinea pig papillary muscles are described and discussed in this paper.
The pro-arrhythmic effect of 14, investigated in a model of triggered activity in chloralose-anaesthetized rabbits under methoxamine infusion, is low in comparison with other class III anti-arrhythmics.
1(0,0,0,1) Details
9638595 Krutki P, Grottel K, Mrowczynski W: Lumbar collaterals of neurons of the C6 segment projecting to sacral segments of the cat spinal cord. J Physiol Paris. 1998 Feb;92(1):37-42.

Electrophysiological investigations of neurons of the C6 segment of the spinal cord were made in alpha-chloralose anesthetized animals.
The existence of collaterals to various segments of the lumbosacral enlargement indicates that the same information conveyed by long descending propriospinal neurons can reach separate motor centers controlling various muscles of the hindlimbs.
1(0,0,0,1) Details
14578483 Osaka T: Thermogenesis elicited by skin cooling in anaesthetized rats: lack of contribution of the cerebral cortex. J Physiol. 2004 Mar 1;555(Pt 2):503-13. Epub 2003 Oct 24.

Non-noxious cooling stimuli were delivered to the shaved back of urethane-chloralose-anaesthetized, artificially ventilated rats using a plastic bag containing water at 24-40 degrees C.
Cooling of the skin by 2-6 degrees C increased the rate of whole body oxygen consumption (.V (O (2)) and triggered electromyographic (EMG) activity recorded from the neck or femoral muscles.
1(0,0,0,1) Details
9949822 Lemon RN, Baker SN, Davis JA, Kirkwood PA, Maier MA, Yang HS: The importance of the cortico-motoneuronal system for control of grasp. Novartis Found Symp. 1998;218:202-15; discussion 215-8.

Intracellular recordings show that 75% of upper limb motoneurons in the chloralose-anaesthetized macaque monkey receive a monosynaptic projection from the corticospinal tract; evidence for non-monosynaptic, propriospinal excitatory influences from the corticospinal tract was conspicuously lacking in these anaesthetized preparations.
In addition to their direct effects on target muscles there may be weaker but potentially important effects that derive from the synchronous binding of assemblies of output neurons.
1(0,0,0,1) Details
7592223 Balkowiec A, Szulczyk P: Properties of postganglionic sympathetic fibers isolated from the right recurrent laryngeal nerve. J Appl Physiol. 1995 Aug;79(2):594-9.

We also discuss the possibility that class II neurons are responsible for regulating the smooth muscles of upper airways.
The pattern of response of 45 single postganglionic sympathetic axons dissected from the right recurrent laryngeal nerve was examined in chloralose-anesthetized cats.
1(0,0,0,1) Details
7840340 Lublin A, Wolfenson D, Berman A: Sex differences in blood flow distribution of normothermic and heat-stressed rabbits. Am J Physiol. 1995 Jan;268(1 Pt 2):R66-71.

Animals were anesthetized with alpha-chloralose, and BF distribution was determined by radioactive microspheres in the thermoneutral state and then again during hyperthermia after 2 h of heat exposure.
BF to the toe and ear skin and to nasal turbinates was lower in females than in males, whereas that to the diaphragm, sternum, intercostal muscles, spleen, and skeletal muscles was higher in females.
1(0,0,0,1) Details
7666146 Fagerson MH, Barmack NH: Responses to vertical vestibular stimulation of neurons in the nucleus reticularis gigantocellularis in rabbits. J Neurophysiol. 1995 Jun;73(6):2378-91.

This vestibular information may be important for controlling the intensity of the muscle activity in muscles such as neck muscles where the load on the muscle is affected by the position of the head with respect to gravity.
Chloralose-urethan anesthetized rabbits were stimulated with an exponential "step" and/or static head-tilt stimulus, as well as sinusoidal rotation about the longitudinal or interaural axes providing various combinations of roll or pitch, respectively.
1(0,0,0,1) Details
12171139 Lemon RN, Maier MA, Armand J, Kirkwood PA, Yang HW: Functional differences in corticospinal projections from macaque primary motor cortex and supplementary motor area. Adv Exp Med Biol. 2002;508:425-34.

We made a quantitative comparison of the density of macaque corticospinal projections from primary motor cortex (M1) and supplementary motor area (SMA) to spinal motor nuclei supplying hand and finger muscles.
We also compared the action of corticospinal outputs from these two areas on 84 upper limb (mostly hand) motoneurones in chloralose-anaesthetised macaques.
1(0,0,0,1) Details
1749644 Mense S, Skeppar P: Discharge behaviour of feline gamma-motoneurones following induction of an artificial myositis. Pain. 1991 Aug;46(2):201-10.

