| Name | demethylase |
|---|---|
| Synonyms | DMTase; Demethylase; MBD 2; MBD2; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; NY CO 41; Demethylases… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19595748 | Chan WH, Liao JW, Chou CP, Chan PK, Wei CF, Ueng TH: Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol. Toxicol Lett. 2009 Oct 28;190(2):150-5. Epub 2009 Jul 10. Treatments with 10 and 25mg/kg dicofol produced dose-related increases of cytochrome P450 and cytochrome b (5) contents and -cytochrome c reductase, 7-ethoxyresorufin O-deethylase, pentoxyresorufin O-dealkylase, hydroxylase, and erythromycin N-demethylase activities in liver microsomes. |
1(0,0,0,1) | Details |
| 17877147 | Kujawska M, Jodynis-Liebert J, Ewertowska M, Adamska T, Matlawska I, Bylka W: Protective effect of Aquilegia vulgaris (L.) on carbon tetrachloride-induced oxidative stress in rats. Indian J Exp Biol. 2007 Aug;45(8):702-11. |
0(0,0,0,0) | Details |
| 17610925 | Kim YC, Yim HK, Jung YS, Park JH, Kim SY: Hepatic injury induces contrasting response in liver and kidney to chemicals that are metabolically activated: role of male sex hormone. Toxicol Appl Pharmacol. 2007 Aug 15;223(1):56-65. Epub 2007 May 24. Carbon tetrachloride pretreatment or partial hepatectomy decreased the hepatic xenobiotic-metabolizing enzyme activities in both sexes but elevated the renal hydroxylase, p-nitroanisole O-demethylase and aminopyrine N-demethylase activities significantly only in male mice. |
81(1,1,1,1) | Details |
| 16117609 | Kim NY, Lee MK, Park MJ, Kim SJ, Park HJ, Choi JW, Kim SH, Cho SY, Lee JS: Momordin Ic and oleanolic acid from Kochiae Fructus reduce carbon tetrachloride-induced hepatotoxicity in rats. J Med Food. 2005 Summer;8(2):177-83. Pretreatment with momordin Ic and oleanolic acid resulted in significantly lower production of aminopyrine N-demethylase and hydroxylase in the CCl4-treated rats. |
2(0,0,0,2) | Details |
| 18639619 | Chandan BK, Saxena AK, Shukla S, Sharma N, Gupta DK, Singh K, Suri J, Bhadauria M, Qazi GN: Hepatoprotective activity of Woodfordia fruticosa Kurz flowers against carbon tetrachloride induced hepatotoxicity. J Ethnopharmacol. 2008 Sep 26;119(2):218-24. Epub 2008 Jun 28. The restoration of microsomal hydroxylase and amidopyrine-N-demethylase activities indicated the improvement in functional status of endoplasmic reticulum. |
1(0,0,0,1) | Details |
| 17973928 | Chen M, Xu D, Hu XL, Wang H: Effects of liver fibrosis on pharmacokinetics in rats. Clin Exp Pharmacol Physiol. 2008 Mar;35(3):287-94. Epub 2007 Oct 31. A rat liver fibrosis model was successfully established using several inducers, including a high-fat diet, and carbon tetrachloride. The activity of hepatic and small intestinal microsomal erythromycin N-demethylase (a marker for CYP3A) and the expression of small intestinal cyp3a and multidrug resistance (mdr) mRNA were compared between normal rats and rats with liver fibrosis. 3. |
1(0,0,0,1) | Details |
| 17410408 | Bhadauria M, Nirala SK, Shukla S: Propolis protects CYP 2E1 enzymatic activity and oxidative stress induced by carbon tetrachloride. Mol Cell Biochem. 2007 Aug;302(1-2):215-24. Epub 2007 Apr 5. Hepatic microsomal drug metabolizing enzymes of CYP 2E1 showed sharp depletion as assessed by estimating hydroxylase and amidopyrine N-demethylase activity after CCl (4) exposure. |
1(0,0,0,1) | Details |
