| Name | superoxide dismutase |
|---|---|
| Synonyms | IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19327381 | Khan MR, Ahmed D: Protective effects of Digera muricata (L.) Mart. on testis against oxidative stress of carbon tetrachloride in rat. In Vivo. 2009 Sep-Oct;23(5):747-54. It also markedly increases the level of TBARS and nitrites along with corresponding decrease in and various antioxidant enzymes in testis, i.e., catalase, peroxidase, superoxide dismutase and peroxidase. |
2(0,0,0,2) | Details |
| 15670617 | Chidambara Murthy KN, Vanitha A, Rajesha J, Mahadeva Swamy M, Sowmya PR, Ravishankar GA: In vivo antioxidant activity of carotenoids from Dunaliella salina--a green microalga. World J Gastroenterol. 2005 May 21;11(19):2984-9. Treatment of CCl4 at dose of 2.0 g/kg b.w. decreased the activities of various antioxidant enzymes like catalase, superoxide dismutase (SOD) and peroxidase by 45.9%, 56% and 54% respectively compared to control group and lipid peroxidation value increased nearly 2 folds. |
2(0,0,0,2) | Details |
| 19041730 | Cuciureanu M, Caruntu ID, Paduraru O, Stoica B, Jerca L, Crauciuc E, Nechifor M: The protective effect of montelukast on carbon tetrachloride induced hepatopathy in rat. Prostaglandins Other Lipid Mediat. 2009 Apr;88(3-4):82-8. Epub 2008 Nov 11. We also determined superoxide dismutase (SOD), MDA, CAT and GSH in liver homogenate. |
1(0,0,0,1) | Details |
| 15968718 | Gao H, Zhou YW: Anti-lipid peroxidation and protection of liver mitochondria against injuries by picroside II. Cell Biol Toxicol. 2009 Oct;25(5):499-512. Epub 2008 Sep 7. METHODS: Three animal models of liver damage induced by carbon tetrachloride (CCl (4): 0.1 mL/10 g, ip), D-galactosamine (D-GalN: 500 mg/kg, ip) and (AP: 0.15 g/kg, ip) were respectively treated with various concentrations of picroside II (5, 10, 20 mg/kg, ig). Then we chose the continuously monitoring method (recommended by International Clinical Chemistry League) to analyze serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) values, Marland method to detect the activity of manganese-superoxide dismutase (SOD) in liver mitochondria, TBA colorimetry to determine the content of malonicdialdehyde (MDA) in liver tissue, DTNB method to evaluate the activity of glutathioneperoxidase (GSH-Px) and Lowry method to detect protein level in liver tissue. |
1(0,0,0,1) | Details |
| 15276869 | Campo GM, Avenoso A, Campo S, D'Ascola A, Ferlazzo AM, Calatroni A: The antioxidant and antifibrogenic effects of the glycosaminoglycans and -4-sulphate in a subchronic rat model of carbon tetrachloride-induced liver fibrogenesis. Phytother Res. 2004 Jan;18(1):30-5. At the end of the 6-week treatment period (24 h after the last dose of GAGs), the following parameters were evaluated: (1) serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, as index of hepatic cell disruption; (2) hepatic conjugated dienes (CD), as index of lipid peroxidation; (3) hepatic TIMPs activity and expression; (4) hepatic superoxide dismutase (SOD) and peroxidase (GPx) activity, as index of endogenous defences; (5) hepatic as index of collagen deposition. |
1(0,0,0,1) | Details |
| 14992325 | Tasaduq SA, Singh K, Sethi S, Sharma SC, Bedi KL, Singh J, Jaggi BS, Johri RK: Hepatocurative and antioxidant profile of HP-1, a polyherbal phytomedicine. Hum Exp Toxicol. 2003 Dec;22(12):639-45. HP-1 a herbal formulation comprising of Phyllanthus niruri and extracts of Terminalia belerica, Terminalia chebula, Phyllanthus emblica and Tinospora cordifolia has been evaluated for hepatoprotective activity against carbon tetrachloride (CCl4) induced toxicity. HP-1 attenuated the serum toxicity as manifested in elevated levels of transaminases transaminase (GOT), and GPT) The antioxidative enzymes in liver (catalase and superoxide dismutase (SOD)) were restored to normal values after the oral administration of HP-1. |
1(0,0,0,1) | Details |
| 15320500 | Satturwar PM, Fulzele SV, Joshi SB, Dorle AK: Hepatoprotective activity of Haridradi ghrita on carbon tetrachloride-induced liver damage in rats. J Ethnopharmacol. 2008 Mar 28;116(3):539-46. Epub 2008 Jan 20. Haridradi ghrita, a ghee based polyherbal formulation, (50, 100, 200 and 300 mg/kg) significantly lowered marker enzymes (SGPT, SGOT, ALP) and in serum and liver peroxide, superoxide dismutase and catalase in liver homogenate following CCl4 (0.7 ml/kg, ip) toxicity. |
1(0,0,0,1) | Details |
| 19242656 | Liu J, Tan H, Sun Y, Zhou S, Cao J, Wang F: The preventive effects of -superoxide dismutase on carbon tetrachloride-induced acute liver failure and hepatic fibrosis in mice. Mol Cell Biochem. 2009 Jul;327(1-2):219-28. Epub 2009 Feb 26. In this study, the effects of -superoxide dismutase conjugate -SOD) on carbon tetrachloride (CCl4)-induced acute liver failure and hepatic fibrosis were evaluated. |
87(1,1,2,2) | Details |
| 16393475 | Lee SJ, Oh PS, Ko JH, Lim K, Lim KT: Protective effect of glycoprotein isolated from Ulmus davidiana Nakai on carbon tetrachloride-induced mouse liver injury. 521. We evaluated lipid peroxidation in / oxidase (G/GO)-induced BNL CL.2 cells and measured thiobarbituric acid reactive substances (TBARS), lactate dehydrogenase (LDH), (NO), antioxidant enzyme (superoxide dismutase (SOD), catalase (CAT) and peroxidase (GPx)), activity of cytotoxic-related signals (hepatic cytochrome c, nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1)) and levels of plasma lipids (triglyceride (TG) and total (TC)) in carbon tetrachloride (CCl (4,) 1.0 mL kg (-1))-induced A/J mouse. |
6(0,0,1,1) | Details |
| 15036469 | Bhandarkar MR, Khan A: Antihepatotoxic effect of Nymphaea stellata willd., against carbon tetrachloride-induced hepatic damage in albino rats. J Med Food. 2008 Jun;11(2):323-30. The oral administration of varying dosage of extract of Nymphaea stellata willd., flower to rats for 10 days afforded the good hepatoprotection against carbon tetrachloride-induced elevation in serum marker enzymes, serum liver lipid peroxidation and reduction in liver liver peroxidase, superoxide dismutase and catalase activity. |
81(1,1,1,1) | Details |
| 19449806 | Murugan V, Mukherjee K, Maiti K, Mukherjee PK: Enhanced oral bioavailability and antioxidant profile of by phospholipids. J Agric Food Chem. 2009 Jun 10;57(11):4559-65. The complex significantly protected the liver by restoring the activity of superoxide dismutase, catalase and liver and thiobarbituric acid reactive substances with respect to the carbon tetrachloride treated group (P < 0.05 and < 0.01). |
31(0,1,1,1) | Details |
| 17112692 | Maiti K, Mukherjee K, Gantait A, Saha BP, Mukherjee PK: -phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats. Liver Int. 2007 Apr;27(3):393-9. -phospholipid complex significantly protected the liver by restoring the enzyme levels of liver system and that of superoxide dismutase, catalase and thiobarbituric acid reactive substances with respect to carbon tetrachloride treated group (P < 0.05 and <0.01). |
31(0,1,1,1) | Details |
| 18586068 | Smyth R, Turton JA, Clarke CJ, York MJ, Dare TO, Lane CS, Munday MR: Identification of superoxide dismutase as a potential urinary marker of carbon tetrachloride-induced hepatic toxicity. Food Chem Toxicol. 2008 Sep;46(9):2972-83. Epub 2008 Jun 11. |
6(0,0,1,1) | Details |
| 16909447 | Nkosi CZ, Opoku AR, Terblanche SE: Antioxidative effects of pumpkin seed (Cucurbita pepo) protein isolate in CCl4-induced liver injury in low-protein fed rats. J Med Food. 2008 Mar;11(1):127-32. The effects of pumpkin seed (Cucurbita pepo) protein isolate on the plasma activity levels of catalase (CA), superoxide dismutase (SOD), peroxidase (GSHpx) and total antioxidant capacity (TAC) as well as glucose-6-phosphatase (G6Pase) in liver homogenates and lipid peroxidation (LPO-malondialdehyde-MDA) levels in liver homogenates and liver microsomal fractions against carbon tetrachloride (CCl (4))-induced acute liver injury in low-protein fed Sprague-Dawley rats (Rattus norvegicus) were investigated. |
6(0,0,1,1) | Details |
| 17140450 | Chen H, Yan X, Zhu P, Lin J: Antioxidant activity and hepatoprotective potential of agaro-oligosaccharides in vitro and in vivo. J Med Food. 2008 Jun;11(2):224-9. Results from intracellular test indicated that agaro-oligosaccharides could significantly scavenge the level of oxidants in the hepatocytes, more beneficially, also associated with the improvement of cell viability In vivo studies of the antioxidant effects on tissue peroxidative damage induced by carbon tetrachloride in rat model indicated that agaro-oligosaccharides could elevate the activity of superoxide dismutase (SOD), peroxidase (GSH-Px) and decrease the level of malondialdehyde (MDA), oxaloacetate transaminase (AST), glutamic pyruvic transaminase (ALT) significantly. |
6(0,0,1,1) | Details |
| 17963319 | Chang HY, Peng WH, Sheu MJ, Huang GJ, Tseng MC, Lai MT, Ho YL, Chang YS: Hepatoprotective and Antioxidant Effects of Extract from Phellinus merrillii on carbon tetrachloride-induced liver damage. J Anim Physiol Anim Nutr. 2007 Aug;91(7-8):333-40. Carbon tetrachloride induces up-regulation of antioxidant enzymes, including superoxide dismutase (SOD) (86.6%), catalase (58.8%) and peroxidase (GPx)(64.7%) in the liver. |
6(0,0,1,1) | Details |
| 17877538 | Smyth R, Munday MR, York MJ, Clarke CJ, Dare T, Turton JA: Comprehensive characterization of serum clinical chemistry parameters and the identification of urinary superoxide dismutase in a carbon tetrachloride-induced model of hepatic fibrosis in the female Hanover Wistar rat. Food Chem Toxicol. 2008 Oct;46(10):3311-7. Epub 2008 Aug 12. |
6(0,0,1,1) | Details |
| 16239089 | Rai S, Wahile A, Mukherjee K, Saha BP, Mukherjee PK: Antioxidant activity of Nelumbo nucifera (sacred lotus) seeds. Zhong Xi Yi Jie He Xue Bao. 2005 Nov;3(6):470-2. Administration of HANN to Wistar rats at 100 and 200 mg/kg body weight for 4 days prior to carbon tetrachloride (CCl (4)) treatment caused a significant dose dependent increase (p < 0.05 to p < 0.001) in the level of superoxide dismutase (SOD) and catalase and a significant decrease (p < 0.05 to p < 0.001) in the level of thiobarbituric acid reactive substances (TBARS), when compared to CCl (4) treated control in both liver and kidney. |
6(0,0,1,1) | Details |
| 19765104 | Smyth R, Munday MR, York MJ, Clarke CJ, Dare T, Turton JA: Dose response and time course studies on superoxide dismutase as a urinary biomarker of carbon tetrachloride-induced hepatic injury in the Hanover Wistar rat. Int J Exp Pathol. 2009 Oct;90(5):500-11. |