In chloralose-anaesthetized cats, artificial myositis was induced in the lateral gastrocnemius-soleus (LGS) muscle and several hours later the impulse activity was recorded from single gamma-motoaxons supplying the medial gastrocnemius (MG) muscle.
Instead, the data may offer an explanation for the weakness and--in chronic cases--the reflex atrophy of lesioned muscles.
1(0,0,0,1) Details
7478294 Johansson H, Sjolander P, Sojka P, Wenngren BI: Effects of L-DOPA on fusimotor control of triceps surae muscle spindles in the cat. Neurosci Res. 1995 Jun;22(3):307-14.

The experiments were performed on lightly alpha-chloralose anaesthetised and spinalized cats.
The effects of L-DOPA on fusimotor reflexes from ipsi- and contralateral hind limb afferents were investigated by using extensions of the intact contralateral hind limb and tonic stretches of the ipsilateral posterior biceps and semitendinosus muscles as reflex stimuli.
1(0,0,0,1) Details
1568985 Peters J, Ihle P: Coronary and systemic vascular response to inspiratory resistive breathing. J Appl Physiol. 1992 Mar;72(3):905-13.

The experiments were performed under chloralose anesthesia (to exclude any confounding emotional effects by dyspnea on cardiovascular variables) and hyperoxic conditions (to prevent chemoreflex activation by hypoxemia).
Compared with mechanical ventilation with the respiratory muscles at rest, spontaneous breathing alone and moderate and severe inspiratory resistive loading induced pronounced and significant increases in circumflex coronary blood flow (19, 32, and 62%, respectively), which were almost exclusively accounted for by significant decrements in coronary vascular resistance and were paralleled (r = 0.88, P less than 0.0001) by significant increments (18, 31, and 57%) in heart rate transmural-aortic pressure product, an indicator of LV myocardial O2 demand.
1(0,0,0,1) Details
1876427 Yezierski RP, Broton JG: Functional properties of spinomesencephalic tract (SMT) cells in the upper cervical spinal cord of the cat. Pain. 1991 May;45(2):187-96.

Response and receptive field properties were evaluated for 62 spinomesencephalic tract cells in the upper cervical spinal cord (C1-C3) of cats anesthetized with sodium pentobarbital and alpha-chloralose.
Peripheral receptive fields included muscles, joints, cornea, dura, forelimbs, hind limbs, tail, and/or testicles.
1(0,0,0,1) Details
15862794 Hu JW, Sun KQ, Vernon H, Sessle BJ: Craniofacial inputs to upper cervical dorsal horn: implications for somatosensory information processing. Brain Res. 2005 May 17;1044(1):93-106. Epub 2005 Apr 7.

A total of 74 nociceptive neurons classified as wide-dynamic-range (WDR) or nociceptive-specific (NS), as well as 72 low-threshold mechanoreceptive (LTM) neurons, was studied in urethane/chloralose-anesthetized rats.
In contrast to LTM neurons, many C1 and C2 DH nociceptive neurons received mechanosensitive convergent afferent inputs from cervical and craniofacial deep tissues (e.g., tongue muscles or temporomandibular joint), and over 50% could be activated by hypoglossal (XII) nerve electrical stimulation.
1(0,0,0,1) Details
8444737 Road JD, Osborne S, Wakai Y: Delayed poststimulus decrease of phrenic motoneuron output produced by phrenic nerve afferent stimulation. J Appl Physiol. 1993 Jan;74(1):68-72.

Long-lasting inhibitory effects on respiratory motoneuron output have been reported after stimulation of afferent nerves from limb muscles.
Six alpha-chloralose-anesthetized dogs were studied after vagotomy and bilateral carotid sinus nerve section.
1(0,0,0,1) Details
11711578 Ryan S, McNicholas WT, O'Regan RG, Nolan P: Reflex respiratory response to changes in upper airway pressure in the anaesthetized rat. J Physiol. 2001 Nov 15;537(Pt 1):251-65.


Experiments were performed in 49 chloralose-anaesthetized, tracheostomized rats.
0(0,0,0,0) Details
8810968 Raunest J, Sager M, Burgener E: Proprioceptive mechanisms in the cruciate ligaments: an electromyographic study on reflex activity in the thigh muscles. J Trauma. 1996 Sep;41(3):488-93.

Electromyographic (EMG) studies of the quadriceps and hamstrings muscles were performed in six sheep anesthetized by intravenous injection of chloralose on applying static and dynamic shear forces to isolated fascicle bundles in the anterior (ACL) and posterior (PCL) cruciate ligaments at 200 to 500 N and 50 to 200 N/sec, respectively.
10(0,0,1,5) Details
1399981 Ward ME, Deschamps A, Roussos C, Hussain SN: Effect of phrenic afferent stimulation on pattern of respiratory muscle activation. J Appl Physiol. 1992 Aug;73(2):563-70.

