Protein Information

Name IL 1beta
Synonyms Catabolin; IL 1; IL 1 beta; IL 1B; IL1 beta; IL1B; IL1F2; Interleukin 1…

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
11476285 Saindon CS, Blecha F, Musch TI, Morgan DA, Fels RJ, Kenney MJ: Effect of cervical vagotomy on sympathetic nerve responses to peripheral interleukin-1beta. Auton Neurosci. 2001 Mar 23;87(2-3):243-8.

In the present study we determined renal, interscapular brown adipose tissue (IBAT), splenic, and lumbar SND responses before and for 60 min after the intravenous administration of interleukin-1beta (IL-1beta, 100 ng) in chloralose-anesthetized, sham-vagotomized and cervical-vagotomized (bilateral) rats.
11(0,0,1,6) Details
12531724 Lu N, Wang Y, Blecha F, Fels RJ, Hoch HP, Kenney MJ: Central interleukin-1beta antibody increases renal and splenic sympathetic nerve discharge. Am J Physiol Heart Circ Physiol. 2003 May;284(5):H1536-41. Epub 2003 Jan 16.

We tested the hypothesis that intracerebroventricular (lateral ventricle) administration of interleukin-1beta (IL-1beta) antibody increases the level of sympathetic nerve discharge (SND) in alpha-chloralose-anesthetized rats.
11(0,0,1,6) Details
11709410 Kenney MJ, Blecha F, Morgan DA, Fels RJ: Interleukin-1 beta alters brown adipose tissue but not renal sympathetic nerve responses to hypothermia. Am J Physiol Heart Circ Physiol. 2001 Dec;281(6):H2441-5.

Therefore, this study examined the effects of IL-1 beta (290 ng/kg iv) and mild hypothermia on renal and interscapular brown adipose tissue (IBAT) SND regulation in chloralose-anesthetized rats.
10(0,0,1,5) Details
7922597 Ichijo T, Katafuchi T, Hori T: Central interleukin-1 beta enhances splenic sympathetic nerve activity in rats. Brain Res Bull. 1994;34(6):547-53.

An intrathird cerebroventricular (I3V) infusion of recombinant human IL-1 beta (rhIL-1 beta) (1-5 ng/rat) elicited a dose-dependent increase in the electrical activity of the splenic sympathetic nerve in urethane and alpha-chloralose anesthetized rats.
10(0,0,1,5) Details
12124194 Kenney MJ, Blecha F, Wang Y, McMurphy R, Fels RJ: Sympathoexcitation to intravenous interleukin-1beta is dependent on forebrain neural circuits. Am J Physiol Heart Circ Physiol. 2002 Aug;283(2):H501-5.

We investigated the contributions of forebrain, brain stem, and spinal neural circuits to interleukin (IL)-1beta-induced sympathetic nerve discharge (SND) responses in alpha-chloralose-anesthetized rats.
9(0,0,1,4) Details
12070215 Kenney MJ, Blecha F, Fels RJ, Morgan DA: Altered frequency responses of sympathetic nerve discharge bursts after IL-1beta and mild hypothermia. J Appl Physiol. 2002 Jul;93(1):280-8.

Autospectral and coherence analyses were used to determine the effect of IL-1beta and mild hypothermia (60 min after IL-1beta, colonic temperature from 38 degrees C to 36 degrees C) on the relationships between renal-interscapular brown adipose tissue (IBAT) and splenic-lumbar sympathetic nerve discharges in chloralose-anesthetized rats.
7(0,0,1,2) Details
9124475 Ota K, Katafuchi T, Takaki A, Hori T: AV3V neurons that send axons to hypothalamic nuclei respond to the systemic injection of IL-1beta. Am J Physiol. 1997 Feb;272(2 Pt 2):R532-40.

The single neuron activity in the anteroventral region of the third ventricle (AV3V) was extracellularly recorded in urethan and alpha-chloralose anesthetized rats.
5(0,0,0,5) Details
15908469 Ganta CK, Lu N, Helwig BG, Blecha F, Ganta RR, Zheng L, Ross CR, Musch TI, Fels RJ, Kenney MJ: Central angiotensin II-enhanced splenic cytokine gene expression is mediated by the sympathetic nervous system. Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1683-91. Epub 2005 May 20.

Experiments were completed in sinoaortic nerve-lesioned, urethane-chloralose-anesthetized, splenic nerve-intact (splenic-intact) and splenic nerve-lesioned (splenic-denervated) Sprague-Dawley rats.
Splenic mRNA expression of IL-1beta, IL-6, IL-2, and IL-16 genes was increased in ANG II-treated splenic-intact rats compared with aCSF-treated splenic-intact rats.
2(0,0,0,2) Details