| Name | gamma glutamyl transferase |
|---|---|
| Synonyms | CD224; CD224 antigen; D22S672; D22S732; GGT; GGT 1; GGT1; GGT1 protein… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15573529 | Venukumar MR, Latha MS: Effect of Coscinium fenestratum on hepatotoxicity in rats. Indian J Exp Biol. 2004 Aug;42(8):792-7. Anti-hepatotoxic activity of extract of Coscinium fenestratum stem (MEC) was investigated against carbon tetrachloride-induced hepatopathy in rats. Anti-hepatotoxic effect was studied by assaying the activities of serum marker enzymes like aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamyl transpeptidase, lactate dehydrogenase etc. and glucose (6) phosphate dehydrogenase in liver. |
1(0,0,0,1) | Details |
| 17897074 | Fernandez-Martinez E, Bobadilla RA, Morales-Rios MS, Muriel P, Perez-Alvarez VM: derivatives: structure-activity relationship as hepatoprotective agents. Med Chem. 2007 Sep;3(5):475-9. The activities of gamma-glutamyl transpeptidase, alkaline phosphatase and alanine aminotransferase were measured in serum. |
1(0,0,0,1) | Details |
| 16011737 | Srinivasan M, Rukkumani R, Ram Sudheer A, Menon VP: a natural protector against carbon tetrachloride-induced toxicity. Fundam Clin Pharmacol. 2005 Aug;19(4):491-6. The activities of liver markers transaminase, transaminase, alkaline phosphatase, gamma-glutamyl transferase), lipid peroxidative index (thiobarbituric acid-reactive substances, hydroperoxides, protein carbonyl content), the antioxidant status (superoxide dismutase, catalase, peroxidase and were used as biomarkers to monitor the protective role of FA. |
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| 19446540 | Singh BN, Singh BR, Sarma BK, Singh HB: Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark. Chem Biol Interact. 2009 Sep 14;181(1):20-8. Epub 2009 May 14. Chemopreventive potential of Acacia nilotica bark extract (ANBE) against single intraperitoneal injection of N-nitrosodiethylamine (NDEA, 200mg/kg) followed by weekly subcutaneous injections of carbon tetrachloride (CCl (4), 3 ml/kg) for 6 weeks induced hepatocellular carcinoma (HCC) in rats was studied. The levels of liver injury and liver cancer markers such as transaminase (ALT), transaminase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (gamma-GT), total level (TBL), alpha-feto protein (AFP) and carcinoembryonic antigen (CEA) were substantially increased following NDEA treatment. |
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| 17828713 | Reyes-Gordillo K, Muriel P, Castaneda-Hernandez G, Favari L: Pharmacokinetics of diclofenac in rats intoxicated with CCL4, and in the regenerating liver. Biopharm Drug Dispos. 2007 Nov;28(8):415-22. One day after CCl (4) administration, indicators of necrosis (alanine aminotransferase), cholestasis (gamma-glutamyl transpeptidase) and regeneration (alpha-fetoprotein) were significantly increased; these effects were reversed after 3 days. |
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| 20096342 | Khan RA, Khan MR, Sahreen S: Evaluation of Launaea procumbens use in renal disorders: a rat model. J Ethnopharmacol. 2010 Mar 24;128(2):452-61. Epub 2010 Jan 21. INTRODUCTION: Carbon tetrachloride exerts its toxicity in rat kidneys through oxidative stress. RESULTS: CCl (4) exposure led to a significant oxidative stress in kidneys which was remarkably attenuated with co-administration of various fractions and rutin thereby increased the level of CAT, POD, SOD, GSH, GSR, GST, GSH-Px, quinone reductase, while reduced the xanthine oxidase, gamma-GT, TBARS, H (2) O (2), tissue proteins and DNA fragmentation%. |
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| 16117609 | Kim NY, Lee MK, Park MJ, Kim SJ, Park HJ, Choi JW, Kim SH, Cho SY, Lee JS: Momordin Ic and oleanolic acid from Kochiae Fructus reduce carbon tetrachloride-induced hepatotoxicity in rats. J Med Food. 2005 Summer;8(2):177-83. The momordin Ic and oleanolic acid pretreatments resulted in significantly lower serum transaminase, lactic dehydrogenase, and gamma-glutamyltransferase levels in the CCl4-treated rats. |