| 16182555 | Wang H, Liao ZX, Chen M, Hu XL: Effects of hepatic fibrosis on ofloxacin pharmacokinetics in rats. Pharmacol Res. 2006 Jan;53(1):28-34. Epub 2005 Sep 21. Furthermore, the increases in the levels of microsomal ethoxyresorufin O-deethylase and erythromycin N-demethylase were accompanied with up-regulation of mdr 1a mRNA in the small intestines of hepatic fibrosis rats when compared to those of the normal rats. Rat hepatic fibrosis model was successfully induced using complex factors including carbon tetrachloride, and high fat. |
1(0,0,0,1) | Details |
| 19067753 | Bhadauria M, Nirala SK, Shrivastava S, Sharma A, Johri S, Chandan BK, Singh B, Saxena AK, Shukla S: Emodin reverses CCl induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural changes: The in vivo evidence. Hepatol Res. 2009 Mar;39(3):290-300. Epub 2008 Dec 2. Aim: The curative effect of emodin (1,3,8-trihydroxy-6-methyl anthraquinone), an active compound of the plant species Ventilago maderaspatana Gaertn, was evaluated against carbon tetrachloride (CCl (4)) induced hepatic cytochrome P450 (CYP) enzymatic and ultrastructural alterations in rats. Exposure to CCl (4) diminished the activities of CYP enzymes (i.e. hydroxylase and amidopyrine-N-demethylase and microsomal protein contents with concomitant increase in microsomal lipid peroxidation). |
1(0,0,0,1) | Details |
| 16445600 | Yim HK, Jung YS, Kim SY, Kim YC: Contrasting changes in phase I and phase II metabolism of in male mice pretreated with carbon tetrachloride. Basic Clin Pharmacol Toxicol. 2006 Feb;98(2):225-30. Likewise, CCl (4) treatment reduced the microsomal hydroxylase and p-nitroanisole O-demethylase activities to less than one third of control. |
1(0,0,0,1) | Details |
| 17177172 | Kim SJ, Jung YS, Yoon MY, Kim YC: Comparative effects of dimethylsulfoxide on metabolism and toxicity of carbon tetrachloride and dichloromethane. J Appl Toxicol. 2007 Jan-Feb;27(1):25-31. DMSO induced the microsomal hydroxylase and p-nitroanisole O-demethylase activities as early as 2 h following the treatment. |
1(0,0,0,1) | Details |
| 18572298 | Bhadauria M, Nirala SK, Shukla S: Multiple treatment of propolis extract ameliorates carbon tetrachloride induced liver injury in rats. Food Chem Toxicol. 2008 Aug;46(8):2703-12. Epub 2008 Apr 27. Multiple treatment of propolis significantly prevented the release of transaminases, alkaline phosphatase, lactate dehydrogenase, gamma-glutamyl transpeptidase, urea and in serum; improved the activity of hepatic microsomal drug metabolizing enzymes, i.e., hydroxylase and amidopyrine-N-demethylase; significantly inhibited lipid peroxidation and markedly enhanced in liver and kidney as well as brought altered carbohydrate contents (blood sugar and tissue protein contents (serum, microsomal and tissue protein) and lipid contents (serum and tissue triglycerides, serum cholesterol, total and esterified in tissue) towards control. |
1(0,0,0,1) | Details |
| 17291700 | Chandan BK, Saxena AK, Shukla S, Sharma N, Gupta DK, Suri KA, Suri J, Bhadauria M, Singh B: Hepatoprotective potential of Aloe barbadensis Mill. against carbon tetrachloride induced hepatotoxicity. J Ethnopharmacol. 2007 May 22;111(3):560-6. Epub 2007 Jan 14. Hepatoprotective potential was confirmed by the restoration of lipid peroxidation, glucose-6-phosphatase and microsomal hydroxylase and amidopyrine N-demethylase towards near normal. |
1(0,0,0,1) | Details |