Ventilation and electromyogram (EMG) activities of the right hemidiaphragm, parasternal intercostal, triangularis sterni, transversus abdominis, genioglossus, and alae nasi muscles were measured before and during central stimulation of the left thoracic phrenic nerve in 10 alpha-chloralose anesthetized vagotomized dogs.
10(0,0,1,5) Details
8024003 Fregosi RF: Changes in the neural drive to abdominal expiratory muscles in hemorrhagic hypotension. Am J Physiol. 1994 Jun;266(6 Pt 2):H2423-9.

The purpose of this study was to test the hypothesis that hemorrhage-induced hypotension increases the neural drive to the abdominal expiratory muscles in chloralose-urethan-anesthetized cats that are studied under conditions of constant arterial PCO2 (PaCO2) and hyperoxia.
10(0,0,1,5) Details
7601210 Schwarz M, Schmitt T, Pergande G, Block F: N-methyl-D-aspartate and alpha 2-adrenergic mechanisms are involved in the depressant action of flupirtine on spinal reflexes in rats. Eur J Pharmacol. 1995 Apr 4;276(3):247-55.

In urethane-chloralose anesthetised rats the muscle relaxant activity of flupirtine was investigated on the monosynaptic Hoffmann reflex recorded from plantar foot muscles and on the polysynaptic flexor reflex recorded from tibialis muscle.
6(0,0,1,1) Details
15883803 Hellstrom F, Roatta S, Thunberg J, Passatore M, Djupsjobacka M: Responses of muscle spindles in feline dorsal neck muscles to electrical stimulation of the cervical sympathetic nerve. Exp Brain Res. 2005 Sep;165(3):328-42. Epub 2005 May 10.

Experiments were carried out in cats anesthetized with alpha-chloralose.
6(0,0,0,6) Details
1888993 Hill JM, Kaufman MP: Intrathecal serotonin attenuates the pressor response to static contraction. Brain Res. 1991 May 31;550(1):157-60.

We tested the hypothesis that intrathecal injection of serotonin onto the lumbosacral spinal cord of chloralose-anesthetized cats attenuates the pressor response to static contraction of the triceps surae muscles.
6(0,0,1,1) Details
7478296 Djupsjobacka M, Johansson H, Bergenheim M, Wenngren BI: Influences on the gamma-muscle spindle system from muscle afferents stimulated by increased intramuscular concentrations of bradykinin and 5-HT. Neurosci Res. 1995 Jun;22(3):325-33.

It is also known that activity in group III and IV muscle afferents may activate gamma-motoneurones to both homonymous and heteronymous muscles.
The experiments were made on six cats anaesthetised with alpha-chloralose.
4(0,0,0,4) Details
16959914 Romaniuk JR, Dick TE, Kowalski KE, Dimarco AF: Effects of pulse lung inflation on chest wall expiratory motor activity. J Appl Physiol. 2007 Jan;102(1):485-91. Epub 2006 Sep 7.


Electromyographic (EMG) activities were recorded from both thoracic and abdominal muscles.
3(0,0,0,3) Details
7759411 Amis TC, Brancatisano A, Tully A: Thyroid cartilage movements during breathing. J Appl Physiol. 1995 Feb;78(2):441-8.

We measured lateral (outward) thyroid cartilage displacement (TCD) of the larynx in six supine anesthetized (intravenous chloralose) dogs.
During tidal breathing via a tracheostomy, phasic inspiratory TCD occurred in all dogs [0.66 +/- 0.2 mm (mean +/- SE)] together with phasic inspiratory electromyographic activity in the cricothyroid (CT) and posterior cricoarytenoid (PCA) muscles.
3(0,0,0,3) Details
2048138 Takano K, Kirchner F, Mizote M: Intact inhibition of the stretch reflex during general tetanus. . Toxicon. 1991;29(2):201-9.

After the appearance of the first sign of generalized tetanus the animal was anaesthetized by a mixture of urethane and chloralose.
The stretch reflexes were elicited manually, by the contraction of the antagonistic muscles or by a stretch device.
1(0,0,0,1) Details
9679174 Maier MA, Illert M, Kirkwood PA, Nielsen J, Lemon RN: Does a C3-C4 propriospinal system transmit corticospinal excitation in the primate? An investigation in the macaque monkey. J Physiol. 1998 Aug 15;511 ( Pt 1):191-212.