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| 19581077 | Adesanoye OA, Farombi EO: Hepatoprotective effects of Vernonia amygdalina (astereaceae) in rats treated with carbon tetrachloride. Exp Toxicol Pathol. 2010 Mar;62(2):197-206. Epub 2009 Jul 5. Oral administration of CCl (4) at a dose of 1.2g/kg body weight 3 times a week for 3 weeks significantly induced marked hepatic injury as revealed by increased activity of the serum enzymes ALT, AST, SALP and gamma-GT. |
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| 17383825 | Reyes-Gordillo K, Segovia J, Shibayama M, Vergara P, Moreno MG, Muriel P: protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress. Biochim Biophys Acta. 2007 Jun;1770(6):989-96. Epub 2007 Feb 22. an anti-inflammatory and antioxidant compound, was evaluated for its ability to suppress acute carbon tetrachloride-induced liver damage. Indicators of necrosis (alanine aminotransferase) and cholestasis (gamma-glutamyl transpeptidase and bilirubins) resulted in significant increases after CCl4 intoxication, but these effects were prevented by treatment. |
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| 18697572 | Kuriakose GC, Kurup GM: Antioxidant activity of Aulosira fertilisima on CCl4 induced hepatotoxicity in rats. Indian J Exp Biol. 2008 Jan;46(1):52-9. Carbon tetrachloride (CCl4) is used as a model for liver injury. Liver damage is detected by the measurement of the activities of serum enzymes like aspartate aminotransferase, alanine aminotransferase, gamma glutamyl transpeptidase and alkaline phosphatase which were released in to the blood from damaged cells. |
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| 15991578 | Pradeep K, Mohan CV, Anand KG, Karthikeyan S: Effect of pretreatment of Cassia fistula Linn. leaf extract against subacute CCl4 induced hepatotoxicity in rats. Indian J Exp Biol. 2005 Jun;43(6):526-30. CCl4 alone treatment (0.lml of liquid paraffin/100g body weight, ip) for 7 days followed by 0.l ml of CCl4 (in liquid parafiin/100g body weight, ip) from day 8 till day 14, caused a 16 fold increase in lipid peroxidation and a 50% reduction in catalase and glutathione reductase in liver tissue of rats accompanied by an increase in the activities of transaminases. alkaline phosphatase, lactate dehydrogenase and gamma - glutamyl transpeptidase in serum as compared to liquid paraffin treated control. |
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| 17541932 | Rivera H, Shibayama M, Tsutsumi V, Perez-Alvarez V, Muriel P: and trimethylated protect from acute liver damage induced by CCl4 in the rat. J Appl Toxicol. 2008 Mar;28(2):147-55. Lipid peroxidation and the activity of gamma-glutamyl transpeptidase were increased significantly after CCl4. |
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| 19067753 | Bhadauria M, Nirala SK, Shrivastava S, Sharma A, Johri S, Chandan BK, Singh B, Saxena AK, Shukla S: Emodin reverses CCl induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural changes: The in vivo evidence. Hepatol Res. 2009 Mar;39(3):290-300. Epub 2008 Dec 2. Aim: The curative effect of emodin (1,3,8-trihydroxy-6-methyl anthraquinone), an active compound of the plant species Ventilago maderaspatana Gaertn, was evaluated against carbon tetrachloride (CCl (4)) induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural alterations in rats. Results: The CCl (4) induced-toxic effects were observed with sharp elevation in the release of serum transaminases, alkaline phosphatase, lactate dehydrogenase and gamma-glutamyl transpeptidase. |
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| 18705752 | Reyes-Gordillo K, Segovia J, Shibayama M, Tsutsumi V, Vergara P, Moreno MG, Muriel P: prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress. Fundam Clin Pharmacol. 2008 Aug;22(4):417-27. Alanine aminotransferase, gamma-glutamyl transpeptidase, liver histopathology, reduced and and TGF-beta (mRNA and protein) levels were assessed. |
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| 16610055 | Ji G, Wang L, Zhang SH, Liu JW, Zheng PY, Liu T: Effect of Chinese medicine Qinggan Huoxuefang on inducing HSC apoptosis in alcoholic liver fibrosis rats. World J Gastroenterol. 2006 Apr 7;12(13):2047-52. METHODS: Wistar rats were divided into three groups at random: normal control group (12),micro-amount carbon tetrachloride group (CCl (4))(12) and model group A (60). Blood samples were used for evaluation of transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyltransferase (gamma-GT). |
