Protein Information

Name somatostatin
Synonyms Growth hormone release inhibiting factor; SMST; SST; Somatostatin; Somatostatin precursor; Somatostatins; Somatostatin precursors

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
15475512 Hansen L, Lampert S, Mineo H, Holst JJ: Neural regulation of glucagon-like peptide-1 secretion in pigs. Am J Physiol Endocrinol Metab. 2004 Nov;287(5):E939-47.


In chloralose-anesthetized pigs, however, electrical stimulation of the vagal trunks at the level of the diaphragm had no effect on GLP-1 or GLP-2 and weak effects on glucose-dependent insulinotropic peptide and somatostatin secretion, although this elicited a marked atropine-resistant release of the neuropeptide vasoactive intestinal polypeptide to the portal circulation.
0(0,0,0,0) Details
8780231 Bereiter DA, Benetti AP, Bereiter DF, Hathaway CB: Central trigeminal effects of somatostatin and etorphine on adrenal and autonomic function in the cat. Am J Physiol. 1996 Mar;270(3 Pt 2):R636-44.

The influence of somatostatin and the potent mu-opiate receptor agonist etorphine on adrenal and autonomic responses mediated by trigeminal neurons was examined in chloralose-anesthetized cats.
35(0,1,1,5) Details
7540111 Wilson LB, Wall PT, Matsukawa K: Attenuation of the reflex responses to muscle contraction by the coadministration of antagonists to substance P and somatostatin into the dorsal horn. Cardiovasc Res. 1995 Mar;29(3):379-84.

METHODS: Using alpha chloralose anaesthetised cats (n = 8), static contraction and stretch of the triceps surae muscle were performed before and after microinjecting (1 microliter) 250 ng of the substance P antagonist, D-Pro2-D-Phe7-D-Trp9-substance P, and the somatostatin antagonist, cyclo (7-amino-heptanoyl-phenylalanyl-D-tryptophyl-lysyl-threonyl-[ benzyl]).
34(0,1,1,4) Details
7907323 Haxhiu MA, Deal EC, Van Lunteren E, Cherniack NS: Central effects of somatostatin and atrial natriuretic peptide on tracheal tone. J Appl Physiol. 1993 Dec;75(6):2353-9.

The effects of somatostatin and atrial natriuretic peptide applied topically to the ventral surface of the medulla (VMS) on tracheal tone and phrenic nerve activity (Phr) were studied in chloralose-anesthetized and paralyzed cats artificially ventilated with 7% CO2 in O2.
11(0,0,1,6) Details
1370923 Wilson LB, Wall PT, Matsukawa K, Mitchell JH: Effect of spinal microinjections of an antagonist to substance P or somatostatin on the exercise pressor reflex. Circ Res. 1992 Feb;70(2):213-22.

Anesthesia was induced by administering an anesthetic gas mixture and was subsequently maintained with alpha-chloralose.
2(0,0,0,2) Details
7844313 Nakabayashi H, Niijima A, Nishizawa M, Nakabayashi IO, Takeda R: A unique receptor-mediated mechanism in vagal chemoreception of somatostatin in the hepatoportal area. J Auton Nerv Syst. 1994 Dec 1;50(1):45-50.

Intraportal SS injection at a physiological dose (3.05 pmol) significantly facilitated the afferent firing discharge rate of the hepatic vagus in rats anesthetized with urethane and chloralose.
2(0,0,0,2) Details
8949386 Verwaerde P, Bordet R, Portolan G, Tran MA, Marques MA, Montastruc JL, Senard JM: [Effects of octreotide on experimental orthostatic neurogenic hypotension] . Arch Mal Coeur Vaiss. 1996 Aug;89(8):1097-1101.

The synthetic somatostatin analogue, octreotide, has recently been proposed for the treatment of both postprandial and orthostatic hypotension (OH) in humans with autonomic failure related to multiple system atrophy (MSA) or diabetes mellitus.
We investigated in a model of neurogenic orthostatic hypotension, obtained by chronic sinoaortic denervation (SAD) in chloralose-anaesthetized dogs, the effects of octreotide (0.1 mg/kg, subcutaneous route) during a double-blind cross-over study vs placebo.
1(0,0,0,1) Details