6(0,0,1,1) | Details |
| 18022343 | Lee SJ, Lim KT: Glycoprotein of Zanthoxylum piperitum DC has a hepatoprotective effect via anti-oxidative character in vivo and in vitro. Indian J Exp Biol. 2003 Jan;41(1):85-7. In addition, administration of ZPDC glycoprotein (20mg/kg) lowers the levels of lactate dehydrogenase, transaminase, and thiobarbituric acid reactive substances, whereas increases that of accompanying the normalizing effects on the activity of hepatic anti-oxidant enzymes (superoxide dismutase, catalase, and peroxidase) in mouse model of carbon tetrachloride-stimulated acute liver injury. |
6(0,0,1,1) | Details |
| 19568713 | Cao HX, Sun H, Jiang XG, Lu HT, Zhang GM, Wang XJ, Sun WJ, Wu ZM, Wang P, Liu L, Zhou J: Comparative study on the protective effects of Yinchenhao Decoction against liver injury induced by alpha-naphthylisothiocyanate and carbon tetrachloride. Chem Biol Interact. 2008 Nov 25;176(2-3):108-20. Epub 2008 Aug 22. METHODS: The liver injury in the model rat was induced by alpha-naphthylisothiocyanate (ANIT) and carbon tetrachloride (CCl (4) ) respectively, and the effects of Yinchenhao Decoction (, YCHD), a proved effective Chinese medical formula for treating the dampness-heat jaundice syndrome in clinic, on the two liver injury models were evaluated by analyzing the serum level of alanine aminotransferase (ALT), asparate aminotransferase (AST), alkaline phosphatase (ALP), malondialchehyche (MDA), total (T-BIL), superoxide dismutase (SOD), peroxidase (GSH-PX) as well as the ratio of liver weight to body weight. |
6(0,0,1,1) | Details |
| 16719498 | Rajesha J, Murthy KN, Kumar MK, Madhusudhan B, Ravishankar GA: Antioxidant potentials of flaxseed by in vivo model. J Agric Food Chem. 2006 May 31;54(11):3794-9. Activity was assessed by measuring hepatic marker enzymes like catalase, superoxide dismutase (SOD), and peroxidase and comparing with those from the normal group and from a group receiving toxin without flaxseed. |
3(0,0,0,3) | Details |
| 19779110 | Peng HY, Chu YC, Chen SJ, Chou ST: Hepatoprotection of chlorella against carbon tetrachloride-induced oxidative damage in rats. Int J Biol Sci. 2009 Aug 11;5(6):549-57. The reduced levels of superoxide dismutase, and catalase in the CCl (4)-treated rats were significantly increased by treatment with GPE. |
1(0,0,0,1) | Details |
| 16466176 | Wang LC, Zhao LS, Tang H: [Experimental study of liver fibrosis reversal effect of warming-yang compound formula ganzhifu]. Phytother Res. 2009 Feb;23(2):251-6. The serum liver function and hepatic fibrosis indexes, liver tissue contents of (Hyp), malondialdehyde (MDA) and superoxide dismutase (SOD) activity were measured at the end of the experiment. |
1(0,0,0,1) | Details |
| 19345057 | Peng W, Jiang X, Haiqin L, Zhang C, Zhu J, Zhang J, Zang Y, Qin J: Protective effects of transgene expressed human PON3 against CCl4-induced subacute liver injury in mice. Biomed Pharmacother. 2009 Sep;63(8):592-8. Epub 2008 Sep 17. Moreover, transgene expression of hPON3 attenuated oxidative stress by increasing hepatic content, superoxide dismutase (SOD) activity, total antioxidant capability (T-AOC), and reducing malondialdehyde (MDA) level. |
1(0,0,0,1) | Details |
| 18598176 | Kim HY, Kim JH, Lee SA, Chang HE, Park MH, Hwang SJ, Lee JY, Mok C, Hong SG: Saengshik, a formulated health food, prevents liver damage in CCl4-induced mice and increases antioxidant activity in elderly women. J Physiol Biochem. 2009 Sep;65(3):225-33. The activity of the antioxidant enzyme superoxide dismutase was increased, and the level of glutamate pyruvate transaminase was decreased. |
1(0,0,0,1) | Details |
| 19345075 | Yan F, Zhang QY, Jiao L, Han T, Zhang H, Qin LP, Khalid R: Synergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in rats. Phytomedicine. 2009 Sep;16(9):805-13. Epub 2009 Apr 2. In the liver, significantly elevated levels (p <0.001) of malondialdehyde (MDA), lowered levels of (GSH) (p <0.05) and catalase (CAT) (p <0.001), superoxide dismutase (SOD) (p <0.01) were observed following CCl (4) administration. 'LFS+ASP' treatment of rats at doses of 'LFS (45mg/kg)+APS (150mg/kg)' and 'LFS (135mg/kg)+APS (450mg/kg)' displayed hepatoprotective and antioxidative effects than the administration of either LFS or APS, as evident by lower (p <0.005 or 0.001) levels of serum ALT, AST, ALP and hepatic MDA (p <0.001) concentration, as well as higher SOD (p <0.05 or 0.005), CAT activities (p <0.01 or 0.005), GSH concentration (p <0.05 or 0.005) compared to the toxin treated group. |
1(0,0,0,1) | Details |
| 18786523 | Jayakumar T, Sakthivel M, Thomas PA, Geraldine P: Pleurotus ostreatus, an oyster mushroom, decreases the oxidative stress induced by carbon tetrachloride in rat kidneys, heart and brain. Fundam Clin Pharmacol. 2005 Aug;19(4):491-6. Quantitative and qualitative analysis of catalase (CAT), superoxide dismutase (SOD), peroxidase (Gpx) and glutathione-S-transferase (GST) revealed lower activities of these antioxidant enzymes in the kidneys, heart and brain of rats exposed to CCl4. |
1(0,0,0,1) | Details |
| 15267142 | Bhandarkar M, Khan A: Protective effect of Lawsonia alba Lam., against CCl4 induced hepatic damage in albino rats. Nat Prod Commun. 2009 Jun;4(6):765-8. The oral administration in varying doses of aqueous suspension of extract of L. alba, bark extract to rats for 10 days afforded good hepatoprotection against CCl4 induced elevation in serum marker enzymes, serum liver lipid peroxidation and reduction in total serum protein, liver peroxidase, glutathione-s-transferase, superoxide dismutase and catalase activity. |
1(0,0,0,1) | Details |
| 19405380 | Preethi KC, Kuttan R: Hepato and reno protective action of Calendula officinalis L. flower extract. J Pharm Pharmacol. 2006 Jan;58(1):143-52. Treatment with the extract produced enhancement of antioxidant enzymes--superoxide dismutase and catalase and |
1(0,0,0,1) | Details |
| 19913046 | Shim JY, Kim MH, Kim HD, Ahn JY, Yun YS, Song JY: Protective action of the immunomodulator ginsan against carbon tetrachloride-induced liver injury via control of oxidative stress and the inflammatory response. J Ethnopharmacol. 2007 Sep 25;113(3):498-502. Epub 2007 Jul 10. The hepatoprotective effect of ginsan was attributed to induction of anti-oxidant protein contents, such as superoxide dismutase (SOD), catalase, and peroxidase (GPX) as well as restoration of the hepatic (GSH) concentration. |
1(0,0,0,1) | Details |
| 18598162 | Wu SJ, Lin YH, Chu CC, Tsai YH, Chao JC: or saikosaponin a improves hepatic antioxidant capacity and protects against CCl4-induced liver injury in rats. World J Gastroenterol. 2005 Aug 21;11(31):4822-6. The CU+SS group showed reversal of the impaired hepatic superoxide dismutase activity and an increase in total level. |
1(0,0,0,1) | Details |
| 18385828 | Ohta Y, Ohashi K, Matsura T, Tokunaga K, Kitagawa A, Yamada K: Octacosanol attenuates disrupted hepatic reactive species metabolism associated with acute liver injury progression in rats intoxicated with carbon tetrachloride. Br J Nutr. 2009 Dec;102(12):1767-75. Epub . Octacosanol (10, 50 or 100 mg/kg) administered orally to CCl (4)-intoxicated rats at 6 h after intoxication attenuated the increased activities of serum transaminases and the increased hepatic myeloperoxidase and xanthine oxidase activities and LPO concentration and the decreased hepatic superoxide dismutase and catalase activities and GSH concentration found at 24 h after intoxication dose-dependently. |
1(0,0,0,1) | Details |
| 17886222 | Ahn TH, Yang YS, Lee JC, Moon CJ, Kim SH, Jun W, Park SC, Kim JC: Ameliorative effects of pycnogenol on carbon tetrachloride-induced hepatic oxidative damage in rats. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2006 Jul;18(7):417-20. In addition, increased malondialdehyde (MDA) concentration, (GSH) content, and decreased catalase, superoxide dismutase (SOD) and glutathione-S-transferase (GST) activities were observed in the hepatic tissues. |
1(0,0,0,1) | Details |
| 16011737 | Srinivasan M, Rukkumani R, Ram Sudheer A, Menon VP: a natural protector against carbon tetrachloride-induced toxicity. J Ethnopharmacol. 2004 Mar;91(1):61-4. The activities of liver markers transaminase, transaminase, alkaline phosphatase, gamma-glutamyl transferase), lipid peroxidative index (thiobarbituric acid-reactive substances, hydroperoxides, protein carbonyl content), the antioxidant status (superoxide dismutase, catalase, peroxidase and were used as biomarkers to monitor the protective role of FA. |
1(0,0,0,1) | Details |
| 17879412 | Xue H, Guo H, Li YC, Hao ZM: Heme oxygenase-1 induction by hemin protects liver cells from ischemia/reperfusion injury in cirrhotic rats. Phytother Res. 2007 Nov;21(11):1015-9. improved serum manganese superoxide dismutase (MnSOD) (6 h: 131.3 +/- 17.6 vs 107.0 +/- 13.9, P < 0.01; 12 h: 141.4 +/- 12.5 vs 118.3 +/- 10.2, P < 0.01), lessened liver cell injury, decreased caspase-3 (6 h: 166.7 +/- 8.1 vs 145.5 +/- 14.6, P < 0.01; 12 h: 172.8 +/- 3.8 vs 148.0 +/- 6.5, P < 0.01) and NF-kappaB expression (6 h: 150.2 +/- 8.6 vs 139.7 +/- 6.0, P < 0.01; 12 h: 151.1 +/- 5.9 vs 148.1 +/- 5.3, P > 0.05) and serum alanine aminotransferase (ALT) (6 h: 413.3 +/- 104.1 vs 626.8 +/- 208.2, P < 0.01; 12 h: 322.2 +/- 98.8 vs 425.8 +/- 115.4, P < 0.05), aspartate aminotransferase (AST) (6 h: 665.2 +/- 70.1 vs 864.3 +/- 70.4, P < 0.01; 12 h: 531.1 +/- 98.6 vs 664.4 +/- 115.6, P < 0.01), malondialdehyde (MDA) levels (6 h: 11.1 +/- 2.17 vs 13.5 +/- 2.01, P < 0.01; 12 h: 9.36 +/- 1.10 vs 10.8 +/- 1.62, P < 0.05) in the I/R + hemin group when compared with the I/R group. |
1(0,0,0,1) | Details |
| 16552805 | Yang XJ, Liu J, Ye LB, Yang F, Ye L, Gao JR, Wu ZH: In vitro and in vivo protective effects of proteoglycan isolated from mycelia of Ganoderma lucidum on carbon tetrachloride-induced liver injury. World J Gastroenterol. 2006 Mar 7;12(9):1379-85. The activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined with an automatic multifunction-biochemical analyzer and the levels of superoxide dismutase (SOD) and TNF-alpha were determined following the instructions of SOD kit and TNF radioimmunoassay kit. |
1(0,0,0,1) | Details |
| 18481019 | Kang KS, Kim ID, Kwon RH, Lee JY, Kang JS, Ha BJ: The effects of fucoidan extracts on CCl (4)-induced liver injury. BMC Complement Altern Med. 2006 Sep 30;6:33. The aim of this study was to elucidate the antioxidant properties of fucoidan extracts (FE) against CCl (4)-induced oxidative stress by monitoring the levels of transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and peroxidase (GPx). |