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| 19220677 | Luo L, Zhou A: Antifibrotic activity of anisodamine in vivo is associated with changed intrahepatic levels of matrix metalloproteinase-2 and its inhibitor tissue inhibitors of metalloproteinases-2 and transforming growth factor beta1 in rats with carbon tetrachloride-induced liver injury. J Gastroenterol Hepatol. 2009 Jun;24(6):1070-6. Epub 2009 Feb 12. RESULTS: The serum levels of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase and of liver fibrosis rats improved significantly by treatment with anisodamine. |
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| 15934369 | Saratikov AS, Chuchalin VS, Rat'kin AV, Rat'kin EV, Fedoreev SA, Bulgakov VP: [Hepatoprotector properties of polyphenolic complexes from wood and cell culture of Maackia amurensis]. Eksp Klin Farmakol. 2005 Mar-Apr;68(2):51-4. Polyphenolic complexes (PPCs) extracted from core wood and cell culture of Maackia amurensis decrease the acute toxicity of tetrachloromethane, suppress the necrosis of hepatocytes and the cellular infiltration in liver parenchyma, prevent the development of fatty and protein dystrophy in the liver, normalize the activity of aminotransferases and gamma-glutamyltransferase in the blood, restore the protein and lipid content, and stimulate the conjugation of |
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| 17265550 | Liu J, Cho SN, Song KH, Kim DH, Kim MC, Cho SW: The effect of oculo-acupuncture on acute hepatic injury induced by carbon tetrachloride in dogs. Am J Chin Med. 2007;35(1):53-61. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma glutamyl transpeptidase (GGT) activities were measured in both control and experimental groups. |
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| 19702266 | Hsu JD, Kao SH, Tu CC, Li YJ, Wang CJ: Solanum nigrum L. extract inhibits 2-acetylaminofluorene-induced hepatocarcinogenesis through overexpression of glutathione S-transferase and antioxidant enzymes. J Agric Food Chem. 2009 Sep 23;57(18):8628-34. Our previous study has found that SN water extract (SNWE) alleviated carbon tetrachloride-induced liver damage in rats. The serum biomarkers for hepatic injury, transaminase, glutamate pyruvate transaminase, and gamma-glutamyl transferase, and for hepatocarcinogenesis, alpha-fetoprotein, were determined. |
1(0,0,0,1) | Details |
| 15588927 | Espandiari P, Robertson LW, Srinivasan C, Glauert HP: Comparison of different initiation protocols in the resistant hepatocyte model. Toxicology. 2005 Jan 31;206(3):373-81. All initiated animals were treated at the same age (11 weeks) with the following selection agents: three daily doses of 2-acetylaminofluorene (AAF) (30 mg/kg), followed by a single dose of carbon tetrachloride (2 ml/kg), followed by three additional daily treatments of AAF (30 mg/kg). |
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| 16426832 | Zhang S, Ji G, Liu J: Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin. J Nutr Biochem. 2006 Jul;17(7):485-91. Epub 2005 Oct 10. In the present study, we investigated the effects of puerarin on liver fibrosis in Wistar rats induced by plus carbon tetrachloride administration. |
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| 15700767 | Ogeturk M, Kus I, Kavakli A, Zararsiz I, Ilhan N, Sarsilmaz M: Effects of on carbon tetrachloride-induced changes in rat serum. J Physiol Biochem. 2004 Sep;60(3):205-10. Serum urea, total protein, albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total and conjugated alkaline phosphatase (ALP), gamma-glutamyl transferase (gamma-GT), total iron, and levels were determined. |
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| 19294768 | Al-Rejaie SS, Aleisa AM, Al-Yahya AA, Bakheet SA, Alsheikh A, Fatani AG, Al-Shabanah OA, Sayed-Ahmed MM: Progression of diethylnitrosamine-induced hepatic carcinogenesis in -depleted rats. World J Gastroenterol. 2009 Mar 21;15(11):1373-80. RESULTS: Administration of DENA resulted in a significant increase in transaminase (ALT), gamma-glutamyl transferase (G-GT), alkaline phosphatase (ALP), total thiobarbituric acid reactive substances (TBARS) and total / (NOx) and a significant decrease in (GSH), peroxidase (GSHPx), catalase (CAT) and total content in liver tissues. Rats in group 4 (DENA group) were injected with a single dose of DENA (200 mg/kg, i.p.) and 2 wk later received a single dose of carbon tetrachloride (2 mL/kg) by gavage as 1:1 dilution in corn oil. |