Synaptic responses to electrical stimulation of the contralateral pyramidal tract were measured in intracellular recordings from 206 upper limb motoneurones in ten chloralose-anaesthetized macaque monkeys.
From previous studies in the cat, it was expected that a lesion to the dorsolateral funiculus (DLF) at C5 would interrupt the corticospinal input to the spinal segments supplying upper limb muscles, whilst leaving intact excitation transmitted via a C3-C4 propriospinal system, the descending axons of which travel in the ventral part of the funiculus.
1(0,0,0,1) Details
18351009 Businga NK, Langenberg J, Carlson L: Successful treatment of capture myopathy in three wild greater sandhill cranes (Grus canadensis tabida). J Avian Med Surg. 2007 Dec;21(4):294-8.

Two adult and 1 juvenile free-flying greater sandhill cranes (Grus canadensis tabida) were diagnosed with capture myopathy after alpha-chloralose baiting and physical capture during a banding and feeding ecologic study.
Physical therapy consisted of assisting the cranes to stand and walk 2-8 times a day, massaging leg muscles, and moving limbs manually through the range of motion.
1(0,0,0,1) Details
11849728 Hellstrom F, Thunberg J, Bergenheim M, Sjolander P, Djupsjobacka M, Johansson H: Increased intra-articular concentration of bradykinin in the temporomandibular joint changes the sensitivity of muscle spindles in dorsal neck muscles in the cat. Neurosci Res. 2002 Feb;42(2):91-9.

To this end, 26 muscle spindle afferents (MSAs) emanating from the trapezius and splenius muscles of the anaesthetised cat (alpha-chloralose, initial dosage 60 mg/kg) were recorded during injection of Bradykinin (BK) (12.5-50 microg/ml) in the ipsilateral TMJ.
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1876759 Hussain SN, Ward ME, Gatensby AG, Roussos C, Deschamps A: Respiratory muscle activation by limb muscle afferent stimulation in anesthetized dogs. Respir Physiol. 1991 May;84(2):185-98.

In 10 chloralose anaesthetized and spontaneously breathing dogs, we assessed the effect of limb muscle afferents on the peak integrated EMG activities of the genioglossus, alae nasi, costal diaphragm, parasternal intercostal, triangularis sterni, and transverse abdominis muscles.
9(0,0,1,4) Details
7520553 Williams CA, Brien PL, Nichols PL, Gopalan R: Detection of immunoreactive substance P-like substances from cat brainstem sites during fatiguing isometric contractions. Neuropeptides. 1994 May;26(5):319-27.

Isometric contractions were generated on the left hindlimb muscles from adult cats (n = 11) anesthetized with alpha-chloralose (75 mg/kg) to determine whether immunoreactive substance P (irSP) was released from either the right periaqueductal grey (PAG) or ventrolateral medulla (VLM), sites shown to be involved with the integration of the muscle pressor response.
6(0,0,1,1) Details
9106812 Pedersen J, Sjolander P, Wenngren BI, Johansson H: Increased intramuscular concentration of bradykinin increases the static fusimotor drive to muscle spindles in neck muscles of the cat. Pain. 1997 Mar;70(1):83-91.

Responses of 29 MSAs (15 SP and 14 TR) were registered in five adult cats anaesthetised with alpha-chloralose.
6(0,0,0,6) Details
8294954 Lafleur J, Zytnicki D, Horcholle-Bossavit G, Jami L: Declining inhibition in ipsi- and contralateral lumbar motoneurons during contractions of an ankle extensor muscle in the cat. J Neurophysiol. 1993 Nov;70(5):1797-804.

Motoneurons of pretibial ankle flexor and knee flexor and extensor muscles were recorded intracellularly in chloralose- or pentobarbitone-anesthetized cats during sustained submaximal contractions of either ipsi- or contralateral gastrocnemius medialis muscle (GM). 2.
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1626146 Ward ME, Vanelli G, Hashefi M, Hussain SN: Ventilatory effects of the interaction between phrenic and limb muscle afferents. Respir Physiol. 1992 Apr-May;88(1-2):63-76.

We studied the effects on ventilation and ventilatory muscle activation of stimulation of the central ends of the left phrenic and gastrocnemius nerves separately and concurrently in 10 spontaneously breathing, alpha-chloralose anaesthetized dogs.
Stimulation of either nerve resulted in increases in the activity of the right diaphragm, parasternal intercostal and alae nasi muscles comparable in magnitude to the increase in tidal volume.
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8394486 Haidet GC: Effects of age on beta-adrenergic-mediated reflex responses to induced muscular contraction in beagles. Mech Ageing Dev. 1993 May;68(1-3):89-104.