1(0,0,0,1) | Details |
| 19524009 | Hsu YW, Tsai CF, Chen WK, Lu FJ: Protective effects of seabuckthorn (Hippophae rhamnoides L.) seed oil against carbon tetrachloride-induced hepatotoxicity in mice. Food Chem Toxicol. 2009 Sep;47(9):2281-8. Epub 2009 Jun 11. Moreover, the treatment of SBT seed oil was also found to significantly increase the activities of superoxide dismutase (SOD), catalase, peroxidase (GSH-Px), glutathione reductase (GSH-Rd), and GSH content in liver up to 134%. |
1(0,0,0,1) | Details |
| 18777138 | Smyth R, Lane CS, Ashiq R, Turton JA, Clarke CJ, Dare TO, York MJ, Griffiths W, Munday MR: Proteomic investigation of urinary markers of carbon-tetrachloride-induced hepatic fibrosis in the Hanover Wistar rat. Indian J Exp Biol. 2003 Dec;41(12):1447-51. Using in-gel trypsin digest and nano-scale liquid chromatography combined with electrospray ionisation tandem mass spectrometry, protein spots were identified as /zinc superoxide dismutase, D: -dopachrome tautomerase, beta-2-microglobulin and neutrophil gelatinase associated lipocalin. |
1(0,0,0,1) | Details |
| 19327382 | Tung YT, Wu JH, Huang CC, Peng HC, Chen YL, Yang SC, Chang ST: Protective effect of Acacia confusa bark extract and its active compound against carbon tetrachloride-induced chronic liver injury in rats. Food Chem Toxicol. 2009 Jun;47(6):1385-92. Epub 2009 Mar 25. CCl (4)-induced hepatic pathological damage and significantly increased the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and malondialdehyde (MDA) in plasma, and cytochrome P4502E1 (CYP2E1) protein expression in hepatic samples, and decreased the activities of superoxide dismutase (SOD), peroxidase (GPX) and catalase (CAT) in erythrocytes. |
1(0,0,0,1) | Details |
| 18418968 | Chen Y, Tao YY, Li FH, et al: [Effects of Danggui Buxue Decoction on liver fibrosis and hepatic lipid peroxidation in rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Jan;28(1):39-42. METHODS: Liver fibrosis model was established in 28 rats by the combination of injecting carbon tetrachloride (CCl4) subcutaneously and feeding high lipid and low protein diet. The inflammation and fatty degeneration in rat liver tissues were examined with HE staining; the collagen deposition observed with sirius red; the liver function including serum level of transaminase (ALT), aspartate aminotransferase (AST), albumin (Alb) and total (TBil) were determined using corresponding test kits; the hepatic lipid peroxidation indexes, including triglyceride (TG), superoxide dismutase (SOD) and malondialdehyde (MDA) were measured by biochemical methods; the hepatic (Hyp) content was detected with Jamall's method and the expression of collagen type I was analyzed by Western blotting. |
1(0,0,0,1) | Details |
| 18489120 | Dani C, Bonatto D, Salvador M, Pereira MD, Henriques JA, Eleutherio E: Antioxidant protection of and in Saccharomyces cerevisiae. J Agric Food Chem. 2008 Jun 11;56(11):4268-72. Epub 2008 May 20. In this work, the capacity of and to protect the eukaryotic microorganism Saccharomyces cerevisiae against oxidative stress caused by different agents, peroxide, carbon tetrachloride, and cadmium, was evaluated. By using mutant strains deficient in specific antioxidant defense systems (superoxide dismutases, catalase, or it was observed that increased H2O2 tolerance produced by both polyphenols was associated with catalase, as well as the rise in survival rates caused by under CCl4. |
1(0,0,0,1) | Details |
| 16823256 | Ko JH, Lim KT: Glycoprotein isolated from Ulmus davidiana NAKAI protects against carbon tetrachloride-induced liver injury in the mouse. J Pharmacol Sci. 2006 Jul;101(3):205-13. Epub 2006 Jul 6. We evaluated the activities of alanine aminotransferase (ALT), lactate dehydrogenase (LDH), thiobarbituric acid-reactive substances (TBARS), and antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), peroxidase (GPx)] activities in CCl4-treated mice. |
1(0,0,0,1) | Details |
| 18664124 | Bezborodkina NN, Okovityi SV, Kudriavtseva MV, Kirik OV, Zarubina IV, Kudriavtsev BN: [Morphometry of hepatocyte mitochondrial apparatus in normal and cirrhotic rat liver]. Tsitologiia. 2008;50(3):228-36. Activities of superoxide dismutase and catalase in the cirrhotic liver were lower than in the normal liver were lower than in the normal liver by 16 and 23 %, respectively. |
1(0,0,0,1) | Details |
| 17431769 | Amalia PM, Possa MN, Augusto MC, Francisca LS: prevents oxidative stress in cirrhotic rats. Int J Exp Pathol. 2007 Oct;88(5):361-76. Our aim was to study the protective effect of quercitin on liver cirrhosis induced by carbon tetrachloride (CCl (4)) in rats and its relationship with liver morphology. Blood samples were taken for determination of serum indicators (ALT, AST, total conjugated factor V) and the livers were dissected out and divided into two parts: one was homogenized and the supernatant was used for measurement of superoxide dismutase (SOD), catalase, and peroxidase (GPx) activities, as well as lipid peroxidation. |
1(0,0,0,1) | Details |
| 19022872 | Ogeturk M, Kus I, Pekmez H, Yekeler H, Sahin S, Sarsilmaz M: Inhibition of carbon tetrachloride-mediated apoptosis and oxidative stress by in experimental liver fibrosis. Cell Stress Chaperones. 2004 Mar;9(1):58-68. Some of the liver tissue specimens were used for determination of malondialdehyde (MDA), superoxide dismutase (SOD) and peroxidase (GSH-Px) levels. |
1(0,0,0,1) | Details |
| 14750197 | Farag RS, Shalaby AS, El-Baroty GA, Ibrahim NA, Ali MA, Hassan EM: Chemical and biological evaluation of the essential oils of different Melaleuca species. Acta Pharm. 2007 Jun;57(2):241-8. The essential oil of M. armillaris exhibited a marked antioxidant effect, it improved and superoxide dismutase parameters so it can be used as a free radical suppressor. The effects of the essential oils on the antioxidant system status in carbon tetrachloride treated animals were studied. |
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| 19595748 | Chan WH, Liao JW, Chou CP, Chan PK, Wei CF, Ueng TH: Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol. Arch Pharm Res. 2008 May;31(5):622-7. Epub 2008 May 15. The treatments also increased glutathione S-transferase and superoxide dismutase activities in liver cytosol. |
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| 16278809 | Ohta Y, Imai Y, Matsura T, Kitagawa A, Yamada K: Preventive effect of neutropenia on carbon tetrachloride-induced hepatotoxicity in rats. J Appl Toxicol. 2006 Mar-Apr;26(2):178-86. The liver of CCl4 -treated rats showed an increase in the concentration of thiobarbituric acid reactive substances (TBARS), an index of lipid peroxidation, and decreases in superoxide dismutase (SOD) activity and (GSH) concentration at 6 h after the intoxication followed by a further increase in TBARS concentration and further decreases in SOD activity and GSH concentration at 24 h with increased xanthine oxidase (XO) activity at 24 h. |
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| 19118616 | Khan MR, Rizvi W, Khan GN, Khan RA, Shaheen S: Carbon tetrachloride-induced nephrotoxicity in rats: protective role of Digera muricata. Food Chem Toxicol. 2009 Aug;47(8):2031-6. Epub 2009 May 27. Activity of antioxidant enzymes; catalase, peroxidase, superoxide dismutase and (GSH) were decreased while thiobarbituric acid reactive substances (TBARSs) were increased with CCl (4) treatment. |
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| 15511216 | Das RK, Das S, Bhattacharya S: Protective effect of diphenylmethyl selenocyanate against carbon tetrachloride-induced hepatotoxicity in vivo. Biosci Biotechnol Biochem. 2009 Apr 23;73(4):849-54. Epub 2009 Apr 7. Treatment with Se compound was found to upregulate different phase II detoxifying enzymes (catalase, superoxide dismutases, and glutathione transferase) in liver of mice challenged with different doses of CCl (4) as compared to the CCl (4) control, when measured after 24 hours of CCl (4) treatment (p < 0.01). |
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| 19938218 | Chao J, Lee MS, Amagaya S, Liao JW, Wu JB, Ho LK, Peng WH: Hepatoprotective effect of shidagonglao on acute liver injury induced by carbon tetrachloride. Phytother Res. 2006 Nov;20(11):935-40. Moreover, the SDGL (EtOH) (100 and 500 mg/kg) increased the activities of anti-oxidative enzymes, superoxide dismutase (SOD), peroxidase (GPx) and glutathione reductase (GRd) and decreased malondialdehyde (MDA) level in liver, as compared to those in the CCl (4)-treated group. |
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| 20350579 | Hsu YW, Tsai CF, Chuang WC, Chen WK, Ho YC, Lu FJ: Protective effects of hydride against carbon tetrachloride-induced hepatotoxicity in mice. Biol Pharm Bull. 2007 Jan;30(1):44-7. Moreover, the -hydride treatment was also found to significantly increase the activities of superoxide dismutase (SOD), catalase, and peroxidase (GSH-Px), as well as increase the GSH content, in the liver. |
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| 18583118 | Mehmetcik G, Ozdemirler G, Kocak-Toker N, Cevikbas U, Uysal M: Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress. J Clin Biochem Nutr. 2008 Mar;42(2):118-25. Hepatic superoxide dismutase (SOD) activities remained unchanged, but peroxidase (GSH-Px) and glutathione transferase (GST) activities decreased following CCl4 treatment. |
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| 19446540 | Singh BN, Singh BR, Sarma BK, Singh HB: Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark. Food Chem Toxicol. 2007 Apr;45(4):656-61. Epub 2006 Nov 2. Chemopreventive potential of Acacia nilotica bark extract (ANBE) against single intraperitoneal injection of N-nitrosodiethylamine (NDEA, 200mg/kg) followed by weekly subcutaneous injections of carbon tetrachloride (CCl (4), 3 ml/kg) for 6 weeks induced hepatocellular carcinoma (HCC) in rats was studied. Additionally, ANBE also increased the activities of antioxidant enzymes viz., catalase (CAT), superoxide dismutase (SOD), peroxidase (GPx), and glutathione-S-transferase (GST) in the liver of NDEA-administered rats. |
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| 19634318 | Lee MK, Kim SH, Yang H, Lim DY, Ryu JH, Lee ES, Jew SS, Park HG, Sung SH, Kim YC: Asiatic acid derivatives protect primary cultures of rat hepatocytes against carbon tetrachloride-induced injury via the cellular antioxidant system. Glycobiology. 2008 Jan;18(1):97-103. Epub 2007 Oct 27. Our findings showed that AS-10 and AS-14 preserved the level of and the activities of antioxidant enzymes such as glutathione reductase, peroxidase, superoxide dismutase and catalase. |
