| Name | CYP1A2 |
|---|---|
| Synonyms | CP12; CYP1A2; CYPIA 2; CYPIA2; Cytochrome P450 1A2; Dioxin inducible P3 450; P(3)450; P3 450… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15619608 | Matsunaga NK, Isawa M, Kizu J, Miyazaki N, Takanaka A, Nakashima E: Application of the PKCYP test to predict clearance mediated by CYP1A2 in a rat acute liver injury model. Drug Metab Pharmacokinet. 2003;18(5):296-302. This method was applied to estimate the amount of CYP2C11 in rats treated with carbon tetrachloride (CCl (4)-treated rats). |
5(0,0,0,5) | Details |
| 15988118 | Kose N, Yamamoto K, Sai Y, Isawa M, Suwa T, Nakashima E: Prediction of clearance in CCl4-treated rats using in vivo CYP1A2 and CYP3A2 contents assessed with the PKCYP test. Drug Metab Pharmacokinet. 2005 Jun;20(3):168-76. |
2(0,0,0,2) | Details |
| 19177741 | Ibrahim ZS, Ishizuka M, Soliman M, ElBohi K, Sobhy W, Muzandu K, Elkattawy AM, Sakamoto KQ, Fujita S: Protection by Nigella sativa against carbon tetrachloride-induced downregulation of hepatic cytochrome P450 isozymes in rats. Jpn J Vet Res. 2008 Nov;56(3):119-28. Intraperitoneal injection of rats with CCl4 drastically decreased CYP2E1, CYP2B, CYP3A2, CYP2C11, and CYP1A2 mRNA and protein expressions. |
2(0,0,0,2) | Details |
| 14706259 | Yokogawa K, Watanabe M, Takeshita H, Nomura M, Mano Y, Miyamoto K: Serum aminotransferase activity as a predictor of clearance of drugs metabolized by CYP isoforms in rats with acute hepatic failure induced by carbon tetrachloride. Int J Pharm. 2004 Jan 28;269(2):479-89. Good correlations were observed between mRNA expression and enzyme activity of CYP2C11, CYP2E1, CYP3A2 and CYP1A2 in livers of rats given various doses of CCl (4). |
2(0,0,0,2) | Details |
| 16162422 | Qin LQ, Wang PY, Wang Y, Kaneko T, Hoshi K, Sato A: Voglibose potentiates the hepatotoxicity of carbon tetrachloride and by inducing CYP2E1 in rats. Hepatol Res. 2005 Sep;33(1):50-6. Epub 2005 Sep 12. Hepatic cytochrome P450 2E1 (CYP2E1) concentration was increased at doses of 5.0 and 10.0mg/100g of voglibose and its activity increased in the three voglibose dosage groups, while hepatic cytochrome P450 3A (CYP3A) and cytochrome P450 1A2 (CYP1A2) were only slightly changed at any dose. |
1(0,0,0,1) | Details |