Baseline BF was reduced in three of eight muscles after AB only in the older beagles.
To further investigate whether age-related changes in beta-adrenergic responsiveness contribute to these previously reported changes in reflex CV responses associated with advanced age, hemodynamic and regional blood flow (BF) responses to static hindlimb contraction (HLC) were evaluated during alpha-chloralose anesthesia before and after beta-adrenergic blockade (AB) in younger (2-3 years) and older (8-14 years) beagles.
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8469844 Teitelbaum J, Vanelli G, Hussain SN: Thin-fiber phrenic afferents mediate the ventilatory response to diaphragmatic ischemia. Respir Physiol. 1993 Mar;91(2-3):195-206.

We assessed the role of groups III and IV phrenic afferents in the ventilatory response to diaphragmatic ischemia in mechanically ventilated, chloralose-anaesthetized dogs using the in-situ isolated and innervated left hemidiaphragm preparation.
The inspiratory motor drive to the right (Rt Edi) and left (Lt Edi) diaphragms, parasternal (Eps), and alae nasi (Ean) muscles was measured from the peak integrated EMG activities.
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7904422 Haidet GC: Alpha-adrenergic-mediated reflex responses to induced muscular contraction are changed with age in dogs. Am J Physiol. 1993 Dec;265(6 Pt 2):H1899-908.

To further investigate whether age-related changes in alpha-adrenergic-mediated responses to muscular contraction contribute to these previously reported age-related changes in CV responses associated with advanced age, hemodynamic and regional blood flow (BF) responses at baseline and during hindlimb contraction (HLC) were evaluated both before and after alpha-blockade (alpha-AB) in older (8-14 yr old) and in younger (2-3 yr old) beagles during alpha-chloralose anesthesia. alpha-AB with phentolamine resulted in significant (P < 0.05) reductions in mean arterial pressure before and during HLC, regardless of age.
Finally, BF increases to two of four contracting muscles, as well as the combined increase in blood flow to all four contracting muscles, were attenuated after alpha-AB, regardless of age.
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9833307 Schultz-Lampel D, Jiang C, Lindstrom S, Thuroff JW: Experimental results on mechanisms of action of electrical neuromodulation in chronic urinary retention. World J Urol. 1998;16(5):301-4.

In ten female cats anesthetized with alpha-chloralose the clinical situation of sacral foramen stimulation was experimentally reproduced by isolated S2 nerve stimulation after L6-S3 laminectomy.
Stimulation responses were recorded from the bladder, peripheral nerves, and striated muscles of the foot and pelvic floor.
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11078000 Hellstrom F, Thunberg J, Bergenheim M, Sjolander P, Pedersen J, Johansson H: Elevated intramuscular concentration of bradykinin in jaw muscle increases the fusimotor drive to neck muscles in the cat. J Dent Res. 2000 Oct;79(10):1815-22.

A total of 23 muscle spindle afferents from the trapezius and splenius muscles was recorded at the C3-C4 level in 7 adult cats anesthetized with alpha-chloralose.
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8175570 Fregosi RF: Influence of hypoxia and carotid sinus nerve stimulation on abdominal muscle activities in the cat. J Appl Physiol. 1994 Feb;76(2):602-9.

The measurements included inspired ventilation (VI) and the electromyogram (EMG) of the external and internal oblique and transversus abdominis muscles in 12 supine cats that were anesthetized with chloralose (50 mg/kg) and breathed spontaneously.
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1653920 Sojka P, Sjolander P, Johansson H, Djupsjobacka M: Influence from stretch-sensitive receptors in the collateral ligaments of the knee joint on the gamma-muscle-spindle systems of flexor and extensor muscles. Neurosci Res. 1991 Jun;11(1):55-62.

In lightly alpha-chloralose anaesthetized cats, activity was recorded simultaneously from 2-4 primary muscle spindle afferents from triceps surae and/or posterior biceps and semitendinosus muscles.
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1514939 Munakata Y, Tsuji M, Kasai S: The origin of short- and long-latency mylohyoid nerve responses elicited by high-intensity electrical stimulation of intradental nerve in cats. Arch Oral Biol. 1992 Aug;37(8):671-3.

A double reflex response of the mylohyoid nerve to the jaw depressor muscles after electrical stimulation of the intradental nerves was recorded in cats anaesthetized with alpha-chloralose.
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11299217 Hayes SG, Kaufman MP: Gadolinium attenuates exercise pressor reflex in cats. Am J Physiol Heart Circ Physiol. 2001 May;280(5):H2153-61.