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| 16914248 | Jayakumar T, Ramesh E, Geraldine P: Antioxidant activity of the oyster mushroom, Pleurotus ostreatus, on CCl (4)-induced liver injury in rats. World J Gastroenterol. 2005 Oct 7;11(37):5795-800. Quantitative and qualitative analysis of catalase (CAT), superoxide dismutase (SOD) and peroxidase (Gpx) revealed lower activities of these antioxidant enzymes in the liver of CCl (4)-administered rats. |
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| 15925388 | Wang H, Wei W, Wang NP, Gui SY, Wu L, Sun WY, Xu SY: ameliorates carbon tetrachloride-induced hepatic fibrogenesis in rats via inhibition of oxidative stress. J Ethnopharmacol. 2008 Oct 30;120(1):51-5. Epub 2008 Aug 7. Malondialdehyde (MDA), an end product of lipid peroxidation, and peroxidase (GSH-px) and superoxide dismutase (SOD) levels were evaluated in tissue homogenates by spectrophotometry. |
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| 16438391 | Ramkumar KM, Anuradha CV: Short-term dietary restriction modulates liver lipid peroxidation in carbon tetrachloride-intoxicated rats. J Ethnopharmacol. 2009 Feb 25;122(1):91-9. Epub 2008 Dec 11. The enzymic antioxidants superoxide dismutase, catalase, peroxidase and the non-enzymic antioxidant were significantly increased in both groups. |
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| 14969415 | Jeon TI, Hwang SG, Lim BO, Park DK: Extracts of Phellinus linteus grown on germinated brown rice suppress liver damage induced by carbon tetrachloride in rats. Toxicol Appl Pharmacol. 2010 Feb 1;242(3):318-25. Epub 2009 Nov 11. Catalase and superoxide dismutase activities were significantly decreased to 55% and 39% by CCl4 administration, but EPB blocked this effect, resulting in enzyme activities at control levels. |
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| 20021039 | Dhawan D, Sen T, Dani V: Effectiveness of in Modulating the CCl (4) - Induced Oxidative Stress in Rat Liver. Biotechnol Lett. 2003 Dec;25(24):2093-6. The present study was designed to evaluate the role of zinc on the enzymes involved in oxidative defense mechanism in conditions of carbon tetrachloride (CCl (4)) -induced rat liver toxicity. Animals given CCl (4) treatment alone showed a significant increase in the activities of superoxide dismutase (SOD), catalase, peroxidase (GPx), and the concentration of malondialdehyde (MDA) product, whereas a significant depression was observed in the levels of reduced glutathione (GSH). |
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| 17175085 | Bhattacharjee R, Sil PC: Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties. Dig Dis Sci. 2007 Oct;52(10):2616-21. Epub 2007 Apr 12. Administration of CCl (4) increased the serum glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP) levels of mice sera along with increased lipid peroxidation and reduced levels of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) in the liver. |
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| 19152825 | Mohammadi M, Yazdanparast R: Methoxy VO-salen complex: in vitro antioxidant activity, cytotoxicity evaluation and protective effect on CCl4-induced oxidative stress in rats. Food Chem Toxicol. 2009 Apr;47(4):716-21. Epub 2008 Dec 29. In an in vivo approach, the protective effect of MetVO-salen against CCl (4)-induced oxidative stress in rats was also investigated in terms of superoxide dismutase (SOD) and catalase (CAT) activities, as well as in terms of the levels of malondialdehyde (MDA) and glutathione (GSH). |
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| 19899326 | Adaramoye OA: Comparative effects of and kolaviron (a biflavonoid from Garcinia kola) on carbon tetrachloride-induced renal oxidative damage in mice. Pak J Biol Sci. 2009 Aug 15;12(16):1146-51. Furthermore, CCl4-intoxication decreased the levels of renal (GSH), superoxide dismutase (SOD) and catalase (CAT) by 44, 56 and 43%, respectively. |
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| 19581077 | Adesanoye OA, Farombi EO: Hepatoprotective effects of Vernonia amygdalina (astereaceae) in rats treated with carbon tetrachloride. Rejuvenation Res. 2008 Feb;11(1):43-62. Similarly, administration of the extract increased the activities of the antioxidant enzymes: superoxide dismutase, glutathione S-transferase and concentration significantly at 500 mg/kg (P <0.05) and catalase activity at 500-1000 mg/kg doses. |
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| 16270387 | Chen L, Pan DD, Zhou J, Jiang YZ: Protective effect of -enriched Lactobacillus on CCl4-induced liver injury in mice and its possible mechanisms. Biol Res. 2009;42(1):93-8. Epub 2009 Jun 11. AIM: To study the protective effects and mechanisms of Se-enriched lactobacillus on liver injury caused by carbon tetrachloride (CCl4) in mice. Then the activities of the following liver tissue injury-associated enzymes including peroxidase (GSH-Px), superoxide dismutase (SOD), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as well as malondialdehyde (MDA) content were assayed. |
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| 18358653 | Wang T, Sun NL, Zhang WD, Li HL, Lu GC, Yuan BJ, Jiang H, She JH, Zhang C: Protective effects of dehydrocavidine on carbon tetrachloride-induced acute hepatotoxicity in rats. J Ethnopharmacol. 2008 May 8;117(2):300-8. Epub 2008 Feb 14. In addition, pre- and post-treatment with DC also significantly prevented formation of hepatic malondialdehyde (MDA), depletion of peroxidase (GPx) and depression of superoxide dismutase (SOD) in the liver of CCl4-intoxicated rats. |
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| 16117622 | Shahjahan M, Vani G, Devi CS: Protective effect of Indigofera oblongifolia in CCl4-induced hepatotoxicity. Am J Chin Med. 2009;37(6):1085-97. The present study aimed at assessing the protective effect of Indigofera oblongifolia on carbon tetrachloride (CCl4-induced hepatotoxicity. Antioxidant status was significantly lowered in CCl4-treated animals with a significant (P < .001) increase in the levels of lipid peroxides [thiobarbituric acid-reactive substances (TBARS)], significantly lower levels of (GSH), and lowered activities of superoxide dismutase (SOD), catalase (CAT), and GSH peroxidase (GPx). |
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| 18829979 | Lavina B, Gracia-Sancho J, Rodriguez-Vilarrupla A, Chu Y, Heistad DD, Bosch J, Garcia-Pagan JC: Superoxide dismutase gene transfer reduces portal pressure in CCl4 cirrhotic rats with portal hypertension. Toxicol Mech Methods. 2006;16(1):37-40. |
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| 15793860 | Xu DH, Mei XT, Chen Y, Li YM, Lv JY, Xu SB: Protective effects of 5,4'-dihydroxy-3',5'-dimethoxy-7-O-beta-D -glucopyranosyloxy- on experimental hepatic injury. Zhongguo Dang Dai Er Ke Za Zhi. 2007 Feb;9(1):54-8. METHODS: Models of rat acute hepatic injury induced by carbon tetrachloride (CCl (4)) administration, rat hepatic fibrosis induced by thioacetamide, injury of primary cultured rat hepatocytes induced by CCl (4), respectively, were established. After treated with RF, content of serum transaminase (ALT), aspartate aminotransferase (AST) and albumin (Alb), (HA), the activity of peroxidase (GSH-Px), superoxide dismutase (SOD), and (Hyp) were measured and liver tissue was observed pathologically by hematoxylin-eosin (HE) staining. |
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| 16810758 | Shi ZM, Feng P, Jiang DQ, Wang XJ: Mistletoe alkali inhibits peroxidation in rat liver and kidney. . Chem Biol Interact. 2010 Mar 19. METHODS: The antioxidant effect of mistletoe alkali on the oxidative stress induced by carbon tetrachloride (CCl4) in rats was investigated. Also, the level of (GSH), and activities of glutathione reductase (GR), peroxidase (GSPx), superoxide dismutase (SOD), and glutathione-S-transferase (GST) in liver and kidney were determined. |
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| 19596425 | Ko WS, Hsu SL, Chyau CC, Chen KC, Peng RY: Compound Cordyceps TCM-700C exhibits potent hepatoprotective capability in animal model. Food Chem Toxicol. 2007 May;45(5):817-26. Epub 2006 Nov 11. A herbal preparation "Compound Codyceps-TCM-700C (CC-700C)" was tested for hepatoprotective effect against the carbon tetrachloride induced liver damages in Sprague-Dawley rat model for a period of 6-weeks. Moreover, although levels of (GSH), glutathione reductase (GSH-Rd), and superoxide dismutase (SOD) were equally maintained by these three preparations, peroxidase (GSH-Px) was suppressed only by H-TCM, and SOD only by Silymarin. |
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| 18313245 | Yuan LP, Chen FH, Ling L, Dou PF, Bo H, Zhong MM, Xia LJ: Protective effects of total flavonoids of Bidens pilosa L. (TFB) on animal liver injury and liver fibrosis. Indian J Physiol Pharmacol. 2007 Oct-Dec;51(4):361-7. The hepatoprotective effects of total flavonoids of Bidens pilosa L. (TFB), a traditional Chinese medicine were evaluated in carbon tetrachloride (CCl (4))-induced liver injury in mice and rats. Liver index (liver weight/body weight), serum levels of transaminases (alanine aminotransferase, ALT and aspartate aminotransferase, AST), hepatic malondialdehyde (MDA) content, superoxide dismutase (SOD) and peroxidase (GSH-Px) activities were evaluated following the 10 days treatment in mice. |
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| 19854235 | Hamza AA: Ameliorative effects of Moringa oleifera Lam seed extract on liver fibrosis in rats. Toxicol In Vitro. 2008 Mar;22(2):376-85. Epub 2007 Oct 14. The activity of superoxide dismutase as well as the content of both malondialdehyde and protein carbonyl, which are oxidative stress markers, were reversed after treatment with Moringa. Liver fibrosis was induced by the oral administration of 20% carbon tetrachloride (CCl (4)), twice weekly and for 8 weeks. |
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| 17973934 | Zhang BJ, Xu D, Guo Y, Ping J, Chen LB, Wang H: Protection by and anti-oxidant mechanism of against rat liver fibrosis induced by multiple hepatotoxic factors. Toxicology. 2008 Jun 3;248(1):18-24. Epub 2008 Mar 20. Serum levels of alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST), hepatic activity of superoxide dismutase (SOD) and hepatic malondialdehyde (MDA) and hepatic (Hyp) content were determined. |
