Protein Information

Name orexin
Synonyms HCRT; PPOX; Hcrt; Hypocretin; Hypocretin neuropeptide; OX; Orexin; Orexin precursor…

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
12531738 de Oliveira CV, Rosas-Arellano MP, Solano-Flores LP, Ciriello J: Cardiovascular effects of hypocretin-1 in nucleus of the solitary tract. Am J Physiol Heart Circ Physiol. 2003 Apr;284(4):H1369-77. Epub 2002 Dec 12.

In the second series, in alpha-chloralose or urethane-anesthetized rats, microinjection of Hcrt-1 (0.5-5 pmol) into the caudal NTS elicited a dose-dependent decrease in MAP and HR.
13(0,0,1,8) Details
12834893 de Oliveira CV, Rosas-Arellano MP, Solano-Flores LP, Babic T, Li Z, Ciriello J: Estrogen alters the bradycardia response to hypocretin-1 in the nucleus tractus solitarius of the ovariectomized female. Brain Res. 2003 Jul 18;978(1-2):14-23.

Microinjections of hcrt-1 (0.5-10 pmol) into the caudal lateral and medial subnuclei of the NTS complex of the alpha-chloralose of the urethane-anaesthetized E-treated OVX rat elicited a dose-related decrease in heart rate (HR).
3(0,0,0,3) Details
19962375 Yamuy J, Fung SJ, Xi M, Chase MH: State-dependent control of lumbar motoneurons by the hypocretinergic system. Exp Neurol. 2010 Feb;221(2):335-45. Epub 2009 Dec 3.

Neurons in the lateral hypothalamus (LH) that synthesize hypocretins (Hcrt-1 and Hcrt-2) are active during wakefulness and excite lumbar motoneurons.
Accordingly, cat lumbar motoneurons were intracellularly recorded, under alpha-chloralose anesthesia, prior to (control) and during the carbachol-induced REM sleep-like atonia (REMc).
3(0,0,0,3) Details
16125857 Cerri M, Morrison SF: Activation of lateral hypothalamic neurons stimulates brown adipose tissue thermogenesis. Neuroscience. 2005;135(2):627-38.

The lateral hypothalamic area, containing orexin neurons, is involved in several aspects of autonomic regulation, including thermoregulation and energy expenditure.
To determine if activation of lateral hypothalamic area neurons influences sympathetically-regulated thermogenesis in brown adipose tissue, we microinjected bicuculline (120 pmol, 60 nl, unilateral) into the lateral hypothalamic area in urethane/chloralose-anesthetized, artificially-ventilated rats.
1(0,0,0,1) Details
12573979 Ciriello J, de Oliveira CV: Cardiac effects of hypocretin-1 in nucleus ambiguus. Am J Physiol Regul Integr Comp Physiol. 2003 Jun;284(6):R1611-20. Epub 2003 Feb 6.

In the second series, the Amb region that contained hcrt-1 and hcrtR-1-ir was explored for sites that elicited changes in HR and MAP in urethane and alpha-chloralose-anesthetized rats.
1(0,0,0,1) Details
20045031 Kobashi M, Xuan SY, Fujita M, Mitoh Y, Matsuo R: Central ghrelin inhibits reflex swallowing elicited by activation of the superior laryngeal nerve in the rat. Regul Pept. 2010 Feb 25;160(1-3):19-25. Epub 2010 Jan 1.

Fourth ventricular administration of orexin-A (3 nmol) also inhibited reflex swallowing elicited by SLN stimulation.
The effect of ghrelin on rhythmic reflex swallowing was examined in urethane-chloralose anesthetized rats.
1(0,0,0,1) Details