The exercise pressor reflex, which arises from the contraction-induced stimulation of group III and IV muscle afferents, is widely believed to be evoked by metabolic stimuli signaling a mismatch between blood/oxygen demand and supply in the working muscles.
To determine this role, we examined the effect of gadolinium, which blocks mechanosensitive channels, on the exercise pressor reflex in both decerebrate and alpha-chloralose-anesthetized cats.
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10338306 Solano R, Herrero JF: Response properties of hind limb single motor units in normal rats and after carrageenan-induced inflammation. Neuroscience. 1999;90(4):1393-402.

We have therefore characterized the properties of single motor units in normal Wistar male rats and in rats with carrageenan-induced inflammation, under alpha-chloralose anaesthesia.
Units were studied from three different muscles: peroneus longus, tibialis anterior and extensor digitorum longus.
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12445238 Kontani H, Shiraoya C: Sex difference in urethral response to electrical stimulation of efferent nerves in the pudendal sensory branch of rats. Int J Urol. 2002 Oct;9(10):586-95; discussion 596.

METHODS: Wistar rats were anesthetized with urethane and alpha-chloralose.
RESULTS: Though ES of the L6-S1 trunk caused fibrillation of the muscles near the tail and steep reduction of the UP, it caused elevation and reduction of UP in male and female rats, respectively, after intravenous injection of d-tc (0.3 mg/kg).
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1884766 Rudomin P, Jimenez I, Enriquez M: Effects of stimulation of group I afferents from flexor muscles on heterosynaptic facilitation of monosynaptic reflexes produced by Ia and descending inputs: a test for presynaptic inhibition. Exp Brain Res. 1991;85(1):93-102.

In the chloralose anesthetized cat, conditioning stimulation of group I flexor afferents depresses the monosynaptic potentials generated by Ia afferents in single spinal motoneurons or in populations of motoneurons without affecting the monosynaptic potentials produced by stimulation of descending fibers in the ipsilateral ventromedial fasciculus (VMF). 2.
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10487300 Kopczynska B, Szereda-Przestaszewska M: Response of respiratory muscles to intravenous nicotine challenge in anaesthetized cats. Respir Physiol. 1999 Aug 3;116(2-3):145-57.

The effects of an intravenous nicotine challenge on the ventilation and activity of rib cage muscles were studied in 33 pentobarbitone-chloralose anaesthetized cats.
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9763639 Gladden MH, Jankowska E, Czarkowska-Bauch J: New observations on coupling between group II muscle afferents and feline gamma-motoneurones. J Physiol. 1998 Oct 15;512 ( Pt 2):507-20.

Extra- or intracellular recordings were made from seventy-six gamma-motoneurones of hindlimb muscles in chloralose anaesthetized cats to re-assess the coupling between secondary muscle spindle afferents (group II muscle afferents) and these neurones.
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12801892 Kang YM, Kenney MJ, Spratt KF, Pickar JG: Somatosympathetic reflexes from the low back in the anesthetized cat. J Neurophysiol. 2003 Oct;90(4):2548-59. Epub 2003 Jun 11.

In 27 alpha-chloralose-anesthetized cats, the L2-4 multifidus muscles were injected with the inflammatory irritant mustard oil (20%, 60 microl total) and a vertebral load (100% body weight) was applied dorsal-ventral at the L3 spinous process.
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1664760 Herrero JF, Headley PM: The effects of sham and full spinalization on the systemic potency of mu- and kappa-opioids on spinal nociceptive reflexes in rats. Br J Pharmacol. 1991 Sep;104(1):166-70.

Flexor withdrawal reflexes to noxious mechanical pinch stimuli were recorded as single motor unit activity in alpha-chloralose anaesthetized rats, by means of tungsten bipolar electrodes inserted percutaneously into hindlimb flexor muscles.
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1407679 Williams CA, Holtsclaw LI, Chiverton JA: Release of immunoreactive enkephalinergic substances in the periaqueductal grey of the cat during fatiguing isometric contractions. Neurosci Lett. 1992 May 11;139(1):19-23.

Antibody-coated microprobes were used to determine whether immunoreactive enkephalins were released in response to fatiguing isometric contractions of the hind-limb muscles in cats anesthetized with alpha-chloralose.
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12869283 Solano R, Mazario J, Orellana JM, Herrero JF: Male Wistar rats show uniform wind-up responses in carrageenan-induced inflammation but not in the normal situation. Lab Anim. 2003 Jul;37(3):207-14.

The experiments were performed in normal and carrageenan-induced inflammation in male Wistar rats anesthetized with alpha-chloralose.
In inflammation, however, C-fibre mediated wind-up became very uniform in the muscles studied, with a similar shape and saturation point.
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1644116 Fedirchuk B, Hochman S, Shefchyk SJ: An intracellular study of perineal and hindlimb afferent inputs onto sphincter motoneurons in the decerebrate cat. Exp Brain Res. 1992;89(3):511-6.