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| 18538978 | Veigas JM, Shrivasthava R, Neelwarne B: Efficient amelioration of carbon tetrachloride induced toxicity in isolated rat hepatocytes by Syzygium cumini Skeels extract. Food Chem Toxicol. 2006 Dec;44(12):1989-96. Epub 2006 Jul 12. Both peel and pulp extract appear to offer protection to rat hepatocytes through GPx along with other biological pathways independent of catalase and superoxide dismutase. |
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| 18951966 | Zou YH, Yang Y, Li J, Wu Q, Li WP, Lu JT, Roberts MS: Potential therapeutic effects of a traditional Chinese formulation, BJ-JN, on liver fibrosis induced by carbon tetrachloride in rats. J Med Food. 2005 Summer;8(2):261-5. Evaluated with liver and spleen index, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), (HA), (NO), hepatic malondialdehyde (MDA) content and superoxide dismutase (SOD) activity, as well as with histopathologic changes of liver. |
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| 17615005 | Mahmoud KZ, Hijazi AA: Effect of and/or E on plasma enzymatic antioxidant systems and total antioxidant capacity of broiler chickens challenged with carbon tetrachloride. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Jan;26(1):63-7. Superoxide dismutase (SOD) and peroxidase (GPX) activities as well as total antioxidant (TAO) level were analysed before and after CCl (4) challenge. |
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| 18695788 | Martinez JA, Ramos SG, Meirelles MS, Verceze AV, Arantes MR, Vannucchi H: [Effects of on bleomycin-induced lung injury: a preliminary study]. Toxicol Ind Health. 2008 May;24(4):201-8. METHODS: Male Wistar rats, with mean weight of 250 g, were used in four experimental models: inhaled carbon tetrachloride; intraperitoneal carbon tetrachloride; partial portal vein ligation; and bile duct ligation (BDL). The following variables were measured: transaminase levels; blood gases; lipoperoxidation, using thiobarbituric acid reactive substances (TBARS) and chemiluminescence; and levels of superoxide dismutase (SOD) anti-oxidant activity. |
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| 17869397 | Guo TT, Xu HL, Zhang LX, Zhang JP, Guo YF, Gu JW, He PM: In vivo protective effect of Porphyra yezoensis polysaccharide against carbon tetrachloride induced hepatotoxicity in mice. Exp Toxicol Pathol. 2008 Sep;60(6):475-80. Epub 2008 Jun 25. Levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and liver homogenate, content of malondialdehyde (MDA), activities of total superoxide dismutase (T-SOD) in liver were measured by biochemical methods. |
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| 18436364 | Lee KJ, Choi JH, Khanal T, Hwang YP, Chung YC, Jeong HG: Protective effect of phenethyl ester against carbon tetrachloride-induced hepatotoxicity in mice. Exp Toxicol Pathol. 2010 Mar;62(2):197-206. Epub 2009 Jul 5. In addition, CAPE attenuated the CCl (4)-mediated depletion of antioxidant enzyme (catalase, superoxide dismutase and glutathione-S-transferase) activities. |
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| 17803529 | Subramanian P, Mirunalini S, Dakshayani KB, Pandi-Perumal SR, Trakht I, Cardinali DP: Prevention by of hepatocarcinogenesis in rats injected with N-nitrosodiethylamine. Toxicol Lett. 2009 Oct 28;190(2):150-5. Epub 2009 Jul 10. To evaluate the chemopreventive function of in this experimental model, Wistar male rats received a single i.p. injection of NDEA or vehicle followed by weekly s.c. injections of carbon tetrachloride or vehicle for 6 weeks. The activity of superoxide dismutase (SOD), catalase (CAT), peroxidase (GPx) and glutathione S-transferase (GST) was assessed in liver and erythrocyte fraction of NDEA-treated rats. |
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| 19477216 | Tsai CF, Hsu YW, Chen WK, Chang WH, Yen CC, Ho YC, Lu FJ: Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol. 2010 Jan;48(1):345-55. Epub 2009 Oct 23. In addition, CCl (4) also significantly decreased the activities of superoxide dismutase (SOD) and peroxidase (GSH-Px). |
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| 16804984 | He SX, Luo JY, Wang YP, Wang YL, Fu H, Xu JL, Zhao G, Liu EQ: Effects of extract from Ginkgo biloba on carbon tetrachloride-induced liver injury in rats. Chem Biol Interact. 2009 Sep 14;181(1):20-8. Epub 2009 May 14. Compared to the CCl (4)-treated group, the levels of plasma glutathoine peroxidase (Se-GSH-Px), superoxide dismutase (SOD) and malondialdehyde (MDA) were strikingly improved also in EGb-protected group (P < 0.05, P < 0.01). |
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| 20138953 | Lee BJ, Senevirathne M, Kim JS, Kim YM, Lee MS, Jeong MH, Kang YM, Kim JI, Nam BH, Ahn CB, Je JY: Protective effect of fermented sea tangle against and carbon tetrachloride-induced hepatic damage in Sprague-Dawley rats. Life Sci. 2005 Aug 26;77(15):1902-15. Hepatotoxicity was evaluated by measuring the serum levels of glutamic transaminase (GPT), gamma glutamyl transpeptidase (gamma-GT) and malondialdehyde (MDA) as well as the tissue levels of antioxidant enzyme such as superoxide dismutase (SOD), catalase (CAT) and peroxidase (GPx). |
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| 17900780 | Yang YS, Ahn TH, Lee JC, Moon CJ, Kim SH, Jun W, Park SC, Kim HC, Kim JC: Protective effects of Pycnogenol on carbon tetrachloride-induced hepatotoxicity in Sprague-Dawley rats. Gut. 2009 Jan;58(1):118-25. Epub 2008 Oct 1. Hepatotoxicity was assessed 24 h after the CCl4 treatment by measurement of serum aminotransferase (AST) and alanine aminotransferase (ALT) activities, hepatic malondialdehyde (MDA) and (GSH) concentrations, and catalase, superoxide dismutase (SOD), and glutathione-S-transferase (GST) activities. |
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| 19652474 | Sugiyama A, Suzuki K, Mitra S, Arashida R, Yoshida E, Nakano R, Yabuta Y, Takeuchi T: Hepatoprotective effects of paramylon, a beta-1, 3-D-glucan isolated from Euglena gracilis Z, on acute liver injury induced by carbon tetrachloride in rats. Food Chem Toxicol. 2008 Jan;46(1):380-7. Epub 2007 Aug 21. The treatment of paramylon recovered reductions of activity of hepatic superoxide dismutase, catalase and peroxidase induced by CCl (4). |
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| 20227265 | Coballase-Urrutia E, Pedraza-Chaverri J, Cardenas-Rodriguez N, Huerta-Gertrudis B, Edna Garcia-Cruz M, Ramirez-Morales A, Javier Sanchez-Gonzalez D, Maria Martinez-Martinez C, Camacho-Carranza R, Javier Espinosa-Aguirre J: Hepatoprotective effect of acetonic and methanolic extracts of Heterotheca inuloides against CCl (4)-induced toxicity in rats. Food Chem Toxicol. 2010 Mar 26. A model of hepatotoxicity by carbon tetrachloride (CCl (4)) in rats was used in order to evaluate the protective potential of the acetonic and methanolic extracts of Heterotheca inuloides. Furthermore, the decrease in the activity of several antioxidant enzymes including superoxide dismutase, catalase and peroxidase in CCl (4)-induced liver injury was alleviated by the pretreatment with H. inuloides methanolic extract or |
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| 16282059 | You SF, Zheng PY, Ji G, Wei HF, Zhao J, Zhu PT: [Protective effects of yanggan lidan granules on carbon tetrachloride-induced liver damage in mice]. Exp Toxicol Pathol. 2010 Mar 11. Then the levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as the contents of superoxide dismutase (SOD) and malondialdehyde (MDA) in liver tissues were detected. |
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| 15022720 | Jung SH, Lee YS, Lim SS, Lee S, Shin KH, Kim YS: Antioxidant activities of isoflavones from the rhizomes of Belamcanda chinensis on carbon tetrachloride-induced hepatic injury in rats. Arch Pharm Res. 2004 Feb;27(2):184-8. Both compounds also showed strong increase in the antioxidant enzymes such as hepatic cytosolic superoxide dismutase (SOD), catalase and peroxidase -px) activities in CCl4-intoxicated rats. |
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| 19621136 | Moselhy SS, Ali HK: Hepatoprotective effect of cinnamon extracts against carbon tetrachloride induced oxidative stress and liver injury in rats. Chin J Integr Med. 2009 Jun;15(3):204-9. Epub 2009 Jul 2. There was a significant elevation in the level of liver malondialdhyde (MDA), while the activities of antioxidant enzymes superoxide dismutase and catalase (SOD and CAT) were significantly decreased in CC1 (4) intoxicated rats. |
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| 19352025 | Quan J, Piao L, Xu H, Li T, Yin X: Protective effect of iridoid glucosides from Boschniakia rossica on acute liver injury induced by carbon tetrachloride in rats. Toxicol In Vitro. 2008 Sep;22(6):1440-6. Epub 2008 Apr 29. The liver antioxidative defense system, including superoxide dismutase (SOD), peroxidase (GPx) and glutathione reductase (GR), as well as the cytochrome P450 2E1 (CYP2E1) expression were suppressed, however. |
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| 18695789 | Vercelino R, Tieppo J, Forgiarini Junior LA, Dias AS, Marroni CA, Marroni NP: [Experimental models for assessment of pulmonary alterations in hepatopulmonary syndrome]. Clin Exp Pharmacol Physiol. 2008 Mar;35(3):303-9. Epub 2007 Oct 30. METHODS: Male Wistar rats, with mean weight of 250 g, were used in four experimental models: inhaled carbon tetrachloride; intraperitoneal carbon tetrachloride; partial portal vein ligation; and bile duct ligation (BDL). The following variables were measured: transaminase levels; blood gases; lipoperoxidation, using thiobarbituric acid reactive substances (TBARS) and chemiluminescence; and levels of superoxide dismutase (SOD) anti-oxidant activity. |
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| 14969348 | Lee S, Son D, Ryu J, Lee YS, Jung SH, Kang J, Lee SY, Kim HS, Shin KH: Anti-oxidant activities of Acanthopanax senticosus stems and their lignan components. Arch Pharm Res. 2004 Jan;27(1):106-10. The fraction from the water extract of the stems, when pretreated orally at 200 mg/kg/day for 7 consecutive days in rats, was demonstrated to exhibit significant increases in antioxidant enzyme activities such as hepatic cytosolic superoxide dismutase, catalase and peroxidase by 30.31, 19.82 and 155%, respectively. |
