| Name | IL 12 (protein family or complex) |
|---|---|
| Synonyms | Cytotoxic lymphocyte maturation factor; Cytotoxic lymphocyte maturation factors; IL 12; IL12; Natural killer cell stimulatory factor; Natural killer cell stimulatory factors |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9266806 | Li L, Hamilton RF Jr, Taylor DE, Holian A: Acrolein-induced cell death in human alveolar macrophages. . Toxicol Appl Pharmacol. 1997 Aug;145(2):331-9. Acrolein caused a dose-dependent inhibition of release of IL-1beta, TNF-alpha, and IL-12. |
81(1,1,1,1) | Details |
| 18566440 | Kasahara DI, Poynter ME, Othman Z, Hemenway D, van der Vliet A: Acrolein inhalation suppresses lipopolysaccharide-induced inflammatory cytokine production but does not affect acute airways neutrophilia. J Immunol. 2008 Jul 1;181(1):736-45. However, exposure to acrolein after LPS instillation markedly diminished the LPS-induced production of several inflammatory cytokines, specifically TNF-alpha, IL-12, and the Th1 cytokine IFN-gamma, which was associated with reduction in NF-kappaB activation. |
81(1,1,1,1) | Details |
| 17950725 | Borchers MT, Wesselkamper SC, Harris NL, Deshmukh H, Beckman E, Vitucci M, Tichelaar JW, Leikauf GD: CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure. Exp Mol Pathol. 2007 Dec;83(3):301-10. Epub 2007 Sep 26. METHODS: We analyzed pulmonary inflammation and alveolar destruction in wild-type and Cd8-deficient mice chronically exposed to acrolein, a potent respiratory tract irritant. The expression of several inflammatory cytokines (IP-10, IFN-gamma, IL-12, RANTES, and MCP-1), MMP2 and MMP9 gelatinase activity, and caspase3 immunoreactivity in pulmonary epithelial cells were attenuated in the Cd8-deficient mice compared to wild-type. |
1(0,0,0,1) | Details |
| 19605955 | Bryniarski K, Szczepanik M, Ptak M, Zemelka M, Ptak W: Influence of cyclophosphamide and its metabolic products on the activity of peritoneal macrophages in mice. Pharmacol Rep. 2009 May-Jun;61(3):550-7. Our experiments show that treatment of Mf with ACR or NM stimulates the in vitro production of pro-inflammatory IL-6 and IL-12 and down-regulates anti-inflammatory IL-10 and TGF-beta cytokines. |
1(0,0,0,1) | Details |