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| 18476390 | Anilakumar KR, Krishna KR, Chandramohan G, Khanum F, Bawa AS: Bees wax polyphenols as suppressor of CC1--induced oxidative stress in rats. Indian J Physiol Pharmacol. 2007 Oct-Dec;51(4):361-7. As the polyphenols are thought to protect cell constituents against oxidative damage through scavenging of free radicals, the present work was undertaken to evaluate the effects of polyphenols extracted from bees wax on the oxidative stress induced by carbon tetrachloride (CCl4) in rats. The results showed a significant decrease in hepatic antioxidant enzyme activities viz. catalase, glucose-6-phosphate dehydrogenase (G-6-PDH), peroxidase (GSH-Px), glutathione reductase, superoxide dismutase (SOD) and a significant increase in glutathione S-transferase (GST) and gamma-glutamyl transpeptidase (GGT) by CCl4, probably due to the peroxidative effects. |
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| 16213120 | Rao GM, Rao CV, Pushpangadan P, Shirwaikar A: Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J Ethnopharmacol. 2006 Feb 20;103(3):484-90. Epub 2005 Oct 5. The substantially elevated serum enzymatic activities of serum glutamic oxaloacetic transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP) and gamma-glutamyltransferase (gamma-GT) due to carbon tetrachloride treatment were dose dependently restored towards normalization. |
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| 20138953 | Lee BJ, Senevirathne M, Kim JS, Kim YM, Lee MS, Jeong MH, Kang YM, Kim JI, Nam BH, Ahn CB, Je JY: Protective effect of fermented sea tangle against and carbon tetrachloride-induced hepatic damage in Sprague-Dawley rats. Food Chem Toxicol. 2010 Apr;48(4):1123-8. Epub 2010 Feb 6. Hepatotoxicity was evaluated by measuring the serum levels of glutamic transaminase (GPT), gamma glutamyl transpeptidase (gamma-GT) and malondialdehyde (MDA) as well as the tissue levels of antioxidant enzyme such as superoxide dismutase (SOD), catalase (CAT) and peroxidase (GPx). |
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| 16696916 | Wang L, Ji G, Zheng PY, Long AH: [Establishment of a rat model of alcoholic liver fibrosis induced by complex factors]. Zhong Xi Yi Jie He Xue Bao. 2006 May;4(3):281-4. The serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (gamma-GT) in these three groups were all examined at the 12th week of the induction process. |
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| 16050911 | Yonezawa LA, Kitamura SS, Mirandola RM, Antonelli AC, Ortolani EL: Preventive treatment with alleviates the poisoning effects of carbon tetrachloride in cattle. J Vet Med A Physiol Pathol Clin Med. 2005 Aug;52(6):292-7. Food intake was recorded and blood samples collected daily for 8 days after the CCl4 drenching to compare the activity of aspartate aminotransferase (AST), gamma-glutamyltransferase (gamma-GT) and the levels of erythrocyte (GSH) and serum malonyldialdehyde (MDA). |
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| 16609998 | Cheung PY, Zhang Q, Zhang YO, Bai GR, Lin MC, Chan B, Fong CC, Shi L, Shi YF, Chun J, Kung HF, Yang M: Effect of WeiJia on carbon tetrachloride induced chronic liver injury. World J Gastroenterol. 2006 Mar 28;12(12):1912-7. Degree of fibrosis were measured and serological markers for liver fibrosis and function including (HA), type IV collagen (CIV), gamma-glutamyl transferase (gamma-GT), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. |
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| 14976334 | Espandiari P, Glauert HP, Lehmler HJ, Lee EY, Srinivasan C, Robertson LW: Initiating activity of 4-chlorobiphenyl metabolites in the resistant hepatocyte model. Toxicol Sci. 2004 May;79(1):41-6. Epub 2004 Feb 19. All animals were treated with selection agents as follows: three daily p.o. doses of 2-acetylaminofluorene (2-AAF, 30 mg/kg), followed by a single p.o. dose of carbon tetrachloride (2 ml/kg) and three additional daily treatments of 2-AAF. Livers were evaluated for changes in morphology, and the number and volume of gamma-glutamyl transpeptidase-positive foci were measured. |