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| 19186041 | Domitrovic R, Jakovac H, Milin C, Radosevic-Stasic B: Dose- and time-dependent effects of on carbon tetrachloride-induced hepatotoxicity in mice. J Vet Med Sci. 2009 Jul;71(7):885-90. has also decreased oxidative stress produced by CCl (4), as suggested by improvement in the Cu/Zn superoxide dismutase activity. |
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| 18783728 | Zeashan H, Amresh G, Singh S, Rao CV: Hepatoprotective activity of Amaranthus spinosus in experimental animals. Regul Toxicol Pharmacol. 2007 Nov;49(2):101-6. Epub 2007 Feb 14. The hepatoprotective and antioxidant activity of 50% ethanolic extract of whole plant of Amaranthus spinosus (ASE) was evaluated against carbon tetrachloride (CCl4) induced hepatic damage in rats. Meanwhile, in vivo antioxidant activities as malondialdehyde (MDA), hydroperoxides, (GSH), superoxide dismutase (SOD) and catalase (CAT) were also screened which were also found significantly positive in a dose dependent manner. |
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| 17030452 | Lv P, Luo HS, Zhou XP, Chireyath Paul S, Xiao YJ, Si XM, Liu SQ: Thalidomide prevents rat liver cirrhosis via inhibition of oxidative stress. World J Gastroenterol. 2006 Jun 28;12(24):3924-8. The cirrhosis of rat was induced by intraperitoneal injection of carbon tetrachloride thrice weekly; meanwhile, thalidomide (10mg/kg or 100mg/kg) was given daily by intragastric administration for 8 weeks. The content of oxidative stress parameters, including superoxide dismutase, peroxidase, and malondialdehyde, in the liver was detected by biochemical assay. |
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| 18186586 | Chang HF, Lin YH, Chu CC, Wu SJ, Tsai YH, Chao JC: Protective effects of Ginkgo biloba, Panax ginseng, and Schizandra chinensis extract on liver injury in rats. Indian J Exp Biol. 2009 Mar;47(3):163-8. This study investigated the effects of the combined extracts of Ginkgo biloba, Panax ginseng, and Schizandra chinensis at different doses on hepatic antioxidant status and fibrosis in rats with carbon tetrachloride (CCl4)-induced liver injury. |
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| 17306079 | Huang J, Ren RN, Chen XM, Ye LY: [An experimental study on hepatotoxicity of in young rats] . J Environ Pathol Toxicol Oncol. 2004;23(4):287-96. The ones in the positive control group (Group E) were treated by injection of 10% carbon tetrachloride dissolved in olive oil subcutaneously at a dose of 5 mL/kg twice a week. |
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| 16945181 | Maiti K, Mukherjee K, Gantait A, Saha BP, Mukherjee PK: Enhanced therapeutic potential of -phospholipid complex in rats. J Pharm Pharmacol. 2006 Sep;58(9):1227-33. -phospholipid complex was prepared and assessed for antioxidant activity in carbon tetrachloride intoxicated rats at a dose level of 100 mg kg-1 (p.o.). Marker enzymes of liver, namely peroxidase, superoxide dismutase, catalase and thiobarbituric acid reactive substances, were measured to evaluate the antioxidant potential at the same dose level. |
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| 19429327 | Shen X, Tang Y, Yang R, Yu L, Fang T, Duan JA: The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities. J Bras Pneumol. 2008 Jul;34(7):453-60. Product of lipid peroxidation (MDA), activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (GSH-Px), and (GSH) contents were evaluated for oxidative stress in hepatic injury. |
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| 16114493 | Singab AN, Youssef DT, Noaman E, Kotb S: Hepatoprotective effect of flavonol glycosides rich fraction from Egyptian Vicia calcarata Desf. against CCl4-induced liver damage in rats. Exp Toxicol Pathol. 2009 Oct 14. The antioxidant activity of F-2 markedly ameliorated the antioxidant parameters including (GSH) content, peroxidase (GSH-Px), superoxide dismutase (SOD), plasma catalase (CAT) and packed erythrocytes glucose-6-phosphate dehydrogenase (G6PDH) to be comparable with normal control levels. |
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| 19822030 | Ozturk F, Gul M, Ates B, Ozturk IC, Cetin A, Vardi N, Otlu A, Yilmaz I: Protective effect of apricot (Prunus armeniaca L.) on hepatic steatosis and damage induced by carbon tetrachloride in Wistar rats. J Ethnopharmacol. 2008 Dec 8;120(3):452-7. Epub 2008 Oct 1. Malondialdehyde and total levels and catalase, superoxide dismutase and peroxidase activities were significantly changed in the CCl4 group and indicated increased oxidative stress. |
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| 19548269 | Ozturk IC, Ozturk F, Gul M, Ates B, Cetin A: Protective effects of on hepatotoxicity and oxidative stress caused by carbon tetrachloride in the liver of Wistar rats. Cell Biol Toxicol. 2006 Nov;22(6):381-91. Epub 2006 May 16. MDA, total (T.GSH) levels and superoxide dismutase (SOD), catalase (CAT), peroxidase (GSH-PX) activities were measured in the liver of all groups of rats and also serum amino transferase (ALT) and amino transferase (AST) activities were detected to determine liver functions in all groups of rats. |
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| 17169472 | Rudnicki M, Silveira MM, Pereira TV, Oliveira MR, Reginatto FH, Dal-Pizzol F, Moreira JC: Protective effects of Passiflora alata extract pretreatment on carbon tetrachloride induced oxidative damage in rats. Food Chem Toxicol. 2008 Nov;46(11):3417-21. Epub 2008 Aug 22. The pretreatment with the P. alata extract provided significant protection to liver, evidenced by lower degree of necrosis, decreased lipid peroxidation (TBARS) and higher catalase and superoxide dismutase activities. |
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| 19836219 | Quan J, Yin X, Xu H: Boschniakia rossica prevents the carbon tetrachloride-induced hepatotoxicity in rat. Nutr J. 2006 Dec 2;5:31. |
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| 16703270 | Noyan T, Komuroglu U, Bayram I, Sekeroglu MR: Comparison of the effects of and pentoxifylline on carbon tetrachloride-induced liver toxicity in mice. Exp Toxicol Pathol. 2009 Nov;61(6):581-9. Epub 2009 Jan 30. |
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| 15270078 | Lee KJ, Terada K, Oyadomari S, Inomata Y, Mori M, Gotoh T: Induction of molecular chaperones in carbon tetrachloride-treated rat liver: implications in protection against liver damage. Chin Med J. 2008 Jun 5;121(11):1010-4. |
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| 17244260 | Wu ZM, Wen T, Tan YF, Liu Y, Ren F, Wu H: Effects of salvianolic acid a on oxidative stress and liver injury induced by carbon tetrachloride in rats. World J Gastroenterol. 2007 Oct 28;13(40):5384-90. |
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| 16722379 | Min Q, Bai YT, Shu SJ, Ren P: [Protective effect of dl-tetrahydropalmatine on liver injury induced by carbon tetrachloride in mice]. Zhongguo Zhong Yao Za Zhi. 2006 Mar;31(6):483-4 The mice were killed 17 h after injection ip of CCl4, serum and aspartate aminotransferase (ALT and AST) activity were measured, and maleic dialdehyde (MDA) and superoxide dismutase (SOD) activity in liver were detected. |
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| 17877147 | Kujawska M, Jodynis-Liebert J, Ewertowska M, Adamska T, Matlawska I, Bylka W: Protective effect of Aquilegia vulgaris (L.) on carbon tetrachloride-induced oxidative stress in rats. J Ethnopharmacol. 2009 Apr 21;122(3):555-60. Epub 2009 Feb 7. The extract itself significantly enhanced superoxide dismutase activity. |
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| 17686593 | Srinivasan R, Chandrasekar MJ, Nanjan MJ, Suresh B: Antioxidant activity of Caesalpinia digyna root. Food Chem Toxicol. 2010 Apr;48(4):1123-8. Epub 2010 Feb 6. The CDM having the highest content of phenolic compounds and strong free radical scavenging effect when administered orally to male albino rats at 100, 200 and 400mg/kg body weight for 7 days, prior to carbontetrachloride (CCl (4)) treatment, caused a significant increase in the levels of catalase (CAT) and superoxide dismutase (SOD) and significant decrease in the levels of lipidperoxidation (LPO) in serum, liver and kidney in a dose dependent manner, when compared to CCl (4) treated control. |
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| 19742242 | Shaarawy SM, Tohamy AA, Elgendy SM, Elmageed ZY, Bahnasy A, Mohamed MS, Kandil E, Matrougui K: Protective effects of garlic and silymarin on NDEA-induced rats hepatotoxicity. J Ethnopharmacol. 2007 Sep 5;113(2):284-91. Epub 2007 Jun 26. BACKGROUND: The present study was conducted to investigate the chemopreventive effects of garlic extract and silymarin on N-nitrosodiethylamine (NDEA) and carbon tetrachloride (CCl (4))-induced hepatotoxicity in male albino rats. Serum transaminase (AST), transaminase (ALT), alkaline phosphatase (ALP), hepatic lipid peroxidation (LPO), superoxide dismutase (SOD), (GSH), glutathione-S-transferase (GST) and glutathione reductase (GSR) were measured. |
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| 15902742 | Gui SY, Wei W, Wang H, Wu L, Sun WY, Wu CY: Protective effect of fufanghuangqiduogan against acute liver injury in mice. Am J Chin Med. 2007;35(5):793-804. METHODS: ALI was successfully induced by injecting carbon tetrachloride (CCl4) intraperitoneally and by tail vein injection of Bacillus Calmette Guerin (BCG) and lipopolysaccharide (LPS) in mice, respectively. At the end of the experiment, levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), content of malondialdehyde (MDA), activities of superoxide dismutase (SOD) and peroxidase (GSH-px) in liver homogenate were measured by biochemical methods. |
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| 20227401 | Ou Y, Zheng S, Lin L, Jiang Q, Yang X: Protective effect of C-phycocyanin against carbon tetrachloride-induced hepatocyte damage in vitro and in vivo. Cell Biochem Funct. 2009 Jul;27(5):309-15. C-PC also showed the following positive effects: prevent the CCl (4)-induced overproduction of intracellular reactive species (ROS) and malondialdehyde (MDA); prevent changes in superoxide dismutase (SOD) activity; and reduce (GSH) level. |
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| 19857077 | Dani C, Oliboni LS, Umezu FM, Pasquali MA, Salvador M, Moreira JC, Henriques JA: Antioxidant and antigenotoxic activities of purple grape juice--organic and conventional--in adult rats. J Ethnopharmacol. 2006 Apr 6;104(3):322-7. Epub 2005 Oct 18. The aim of this study was to evaluate the protection of organic and conventional purple grape juices in brain, liver, and plasma from adult Wistar rats (7 months old) against the oxidative damage provoked by carbon tetrachloride (CCl (4)). CCl (4) caused an increase in catalase activity in cerebral cortex, hippocampus, and substantia nigra and in superoxide dismutase activity in substantia nigra. |
