| Name | catalase |
|---|---|
| Synonyms | CAT; Catalase; Erythrocyte derived growth promoting factor; Carnitine O acetyltransferase; Carnitine acetylase; Carnitine acetyltransferase; CAT; Catalases… |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7728738 | Subramaniam S, Subramaniam S, Shyamala Devi CS: Erythrocyte antioxidant enzyme activity in CMF treated breast cancer patients. Cancer Biochem Biophys. 1994 Oct;14(3):177-82. Acrolein and phosphoramide mustard are the metabolites of cyclophosphamide which are among the causative agents which reduce the activity of dismultase, catalase, peroxidase, glutathione reductase, glutathione-S-transferase and glucose-6-phosphate dehydrogenase in erythrocytes of CMF treated breast cancer patients. |
81(1,1,1,1) | Details |
| 19596284 | Roy J, Pallepati P, Bettaieb A, Tanel A, Averill-Bates DA: Acrolein induces a cellular stress response and triggers mitochondrial apoptosis in A549 cells. Chem Biol Interact. 2009 Oct 7;181(2):154-67. Epub 2009 Jul 9. Inhibition by the antioxidants catalase, polyethylene glycol-catalase, and MnTBAP showed that acrolein-induced reactive species were responsible for mitochondrial membrane hyperpolarisation. |
62(0,2,2,2) | Details |
| 9567773 | Arumugam N, Sivakumar V, Thanislass J, Devaraj H: Effects of acrolein on rat liver antioxidant defense system. Indian J Exp Biol. 1997 Dec;35(12):1373-4. Following 45 days of acrolein exposure, the levels of and the activity of catalase were decreased whereas the activities of superoxide dismutase and peroxidase were increased. |
6(0,0,1,1) | Details |
| 18501200 | Ansari MA, Roberts KN, Scheff SW: Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury. Free Radic Biol Med. 2008 Aug 15;45(4):443-52. Epub 2008 May 3. At various times post-TBI, animals were killed and the hippocampus was analyzed for antioxidants (GSH, peroxidase, glutathione reductase, glutathione-S-transferase, glucose-6-phosphate dehydrogenase, superoxide dismutase, and catalase) and oxidants (acrolein, protein carbonyl, and |
6(0,0,1,1) | Details |
| 18607771 | Zhu H, Jia Z, Strobl JS, Ehrich M, Misra HP, Li Y: Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous in rat aortic smooth muscle cells: cytoprotection against oxidative and electrophilic stress. Cardiovasc Toxicol. 2008 Fall;8(3):115-25. Epub 2008 Jul 8. Here we report that incubation of rat aortic smooth muscle A10 cells with (0.25-5 microM) resulted in concentration-dependent induction of a spectrum of important cellular antioxidants and phase 2 enzymes, including superoxide dismutase (SOD), catalase, the reduced form of (GSH), peroxidase, glutathione reductase (GR), glutathione S-transferase (GST), and NAD (P) H:quinone oxidoreductase 1 (NQO1). Pretreatment with (0.5, 1, and 5 microM) protected aortic smooth muscle cells from oxidative and electrophilic cytotoxicity induced by xanthine oxidase (XO)/ H2O2, SIN-1-derived and acrolein. |
3(0,0,0,3) | Details |
| 19032949 | Yoshida M, Tomitori H, Machi Y, Hagihara M, Higashi K, Goda H, Ohya T, Niitsu M, Kashiwagi K, Igarashi K: Acrolein toxicity: Comparison with reactive species. Biochem Biophys Res Commun. 2009 Jan 9;378(2):313-8. Epub 2008 Nov 24. Toxicity of H (2) O (2) was prevented by peroxidase plus N-acetyl- catalase, and reduced by polyphenol, and toxicity of () OH was prevented by peroxidase plus N-acetyl- catalase and reduced by N-acetyl- |
1(0,0,0,1) | Details |
| 8430435 | Awasthi S, Boor PJ: Semicarbazide protection from in vivo oxidant injury of vascular tissue by allylamine. Toxicol Lett. 1993 Feb;66(2):157-63. Previous studies showed that allylamine-induced chronic lesions are markedly reduced by semicarbazide, an inhibitor of semicarbazide-sensitive amine oxidase (SSAO), and that allylamine is metabolized to the acrolein, by SSAO. Aorta, epicardium, and endocardium were assayed for SSAO, peroxidase, catalase, thiol status and lipid peroxidation. |
1(0,0,0,1) | Details |
| 18367636 | Zhu H, Jia Z, Zhang L, Yamamoto M, Misra HP, Trush MA, Li Y: Antioxidants and phase 2 enzymes in macrophages: regulation by Nrf2 signaling and protection against oxidative and electrophilic stress. Exp Biol Med. 2008 Apr;233(4):463-74. As compared with wild-type cells, Nrf2 (- /-) macrophages were much more susceptible to cell injury induced by reactive / species, as well as two known macrophage toxins, acrolein and cadmium. Incubation of wild-type macrophages with 3H-1,2-dithiole-3-thione (D3T) led to significant induction of various antioxidants and phase 2 enzymes, including catalase, peroxidase (GPx), glutathione reductase, glutathione S-transferase, and NAD (P) H:quinone oxidoreductase 1. |