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| 18811677 | Galicia-Moreno M, Rodriguez-Rivera A, Reyes-Gordillo K, Segovia J, Shibayama M, Tsutsumi V, Vergara P, Moreno MG, Fernandez-Martinez E, Perez-Alvarez VM, Muriel P: Trolox down-regulates transforming growth factor-beta and prevents experimental cirrhosis. Basic Clin Pharmacol Toxicol. 2008 Nov;103(5):476-81. Epub 2008 Sep 22. Alkaline phosphatase, gamma-glutamyl transpeptidase and alanine aminotransferase increased in the group receiving CCl4; trolox completely or partially prevented these alterations. |
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| 16176146 | Choi J, Park JK, Lee KT, Park KK, Kim WB, Lee JH, Jung HJ, Park HJ: In vivo antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4-dicaffeoylquinic acid. J Med Food. 2005 Fall;8(3):348-52. Pretreatment with DCQA (5 and 10 mg/kg, p.o.) significantly reduced serum aminotransferases and sorbitol dehydrogenase, gamma-glutamyltransferase, alkaline phosphatase, and lactate dehydrogenase activities during CCl4- or GalN-induced hepatotoxicity, suggesting that DCQA is a major principle for the antihepatotoxic activity of L. fischeri var. spiciformis. |
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| 17410408 | Bhadauria M, Nirala SK, Shukla S: Propolis protects CYP 2E1 enzymatic activity and oxidative stress induced by carbon tetrachloride. Mol Cell Biochem. 2007 Aug;302(1-2):215-24. Epub 2007 Apr 5. Intraperitoneal injection of CCl (4) (1.5 ml/kg) induced hepatotoxicity after 24 h of its administration that was associated with elevated malonyldialdehyde (index of lipid peroxidation), lactate dehydrogenase and gamma-glutamyl transpeptidase release (index of a cytotoxic effect). |
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| 19496777 | Singh D, Singh R, Singh P, Gupta RS: Effects of Embelin on Lipid Peroxidation and Free Radical Scavenging Activity against Liver Damage in Rats. Basic Clin Pharmacol Toxicol. 2009 May 26. Carbon tetrachloride (CCl (4)) treatment to rats has been more susceptible to peroxidative damage through production of reactive metabolites, namely trichloromethyl-free radicals ( and/or ) as measured by thiobarbituric acid reactive species. The activities of marker enzymes - transaminases (AST, ALT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), lactate dehydrogenase (LDH) - along with the total and total protein levels were altered significantly (P |
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| 18572298 | Bhadauria M, Nirala SK, Shukla S: Multiple treatment of propolis extract ameliorates carbon tetrachloride induced liver injury in rats. Food Chem Toxicol. 2008 Aug;46(8):2703-12. Epub 2008 Apr 27. Multiple treatment of propolis significantly prevented the release of transaminases, alkaline phosphatase, lactate dehydrogenase, gamma-glutamyl transpeptidase, urea and in serum; improved the activity of hepatic microsomal drug metabolizing enzymes, i.e., hydroxylase and amidopyrine-N-demethylase; significantly inhibited lipid peroxidation and markedly enhanced in liver and kidney as well as brought altered carbohydrate contents (blood sugar and tissue protein contents (serum, microsomal and tissue protein) and lipid contents (serum and tissue triglycerides, serum cholesterol, total and esterified in tissue) towards control. |
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| 18007553 | Alvarez GC, Madrid-Marina V, Jimenez-Mendez R, Buitimea AL, Roman MB, Cortez-Gomez R, Esparza JR, Rodriguez-Fragoso L: Combined therapy with danazol, pegilated interferon, and ribavirin improves thrombocytopenia and liver injury in rats with fibrosis. Ann Hepatol. 2007 Oct-Dec;6(4):233-41. PEG-IFN + ribavirin reduced the total concentration by 27%, amino transferase (ALT) activity by 75% and gamma-glutamyl transpeptidase (gamma-GTP) activity by 74% (P < 0.05). |
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