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| 16381635 | Liu SQ, Yu JP, He L, Yu HG, Luo HS: [Effects of nuclear factor kappaB and transforming growth factor beta1 in the anti-liver fibrosis process using Ginkgo biloba extract]. Fitoterapia. 2010 Jan;81(1):1-7. Epub 2009 Jul 8. Malondialdehyde (MDA), superoxide dismutase (SOD) and peroxidase (GSH-Px) in liver tissues and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the sera were also examined. |
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| 16117609 | Kim NY, Lee MK, Park MJ, Kim SJ, Park HJ, Choi JW, Kim SH, Cho SY, Lee JS: Momordin Ic and oleanolic acid from Kochiae Fructus reduce carbon tetrachloride-induced hepatotoxicity in rats. J Med Food. 2005 Summer;8(2):177-83. The CCl4-treated rats had significantly lower activities of glutathione reductase, glutathione S-transferase, superoxide dismutase, catalase, and peroxidase. |
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| 19292473 | Kujawska M, Ignatowicz E, Murias M, Ewertowska M, Mikolajczyk K, Jodynis-Liebert J: Protective effect of red beetroot against carbon tetrachloride- and N-nitrosodiethylamine-induced oxidative stress in rats. J Pineal Res. 2007 Oct;43(3):305-12. Superoxide dismutase activity was increased about 3-fold in animals pretreated with juice. |
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| 19323752 | Kim DH, Song SB, Kang WS, Jeong YH, Yoon YS, Lee YM, Chang BS, Lee KJ: Superfine saengshik improves liver protecting effect compared with fine saengshik in an animal model. World J Gastroenterol. 2005 Mar 28;11(12):1764-8. On the examination of antioxidant effect, water extract of SS showed a higher superoxide dismutase (SOD)-like activity on the condition of the HX/XOD system than that of FS (P < 0.001). |
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| 18761048 | Hsu YW, Tsai CF, Chang WH, Ho YC, Chen WK, Lu FJ: Protective effects of Dunaliella salina--a carotenoids-rich alga, against carbon tetrachloride-induced hepatotoxicity in mice. Arch Pharm Res. 2005 Jul;28(7):791-8. CCl (4) induced liver damage and significantly (p <0.05) increased the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) in serum and decreased the activities of superoxide dismutase (SOD), catalase, peroxidase (GSH-Px), and GSH content in liver whereas increased hepatic malondialdehyde (MDA) content as compared with control group. |
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| 17355462 | Naik SR, Panda VS: Antioxidant and hepatoprotective effects of Ginkgo biloba phytosomes in carbon tetrachloride-induced liver injury in rodents. Zhonghua Gan Zang Bing Za Zhi. 2005 Dec;13(12):903-7. Further, the effects of GBP on lipid peroxidation (LPO), (GSH), superoxide dismutase (SOD), catalase (CAT), peroxidase (GPX) and glutathione reductase (GR) were estimated in liver homogenates to evaluate antioxidant activity. |
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| 15683547 | Tirkey N, Pilkhwal S, Kuhad A, Chopra K: a citrus decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney. J Bras Pneumol. 2008 Jul;34(7):445-52. Oxidative stress in liver and kidney tissue was estimated using Thiobarbituric acid reactive substances (TBARS), (GSH) content, superoxide dismutase (SOD), and Catalase (CAT) RESULTS: CCl4 caused a marked rise in serum levels of ALT and AST (P < 0.05). |
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| 19540299 | Akowuah GA, Zhari I, Mariam A, Yam MF: Absorption of andrographolides from Andrographis paniculata and its effect on CCl (4)-induced oxidative stress in rats. Indian J Exp Biol. 2007 Aug;45(8):702-11. Fourteen days oral treatment of rats with the extract (1 g/kg body weight) followed by CCl (4) administration preserved catalase (CAT), and superoxide dismutase (SOD) activities in erythrocytes, whereas plasma lipid peroxidation, transaminase (ALT) and transaminase (AST) activities were restored to values comparable with control values. |
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| 18306454 | Lee SH, Heo SI, Li L, Lee MJ, Wang MH: Antioxidant and hepatoprotective activities of Cirsium setidens Nakai against CCl4-induced liver damage. Pathophysiology. 2007 Oct;14(2):71-8. Epub 2007 Jul 3. The n-BuOH fraction reduced CCl (4)-induced liver injury in rats, and transcript levels of genes encoding antioxidant enzymes such as glutathione peroxidase 1 (GPO1), glutathione peroxidase 3 (GPO3) and superoxide dismutase (SOD1) were elevated in the livers of rats treated with this fraction (500 mg/kg). |
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| 20141739 | Shen DZ, Tao Q, DU JX, Ding SD, Chen GF, Hu YY, Liu P: [Effects of Yiguanjian Decoction on liver cirrhosis formation:a differential proteomics study in rats.]. Zhong Xi Yi Jie He Xue Bao. 2010 Feb;8(2):158-67. Rat cirrhosis model was established by intraperitoneal injection of 50% carbon tetrachloride (CCl4) plus olive oil solution (1 mL/kg, twice weekly for 9 weeks). Protein expressions of Cu/Zn superoxide dismutase (Cu/Zn SOD) and DJ-1 were validated by Western blot and immunohistochemical methods. |
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| 16676162 | Young SC, Wang CJ, Lin JJ, Peng PL, Hsu JL, Chou FP: Protection effect of piper betel leaf extract against carbon tetrachloride-induced liver fibrosis in rats. Am J Chin Med. 2007;35(6):995-1009. It also attenuated total glutathione S-transferase (GST) activity and GST alpha isoform activity, and on the other hand, enhanced superoxide dismutase (SOD) and catalase (CAT) activities. |
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| 15943754 | Kamalakkannan N, Rukkumani R, Varma PS, Viswanathan P, Rajasekharan KN, Menon VP: Comparative effects of and an analogue of in carbon tetrachloride-induced hepatotoxicity in rats. World J Gastroenterol. 2006 Jul 7;12(25):4052-5. There was a significant (P <0.05) increase in the levels of TBARS and hydroperoxides in liver and kidney and a significant (P <0.05) decrease in the activities of enzymic antioxidants- superoxide dismutase (SOD), catalase and GSH peroxidase along with GSH in CCl (4)-treated rats. |
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| 17637198 | Zhong MM, Chen FH, Yuan LP, Wang XH, Wu FR, Yuan FL, Cheng WM: Protective effect of total flavonoids from Bidens bipinnata L. against carbon tetrachloride-induced liver injury in mice. J Pharm Pharmacol. 2007 Jul;59(7):1017-25. In addition, TFB markedly inhibited CCl4-induced lipid peroxidation and enhanced the activity of the antioxidant enzymes superoxide dismutase and peroxidase. |
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| 15089041 | Lee JY, Lee SH, Kim HJ, Ha JM, Lee SH, Lee JH, Ha BJ: The preventive inhibition of against the CCl4-induced oxidative stress of subcellular level. Food Chem Toxicol. 2009 Sep;47(9):2321-6. Epub 2009 Jun 18. Our work in this study was made in the microsomal fraction to evaluate the lipid peroxidation by measuring superoxide dismutase (SOD), catalase (CAT), peroxidase (GPx), and malondialdehyde (MDA) and to elucidate the preventive role of CS in the CCl4-induced oxidative stress. |
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| 17611085 | Manna P, Sinha M, Sil PC: Phytomedicinal activity of Terminalia arjuna against carbon tetrachloride induced cardiac oxidative stress. Chem Biol Interact. 2004 Jul 20;148(3):125-38. Oral administration of CCl (4) at a dose of 1ml/kg body weight for 2 days significantly reduced the activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST), as well as depleted the level of (GSH) in the cardiac tissue. |
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| 17202657 | Wang CY, Ma FL, Liu JT, Tian JW, Fu FH: Protective effect of salvianic acid a on acute liver injury induced by carbon tetrachloride in rats. Arch Toxicol. 2007 Jan;81(1):45-55. Epub 2006 May 5. Spectrophotometrical method was used to measure activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum, activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (GPx) as well as malondialdehyde (MDA) level in hepatic tissue and the rate of (O2*-) generation in hepatic submitochondrial particles. |
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| 20020986 | Bhattacharjee R, Sil PC: Protein Isolate from the Herb Phyllanthus niruri Modulates Carbon Tetrachloride-Induced Cytotoxicity in Hepatocytes. Life Sci. 2005 Feb 4;76(12):1381-90. Epub 2005 Jan 18. Administration of CCl (4) increased the leakage of glutamate pyruvate transaminase (GPT) by four fold and lactate dehydrogenase (LDH) by 84% in cell suspension, along with increased lipid peroxidation (114%), and reduced the levels of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) to almost 30% and 37% of the normal values, respectively. |
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| 18036097 | Venugopal SK, Wu J, Catana AM, Eisenbud L, He SQ, Duan YY, Follenzi A, Zern MA: Lentivirus-mediated dismutase1 gene delivery protects against oxidative stress-induced liver injury in mice. Liver Int. 2007 Dec;27(10):1311-22. The aim of this present study is to investigate the protective effects of lentiviral vector-mediated -zinc superoxide dismutase (LV-SOD1) gene transfer against ROS-induced cytotoxicity in Hep G2 cells and liver injury in mice. METHODS: In vitro SOD1 efficacy was tested against two ROS-generating systems: /xanthine oxidase (HX/XO) and hydroxyethyl radicals (HER), whereas in vivo SOD1 efficacy was evaluated in carbon tetrachloride (CCl4)-induced liver injury in C57BL/6 mice. |
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| 16437743 | Liu SQ, Yu JP, Chen HL, Luo HS, Chen SM, Yu HG: Therapeutic effects and molecular mechanisms of Ginkgo biloba extract on liver fibrosis in rats. Basic Clin Pharmacol Toxicol. 2005 Jul;97(1):15-21. Rat liver fibrosis was induced by intraperitoneal injection of carbon tetrachloride (CCl4) twice a week for 8 weeks. The activities of superoxide dismutase (SOD) and peroxidase (GSH-Px) were notably elevated, while malondialdehyde (MDA) content was significantly decreased in the rats treated with CCl4 + EGB (p < 0.01 or p < 0.05). |
