Protein Information

Name NK1
Synonyms BY55; CD160; CD160 antigen; CD160 antigen precursor; CD160 molecule; NK1; NK28; Natural killer cell receptor BY55…

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
7582497 Chizh BA, Cumberbatch MJ, Birch PJ, Headley PM: Endogenous modulation of excitatory amino acid responsiveness by tachykinin NK1 and NK2 receptors in the rat spinal cord. Br J Pharmacol. 1995 Jul;115(6):1013-9.

The effects of selective tachykinin (neurokinin, NK) NK1 and NK2 receptor antagonists have been examined on spinal neurones in alpha-chloralose anaesthetized, spinalized rats.
85(1,1,1,5) Details
9453348 Diz DI, Westwood B, Bosch SM, Ganten D, Ferrario C: NK1 receptor antagonist blocks angiotensin II responses in renin transgenic rat medulla oblongata. Hypertension. 1998 Jan;31(1 Pt 2):473-9.

Injections of Ang II (250 fmol in 30 nL) into the nTS of chloralose-urethane anesthetized TG rats produced a significant increase in pressure of 7+/-2 mm Hg before a 13+/-3 mm Hg fall in pressure.
3(0,0,0,3) Details
18554294 Bongianni F, Mutolo D, Cinelli E, Pantaleo T: Neurokinin receptor modulation of respiratory activity in the rabbit. Eur J Neurosci. 2008 Jun;27(12):3233-43. Epub 2008 Jun 1.

The respiratory role of neurokinin (NK) receptors was investigated in alpha-chloralose-urethane-anaesthetized, vagotomized, paralysed and artificially ventilated rabbits by using bilateral microinjections (30-50 nL) of NK receptor agonists and antagonists.
We used as agonists (0.1, 0.5 and 5 mM) substance P (SP), the NK1 receptor agonists [Sar (9), Met (O2)(11)]-SP and GR 73632, the NK2 receptor agonist NKA, the NK3 receptor agonist senktide, and as antagonists (5 mM) the NK1 receptor antagonist CP-99,994 and the NK2 receptor antagonist MEN 10376.
2(0,0,0,2) Details
7582496 Cumberbatch MJ, Chizh BA, Headley PM: Modulation of excitatory amino acid responses by tachykinins and selective tachykinin receptor agonists in the rat spinal cord. Br J Pharmacol. 1995 Jul;115(6):1005-12.

The agonists were applied by microiontophoresis in in vivo experiments in alpha-chloralose-anaesthetized, spinalized rats. 2.
The NK1-selective agonist, GR 73632, enhanced responses to all three EAAs similarly, whilst the NK2-selective agonist, GR64349, reduced responses to AMPA and kainate without affecting those to NMDA, and the NK3 selective agonist, senktide, enhanced responses to AMPA and kainate. 3.
1(0,0,0,1) Details