| Name | GABA receptor (protein family or complex) |
|---|---|
| Synonyms | GABA receptor; GABA receptors; GABA(A) receptor; GABA(A) receptors; Gamma aminobutyric acid receptor; Gamma aminobutyric acid receptors |
| Name | endrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2474166 | Wafford KA, Lummis SC, Sattelle DB: Block of an insect central nervous system GABA receptor by cyclodiene and cyclohexane insecticides. Proc R Soc Lond B Biol Sci. 1989 Jun 22;237(1286):53-61. The results demonstrate that endrin and lindane block functional insect neuronal GABA receptors. |
119(1,2,3,4) | Details |
| 1685414 | Bloomquist JR, Grubs RE, Soderlund DM, Knipple DC: Prolonged exposure to activates -gated channels in the presence of channel-blocking convulsants. Comp Biochem Physiol C. 1991;99(3):397-402. In electrophysiological assays of GABA receptors expressed in Xenopus oocytes following injection with rat brain mRNA, endrin (20 microM) effectively blocked the transient currents elicited by brief exposure of oocytes to (200 microM). |
31(0,1,1,1) | Details |
| 3009836 | Abalis IM, Eldefrawi ME, Eldefrawi AT: Effects of insecticides on -induced influx into rat brain microsacs. J Toxicol Environ Health. 1986;18(1):13-23. The actions of different insecticides known to affect binding of ligands to (GABA) receptors were studied on the function of GABAA receptors in rat brain as assayed by -induced 36Cl- influx into membrane microsacs. The -induced 36Cl- flux was inhibited by several cyclodienes and gamma-hexachlorocyclohexane (gamma-BHC) with the following order of decreasing potency: endosulfan I greater than endrin greater than endosulfan II greater than dieldrin greater than heptachlor epoxide greater than gamma-BHC greater than heptachlor. |
1(0,0,0,1) | Details |
| 3000377 | Bloomquist JR, Soderlund DM: insecticides inhibit -dependent uptake by mouse brain vesicles. Biochem Biophys Res Commun. 1985 Nov 27;133(1):37-43. The insecticides endrin, dieldrin, aldrin, lindane (gamma-1,2,3,4,5,6-hexachlorocyclohexane) and deltamethrin inhibited -dependent 36Cl- uptake by mouse brain vesicles. These results demonstrate the disruption of gamma-aminobutyric acid receptor- ionophore function in mammalian brain by insecticides and provide evidence that this complex is the principal site of cyclodiene action. |
1(0,0,0,1) | Details |
| 1722072 | Narahashi T: Transmitter-activated ion channels as the target of chemical agents. Adv Exp Med Biol. 1991;287:61-73. Lindane and the cyclodienes dieldrin, endrin, heptachlor-epoxide, and isobenzan suppressed the -activated current. It seems that general anesthetics have a specific affinity for the GABA receptor-channel complex. |
2(0,0,0,2) | Details |
| 2850922 | Seifert J: Ontogenesis and properties of the convulsant recognition site (s) of the (GABA) receptor complex in chicken embryo. Eur J Pharmacol. 1988 Jul 14;151(3):443-8. The pharmacological properties of the embryonic recognition site (s) do not undergo significant changes during hatching based on the affinity of embryonic and chick brain membranes for [3H] TBOB; the rate of association and dissociation for TBOB; non-competitive inhibition of [3H] TBOB binding and modulation of 1R, alpha S-cis-cypermethrin interaction with the recognition site (s) by and inhibition of radioligand binding by endrin, picrotoxinin and TBPS. |
1(0,0,0,1) | Details |
| 2409983 | Abalis IM, Eldefrawi ME, Eldefrawi AT: Binding of GABA receptor channel drugs to a putative voltage-dependent chloride channel in Torpedo electric organ. Biochem Pharmacol. 1985 Jul 15;34(14):2579-82. |
1(0,0,0,1) | Details |
| 2458634 | Matsumoto K, Eldefrawi ME, Eldefrawi AT: Action of polychlorocycloalkane insecticides on binding of [35S] t-butylbicyclophosphorothionate to Torpedo electric organ membranes and stereospecificity of the binding site. Toxicol Appl Pharmacol. 1988 Sep 15;95(2):220-9. Endrin was more potent than dieldrin, but endosulfan I and II had similar effects. |
0(0,0,0,0) | Details |