| Name | metallothionein (protein family or complex) |
|---|---|
| Synonyms | Metallothionein; Metallothioneins |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18649050 | Domitrovic R, Jakovac H, Grebic D, Milin C, Radosevic-Stasic B: Dose- and time-dependent effects of on liver metallothioneins and metals in carbon tetrachloride-induced hepatotoxicity in mice. Biol Trace Elem Res. 2008 Winter;126(1-3):176-85. Epub 2008 Jul 24. |
7(0,0,1,2) | Details |
| 17409699 | Min KS: [Physiological significance of metallothionein in oxidative stress] . Yakugaku Zasshi. 2007 Apr;127(4):695-702. Prooxidative agents such as paraquat and carbon tetrachloride induce MT synthesis mediated by some responsive elements. |
2(0,0,0,2) | Details |
| 15359896 | Satoh M: [Toxicological significance of metallothionein on environmental harmful factors: verification and suggestions from a metallothionein-I/II null mouse model study]. Nippon Eiseigaku Zasshi. 2004 Jul;59(3):317-25. MT-I/II null mice were found to be much more sensitive than wild-type mice to the toxicity caused by free radical-inducing factors, which include paraquat, X-ray, ultraviolet B, carbon tetrachloride, cisplatin, doxorubicin, cerulein and streptozotocin. |
2(0,0,0,2) | Details |
| 15564144 | Jiang Y, Kang YJ: Metallothionein gene therapy for chemical-induced liver fibrosis in mice. Mol Ther. 2004 Dec;10(6):1130-9. Wild-type (WT) mice treated with carbon tetrachloride in corn oil twice a week at 1 ml/kg for 4 weeks developed a reversible liver fibrosis upon removal of the chemical, correlating with a high level of hepatic MT; but those treated for 8 weeks developed an irreversible liver fibrosis along with low levels of hepatic MT. |
2(0,0,0,2) | Details |
| 18706400 | Liu J, Wu Q, Lu YF, Pi J: New insights into generalized hepatoprotective effects of oleanolic acid: key roles of metallothionein and Nrf2 induction. Biochem Pharmacol. 2008 Oct 1;76(7):922-8. Epub 2008 Jul 23. Oleanolic acid (OA) is a natural triperpenoid that protects against a variety of hepatotoxicants such as carbon tetrachloride, cadmium, and bromobenzene. |
2(0,0,0,2) | Details |
| 16730224 | Yan Y, Wanshun L, Baoqin H, Bing L, Chenwei F: Protective effects of oligosaccharide and its derivatives against carbon tetrachloride-induced liver damage in mice. Hepatol Res. 2006 Jul;35(3):178-84. Epub 2006 May 26. Pretreatment with COS, GlcNH (2), and (1.5g/kg body weight, i.g.) for 12 consecutive days prior to CCl (4) challenge significantly induced metallothionein (MT) expression. |
1(0,0,0,1) | Details |
| 19747501 | Domitrovic R, Jakovac H, Tomac J, Sain I: Liver fibrosis in mice induced by carbon tetrachloride and its reversion by Toxicol Appl Pharmacol. 2009 Dec 15;241(3):311-21. Epub 2009 Sep 8. treatment has increased hepatic matrix metalloproteinase-9 levels and metallothionein (MT) I/II expression, eliminated fibrinous deposits and restored architecture of the liver in a dose-dependent manner. |
1(0,0,0,1) | Details |
| 15963578 | Krasnov A, Koskinen H, Rexroad C, Afanasyev S, Molsa H, Oikari A: Transcriptome responses to carbon tetrachloride and pyrene in the kidney and liver of juvenile rainbow trout (Oncorhynchus mykiss). Aquat Toxicol. 2005 Aug 15;74(1):70-81. Universal reactions to chemical toxicity were observed in metallothionein, HSP90 and mitochondrial proteins of oxidative phosphorylation, which were induced in both tissues. |
1(0,0,0,1) | Details |
| 15908265 | Koh HS, Matsui A, Mimura S, Inao M, Saitoh E, Ohno A, Nagoshi S, Yoshimoto T, Mochida S, Fujiwara K: Increased cytoprotective function in the liver of transgenic mice expressing osteopontin in hepatocytes. Hepatol Res. 2005 May;32(1):46-51. Liver necrosis in the centrilobular areas developed after carbon tetrachloride treatment, but its histological extent and plasma ALT activities were significantly smaller in the transgenic mice aged 8 weeks than in the wild-type C57BL/6 control mice. We conclude that cytoprotective function of the liver is increased through up-regulated expressions of metallothionein and GST, and thereby susceptibility of hepatocytes to the stress may be less possible, if any, in the development of spontaneous liver necrosis in transgenic mice expressing osteopontin in hepatocytes. |
1(0,0,0,1) | Details |