1(0,0,0,1) | Details |
| 8721611 | Agostinelli E, Przybytkowski E, Averill-Bates DA: and cellular response to oxidation products. Free Radic Biol Med. 1996;20(5):649-56. When catalase was present, cytotoxicity is attributed to -derived (s). did not protect cells against cytotoxicity induced by -derived (s), nor by the acrolein. |
1(0,0,0,1) | Details |
| 9022075 | Anderson MM, Hazen SL, Hsu FF, Heinecke JW: Human neutrophils employ the myeloperoxidase- peroxide- system to convert -amino acids into and acrolein. J Clin Invest. 1997 Feb 1;99(3):424-32. generation required neutrophil activation and a free -amino acid; it was inhibited by catalase and heme poisons, implicating H202 and myeloperoxidase in the cellular reaction. |
1(0,0,0,1) | Details |
| 8068243 | Averill-Bates DA, Agostinelli E, Przybytkowski E, Mondovi B: Aldehyde dehydrogenase and cytotoxicity of purified bovine serum amine oxidase and in Chinese hamster ovary cells. Biochem Cell Biol. 1994 Jan-Feb;72(1-2):36-42. It has been suggested that the dialdehyde produced during the oxidation of subsequently undergoes spontaneous beta-elimination to form acrolein. The inhibition patterns of NAD-dependent aldehyde dehydrogenase and catalase against cytotoxicity of bovine serum amine oxidase were determined in Chinese hamster ovary cells at 37 degrees C. |
4(0,0,0,4) | Details |
| 7945412 | Agostinelli E, Przybytkowski E, Mondovi B, Averill-Bates DA: Heat enhancement of cytotoxicity induced by oxidation products of in Chinese hamster ovary cells. Biochem Pharmacol. 1994 Sep 15;48(6):1181-6. Heat also increased the individual cytotoxicity of both exogenous H2O2 and the exogenous acrolein. The effect of temperature was especially marked in the presence of exogenous catalase. |
3(0,0,0,3) | Details |
| 2842890 | Ramos K, Grossman SL, Cox LR: Allylamine-induced vascular toxicity in vitro: prevention by semicarbazide-sensitive amine oxidase inhibitors. Toxicol Appl Pharmacol. 1988 Aug;95(1):61-71. Single cell suspensions of VEC or SMC formed acrolein (ACR) when incubated in the presence of AAM. The effect of catalase, a peroxide scavenger, on AAM-induced cytotoxicity was also evaluated. |
2(0,0,0,2) | Details |
| 16828947 | Bhatia K, Kaur M, Atif F, Ali M, Rehman H, Rahman S, Raisuddin S: Aqueous extract of Trigonella foenum-graecum L. ameliorates additive urotoxicity of buthionine sulfoximine and cyclophosphamide in mice. Food Chem Toxicol. 2006 Oct;44(10):1744-50. Epub 2006 Jun 3. Cyclophosphamide (CP) is a commonly used anti-cancer drug which causes toxicity by its reactive metabolites such as acrolein and phosphoramide mustard. CP-treated animals exhibited a significant decrease in the activities of glutathione S-transferase (GST), glutathione reductase (GR), peroxidase (GP) and catalase (CAT) when compared to the controls. |
1(0,0,0,1) | Details |
| 8784495 | Johnson WC, Cluff CW, Goff WL, Wyatt CR: Reactive and intermediates and products from polyamine degradation are Babesiacidal in vitro. Ann N Y Acad Sci. 1996 Jul 23;791:136-47. Polyamines are degraded into acrolein which has also been shown to be toxic to Plasmodium spp. The toxicity was partially reversed by the addition of the ROI scavenger catalase. |
1(0,0,0,1) | Details |
| 10079053 | Arumugam N, Sivakumar V, Thanislass J, Pillai KS, Devaraj SN, Devaraj H: Acute pulmonary toxicity of acrolein in rats--underlying mechanism. . Toxicol Lett. 1999 Feb 22;104(3):189-94. The activities of catalase and peroxidase were reduced whereas an increase in the activities of superoxide dismutase was observed. |
1(0,0,0,1) | Details |
| 12763045 | Kwak MK, Kensler TW, Casero RA Jr: Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein. Biochem Biophys Res Commun. 2003 Jun 6;305(3):662-70. |
0(0,0,0,0) | Details |
| 11263996 | Sharmin S, Sakata K, Kashiwagi K, Ueda S, Iwasaki S, Shirahata A, Igarashi K: Polyamine cytotoxicity in the presence of bovine serum amine oxidase. . Biochem Biophys Res Commun. 2001 Mar 23;282(1):228-35. Amine oxidase in fetal calf serum produces aminodialdehyde generating acrolein spontaneously, H (2) O (2), and from |
0(0,0,0,0) | Details |
| 2264722 | Levitz SM, DiBenedetto DJ, Diamond RD: Inhibition and killing of fungi by the polyamine oxidase-polyamine system. Antonie Van Leeuwenhoek. 1990 Aug;58(2):107-14. Two putative end products of the system, peroxide and acrolein, both killed C. neoformans at concentrations attainable with the whole system. |
0(0,0,0,0) | Details |