The external urethral sphincter (EUS) and external anal sphincter (EAS) are striated muscles that function to maintain urinary and fecal continence respectively.
Intracellular recordings from antidromically identified EUS and EAS motoneurons provided records of the postsynaptic potentials (PSPs) produced by electrical stimulation of peripheral afferents in decerebrate or chloralose anesthetized cats.
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10420018 Caicoya AG, Illert M, Janike R: Monosynaptic Ia pathways at the cat shoulder. . J Physiol. 1999 Aug 1;518 ( Pt 3):825-41.

The Ia synergistic groups receive Ia convergence from muscles acting at distant joints and also project to distant muscles.
In 11 chloralose-anaesthetized cats maximum Ia EPSPs evoked by electrical stimulation of ipsilateral forelimb nerves were obtained in 309 intracellularly recorded alpha-motoneurones. 2.
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12543631 Hayashi N: Exercise pressor reflex in decerebrate and anesthetized rats. Am J Physiol Heart Circ Physiol. 2003 Jun;284(6):H2026-33. Epub 2003 Jan 23.

I investigated whether muscular contraction evokes cardiorespiratory increases (exercise pressor reflex) in alpha-chloralose- and chloral hydrate-anesthetized and precollicular, midcollicular, and postcollicular decerebrated rats.
Mean arterial pressure (MAP), heart rate (HR), and minute ventilation (Ve) were recorded before and during 1-min sciatic nerve stimulation, which induced static contraction of the triceps surae muscles, and during 1-min stretch of the calcaneal tendon, which selectively stimulated mechanosensitive receptors in the muscles.
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15031132 Osaka T: Cold-induced thermogenesis mediated by GABA in the preoptic area of anesthetized rats. Am J Physiol Regul Integr Comp Physiol. 2004 Aug;287(2):R306-13. Epub 2004 Mar 18.

Bilateral microinjections of GABA (300 mM, 100 nl) or the GABA (A) receptor agonist muscimol (100 microM, 100 nl) into the preoptic area (POA) of the hypothalamus increased the rate of whole body O (2) consumption (VO (2)) and the body core (colonic) temperature of urethane-chloralose-anesthetized, artificially ventilated rats.
The GABA-induced thermogenesis was accompanied by a tachycardic response and electromyographic (EMG) activity recorded from the femoral or neck muscles.
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7899727 Wilson LB, Wall PT, Pawelczyk JA, Matsukawa K: Cardiorespiratory and phrenic nerve responses to graded muscle stretch in anesthetized cats. Respir Physiol. 1994 Nov-Dec;98(3):251-66.

Using eight alpha-chloralose anesthetized cats, the left and right triceps surae muscles were stretched individually and simultaneously at progressive increments (0.5, 1.0, 1.5, 1.75 cm).
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15732761 Maznychenko AV: [Effect of muscle pain on c-fos expression and NADPH-diaphorase activity in the spinal cord]. Fiziol Zh. 2004;50(6):62-75.

Capsaicin (Sigma, 5 mg/l ml) was unilaterally injected into dorsal neck muscles (mm. trapezius, splenius) of the cat (n = 6) anesthetized with alpha-chloralose.
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15601736 Boggs JW, Wenzel BJ, Gustafson KJ, Grill WM: Spinal micturition reflex mediated by afferents in the deep perineal nerve. J Neurophysiol. 2005 May;93(5):2688-97. Epub 2004 Dec 15.

This study investigated the changes in bladder pressure and urethral sphincter activity resulting from electrical stimulation of afferents in the deep perineal nerve (DP), which innervates the urethra and surrounding muscles, before and after acute spinal cord transection (SCT) in cats anesthetized with alpha-chloralose monitored by blood pressure and heart rate.
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7777220 Djupsjobacka M, Johansson H, Bergenheim M, Sjolander P: Influences on the gamma-muscle-spindle system from contralateral muscle afferents stimulated by KCl and lactic acid. Neurosci Res. 1995 Feb;21(4):301-9.

The aim of the present study was to investigate whether increased concentrations of lactic acid and potassium chloride (KCl) in contralateral muscles can influence the sensitivity of primary and secondary muscle spindle afferents (MSAs) from ipsilateral extensor and flexor muscles.
The experiments were performed on 7 cats anaesthetised with alpha-chloralose.
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11462081 Kang YM, Wheeler JD, Pickar JG: Stimulation of chemosensitive afferents from multifidus muscle does not sensitize multifidus muscle spindles to vertebral loads in the lumbar spine of the cat. Spine (Phila Pa 1976). 2001 Jul 15;26(14):1528-36.