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| 18812033 | Yuan LP, Chen FH, Ling L, Bo H, Chen ZW, Li F, Zhong MM, Xia LJ: Protective effects of total flavonoids of Bidens bipinnata L. against carbon tetrachloride-induced liver fibrosis in rats. J Med Food. 2009 Oct;12(5):1111-8. In addition, TFB markedly inhibited CCl4-induced lipid peroxidation and enhanced the activity of the antioxidant enzymes superoxide dismutase and peroxidase. |
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| 15489557 | Shahjahan M, Sabitha KE, Jainu M, Shyamala Devi CS: Effect of Solanum trilobatum against carbon tetrachloride induced hepatic damage in albino rats. Int J Pharm. 2007 Feb 7;330(1-2):155-63. Epub 2006 Sep 23. Lipid peroxidation (LP) was increased significant in liver tissue in the CCl4 treated rats (group II) while the activities of peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) were decreased. |
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| 17706384 | Padhy BM, Srivastava A, Kumar VL: Calotropis procera latex affords protection against carbon tetrachloride induced hepatotoxicity in rats. J Agric Food Chem. 2009 Mar 25;57(6):2570-5. Histological analysis of the liver of these rats revealed marked necro-inflammatory changes that were associated with increase in the levels of TBARS, PGE (2) and catalase and decrease in the levels of (GSH), superoxide dismutase (SOD) and peroxidase (GPx). |
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| 18724385 | Campo GM, Avenoso A, Campo S, Nastasi G, Traina P, D'Ascola A, Rugolo CA, Calatroni A: The antioxidant activity of -4-sulphate, in carbon tetrachloride-induced acute hepatitis in mice, involves NF-kappaB and caspase activation. Br J Pharmacol. 2008 Nov;155(6):945-56. Epub 2008 Aug 25. KEY RESULTS: CCl4 injection produced: marked elevation of alanine aminotransferase and aspartate aminotransferase; hepatic membrane lipid peroxidation, assayed by levels; and depletion of and superoxide dismutase. |
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| 19761824 | Wang L, Cheng D, Wang H, Di L, Zhou X, Xu T, Yang X, Liu Y: The hepatoprotective and antifibrotic effects of Saururus chinensis against carbon tetrachloride induced hepatic fibrosis in rats. J Basic Clin Physiol Pharmacol. 2005;16(4):245-56. Evaluated with liver index, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), (HA), hepatic malondialdehyde (MDA) content, and superoxide dismutase (SOD) activity, total (TC), triglyceride (TG), total lipoprotein (TP), albumin (ALB), (HYP), total antioxidant capacity (T-AOC), laminin (LN), type III collagen terminal peptide (PC-IIINP), and type IV collagen (IV-C), as well as with histopathologic changes of liver. |
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| 20082249 | Chen Y, Chen Q, Lu J, Li FH, Tao YY, Liu CH: Effects of Danggui Buxue Decoction () on lipid peroxidation and MMP-2/9 activities of fibrotic liver in rats. Chin J Integr Med. 2009 Dec;15(6):435-41. Epub 2010 Jan 18. METHODS: The liver fifibrosis in 28 rats was induced by an injection of carbon tetrachloride (CCl (4)) and fed with high lipid and low protein diet for 6 weeks, the model rats were randomly divided into the model group and DBD treated group, 14 in each group, and another 10 rats as the normal group were observed as well. The liver function including serum aminotransamine (ALT), transamine (AST), albumin (Alb) and total (TBIL), liver triglyceride (TG) and malondialdehyde (MDA) contents, superoxide dismutase (SOD) activity were assayed. |
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| 18706249 | Dang SS, Zhang X, Jia XL, Cheng YA, Song P, Liu EQ, He Q, Li ZF: Protective effects of emodin and astragalus polysaccharides on chronic hepatic injury in rats. J Food Sci. 2009 Mar;74(2):H59-64. METHODS: Chronic hepatic injury was induced by hypodermic injection of an olive oil solution containing 40% carbon tetrachloride (CCl (4)) twice a week, in addition to a diet of 79.5% maizena, 20% fat, 0.5% and 10% in the drinking water ad libitum for 12 weeks. Liver and spleen indexes were assayed, followed by the measurements of the liver associated enzyme superoxide dismutase (SOD) and malondialdehyde (MDA). |
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| 18652820 | Salazar-Montes A, Ruiz-Corro L, Lopez-Reyes A, Castrejon-Gomez E, Armendariz-Borunda J: Potent antioxidant role of pirfenidone in experimental cirrhosis. . Eur J Pharmacol. 2008 Oct 24;595(1-3):69-77. Epub 2008 Jul 9. Cirrhosis was induced in rats by ligation of the common bile duct or carbon tetrachloride (CCl (4)) chronic intoxication and treated with pirfenidone or diphenyleneiodonium (a potent known antioxidant) for the last two weeks for bile duct ligation model or for the last three weeks for CCl (4) chronic intoxication. Superoxide dismutase (SOD), catalase (CAT) and inducible synthase (iNOS) gene expression were importantly down-regulated where nuclear factor kappa B (NF-kappaB) binding activity also decreased with pirfenidone treatment. |
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| 17965434 | Xu H, Guo T, Guo YF, Zhang J, Li Y, Feng W, Jiao B: Characterization and protection on acute liver injury of a polysaccharide MP-I from Mytilus coruscus. J Pharm Pharmacol. 2008 Oct;60(10):1393-402. MP-I was subjected to investigate the protective effect on carbon tetrachloride (CCl (4)) induced liver damage in male Kunming mice. Pharmacological studies revealed that MP-I could decrease serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), and hepatic malondialdehyde aldehydes (MDA) levels, increase the hepatic total superoxide dismutase (T-SOD) activity, and improve hepatic damage in the CCl (4) induced liver injury in mice in a dose-dependent manner. |
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| 17507320 | Panovska TK, Kulevanova S, Gjorgoski I, Bogdanova M, Petrushevska G: Hepatoprotective effect of the ethyl extract of Teucrium polium L. against carbontetrachloride-induced hepatic injury in rats. Indian J Med Res. 2004 Sep;120(3):194-8. Specific biochemical parameters peroxidase, superoxide dismutase, and total antioxidative status) were estimated in blood and in liver homogenate. |
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| 18361748 | Dani C, Oliboni LS, Pasquali MA, Oliveira MR, Umezu FM, Salvador M, Moreira JC, Henriques JA: Intake of purple grape juice as a hepatoprotective agent in Wistar rats. Am J Chin Med. 2008;36(1):107-14. After 30 days, all animals were sacrificed, and blood and liver were collected to evaluate lipid peroxidation level (thiobarbituric acid-reactive substances [TBARS] assay), protein oxidative level (carbonyl assay), and catalase (CAT) and superoxide dismutase (SOD) activities. |
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| 16097051 | Dai K, Qi JY, Tian DY: Leptin administration exacerbates thioacetamide-induced liver fibrosis in mice. Arch Pharm Res. 2004 Mar;27(3):340-5. The changes in biochemical markers, such as the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and superoxide dismutase (SOD), malondialdehyde (MDA) in liver were determined. |
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| 18979496 | Chang CY, Chen YL, Yang SC, Huang GC, Tsi D, Huang CC, Chen JR, Li JS: Effect of schisandrin B and sesamin mixture on CCl (4)-induced hepatic oxidative stress in rats. J Ethnopharmacol. 2009 Dec 10;126(3):487-91. Epub 2009 Sep 15. To study the effects of schisandrin B and sesamin mixture on carbon tetrachloride (CCl (4))-induced hepatic oxidative stress in male Sprague-Dawley rats. The hepatic superoxide dismutase and peroxidase activities of rats in the low dose and high dose groups were increased significantly compared with those in the CCl (4) group. |
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| 16831245 | Wen T, Ren F, Liu Y, Wu ZM, Zhao JY: [Expression of Fas antigen and Fas ligand in acute liver injury induced by carbon tetrachloride in rat]. Food Chem Toxicol. 2009 Jun;47(6):1393-9. Epub 2009 Mar 25. Superoxide dismutase (SOD) activity and malondialdehyde (MDA) concentration in the liver tissues were analyzed at the same time point. |
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| 20119817 | Shaker ME, Houssen ME, Abo-Hashem EM, Ibrahim TM: Comparison of and in ameliorating carbon tetrachloride and diabetes induced hepatic oxidative stress. Toxicol Mech Methods. 2007;17(1):41-7. Thereafter, changes in serum level, liver function tests, hepatic malondialdehyde (MDA) content, hepatic (GSH) content, hepatic superoxide dismutase (SOD) activity, and serum total antioxidant capacity (TAC) level were evaluated. |
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| 17010209 | Manna P, Sinha M, Sil PC: Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders. Basic Clin Pharmacol Toxicol. 2007 Feb;100(2):115-20. Antioxidant status in both the liver and kidney tissues were estimated by determining the activities of the antioxidative enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST); as well as by determining the levels of thiobarbutaric acid reactive substances (TBARS) and reduced glutathione (GSH). |
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| 18160022 | Chiu PY, Leung HY, Siu AH, Chen N, Poon MK, Ko KM: Long-term treatment with a Yang-invigorating Chinese herbal formula produces generalized tissue protection against oxidative damage in rats. Am J Chin Med. 2006;34(1):99-114. Interestingly, the VI-28 treatment increased red cell CuZn-superoxide dismutase (CuZn-SOD) levels, and these levels correlated positively with the degree of tissue protection afforded by long-term VI-28 treatment in rats. |
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| 18476390 | Anilakumar KR, Krishna KR, Chandramohan G, Khanum F, Bawa AS: Bees wax polyphenols as suppressor of CC1--induced oxidative stress in rats. BMC Pharmacol. 2005 Jan 31;5:2. As the polyphenols are thought to protect cell constituents against oxidative damage through scavenging of free radicals, the present work was undertaken to evaluate the effects of polyphenols extracted from bees wax on the oxidative stress induced by carbon tetrachloride (CCl4) in rats. The results showed a significant decrease in hepatic antioxidant enzyme activities viz. catalase, glucose-6-phosphate dehydrogenase (G-6-PDH), peroxidase (GSH-Px), glutathione reductase, superoxide dismutase (SOD) and a significant increase in glutathione S-transferase (GST) and gamma-glutamyl transpeptidase (GGT) by CCl4, probably due to the peroxidative effects. |
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