METHODS: Single unit activity from muscle spindles in the L6 multifidus muscle were recorded from the cut peripheral end of the L6 dorsal root in alpha-chloralose-anesthetized cats and in decerebrate unanesthetized cats.
STUDY DESIGN: Electrophysiologic recordings from muscle spindle afferents innervating the lumbar multifidus muscle of the cat while loading the L6 vertebra at its spinous process and while exposing the segmentally adjacent lumbar multifidus muscles to algesic and inflammatory mediators.
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11049870 Daniels JW, Stebbins CL, Longhurst JC: Hemodynamic responses to static and dynamic muscle contractions at equivalent workloads. Am J Physiol Regul Integr Comp Physiol. 2000 Nov;279(5):R1849-55.

We tested the hypothesis that static contraction causes greater reflex cardiovascular responses than dynamic contraction at equivalent workloads [i.e., same tension-time index (TTI), holding either contraction time or peak tension constant] in chloralose-anesthetized cats.
When time was held constant and tension was allowed to vary, dynamic contraction of the hindlimb muscles evoked greater increases (means +/- SE) in mean arterial pressure (MAP; 50 +/- 7 vs. 30 +/- 5 mmHg), popliteal blood velocity (15 +/- 3 vs. 5 +/- 1 cm/s), popliteal venous PCO (2) (15 +/- 3 vs. 3 +/- 1 mmHg), and a greater decrease in popliteal venous pH (0.07 +/- 0.01 vs. 0.03 +/- 0.01), suggesting greater metabolic stimulation during dynamic contraction.
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10880879 Talwar A, Fahim M: Hemodynamic responses to hypoxia and hypercapnia during acute normovolemic hemodilution in anesthetized cats. Jpn J Physiol. 2000 Apr;50(2):227-34.

Cats anesthetized with a mixture of alpha-chloralose and urethane were maintained by positive pressure ventilation.
Muscles were paralysed by intramuscular vecuronium (0.1 mg/kg) to eliminate reflex respiratory movements.
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1403310 Ito H: [Reflex control of laryngeal functions in the cat: the effect of vibratory stimuli of the laryngeal mucosa on the laryngeal reflex]. Nippon Jibiinkoka Gakkai Kaiho. 1992 Aug;95(8):1164-73.

To investigate the effect of vibratory stimuli of the subglottic mucosa on the laryngeal reflex, experiments were performed on cats anesthetized with intraperitoneal injection of a mixture of urethane and chloralose.
Electromyograms (EMG) were recorded from the contralateral thyreoarytenoid (TA), posterior cricoarytenoid (PCA), lateral cricoarytenoid (LCA), and cricothyreoid (CT) muscles.
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9018488 Raimondi G, Legramante JM, Iellamo F, Frisardi G, Cassarino S, Peruzzi G: Noxious stimuli do not determine reflex cardiorespiratory effects in anesthetized rabbits. J Appl Physiol. 1996 Dec;81(6):2421-7.

In 15 anesthetized (alpha-chloralose and urethan) rabbits, low (3-Hz)- and high-frequency (100-Hz) electrical dental pulp stimulation was performed.
Because this stimulation caused dynamic and static reflex contractions of the digastric muscles leading to jaw opening jaw-opening reflex (JOR); an indirect sign of algoceptive fiber activation], experimentally induced direct dynamic and static contractions of the digastric muscle were also performed.
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8159281 Williams CA, Holtsclaw LI, Nichols LP, Brien PL, Chiverton JA: Inhibition in the release of immunoreactive beta-endorphin from the periaqueductal grey during isometric contractions of cat hind-limb muscles: the effects of clonidine. Neuropeptides. 1994 Jan;26(1):11-9.

Glass microelectrodes, coated with antibodies specific for beta-endorphin, were inserted into the right periaqueductal grey (PAG) (at PO.5-1.0 mm, LR 2.0 mm and 6.0 mm below the dorsal surface of the colliculi) of cats anesthetized with alpha-chloralose to determine whether immunoreactive beta-endorphins (ir-END) were released in response to fatiguing isometric contractions of the hind-limb muscles.
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17012352 Kim JK, Hayes SG, Kindig AE, Kaufman MP: Thin-fiber mechanoreceptors reflexly increase renal sympathetic nerve activity during static contraction. Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H866-73. Epub 2006 Sep 29.

To shed some light on this question, we recorded the renal sympathetic nerve responses to static contraction before and after injection of gadolinium into the arterial supply of the statically contracting triceps surae muscles of decerebrate unanesthetized and chloralose-anesthetized cats.
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