Protein Information

Name aryl hydrocarbon receptor
Synonyms AHR; Ah receptor; AhR; Aryl hydrocarbon receptor; Aryl hydrocarbon receptor precursor; Dioxin receptor; Ah receptors; AhRs…

Compound Information

Name endrin
CAS

Reference List

PubMed Abstract RScore(About this table)
8697196 Hassoun EA, Stohs SJ: Comparative teratological studies on TCDD, endrin and lindane in C57BL/6J and DBA/2J mice. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1996 Mar;113(3):393-8.

The results support the hypothesis that TCDD-induced cleft plate and hydronephrosis involve mechanisms that are Ah (aryl hydrocarbon) receptor mediated.
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8983165 Hassoun EA, Stohs SJ: TCDD, endrin and lindane induced oxidative stress in fetal and placental tissues of C57BL/6J and DBA/2J mice. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1996 Sep;115(1):11-8.

The results suggest that superoxide production, lipid peroxidation and DNA-SSB in fetal and placental tissues may participate in the fetotoxic effects of TCDD and other polyhalogenated cyclic hydrocarbons, and that TCDD-induced oxidative damage in fetal and placental tissues is mediated at least in part by the Ah-receptor.
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7900971 Bagchi M, Hassoun E, Akubue P, Bagchi D, Stohs SJ: Comparative effects of endrin on hepatic lipid peroxidation and DNA damage, and nitric oxide production by peritoneal macrophages from C57BL/6J and DBA/2 mice. Comp Biochem Physiol C. 1993 Jul;105(3):525-9.

In order to further assess the mechanism of toxicity of endrin, the dose-dependent effects of endrin on hepatic lipid peroxidation and DNA damage, and nitric oxide (NO) production by peritoneal exudate cells (primarily macrophages) were investigated in C57BL/6J and DBA/2 mice which vary at the Ah receptor genetic locus.
81(1,1,1,1) Details
18767702 Lam JC, Murphy MB, Wang Y, Tanabe S, Giesy JP, Lam PK: Risk assessment of organohalogenated compounds in water bird eggs from South China. Environ Sci Technol. 2008 Aug 15;42(16):6296-302.

Organohalogen compounds, the pesticides aldrin, dieldrin, endrin, hexachlorobenzene, mirex, Sigmachlordanes, SigmaDDTs, Sigmaheptachlors, Sigmatoxaphenes, and the industrial chemicals SigmaPCBs and SigmaPBDEs, as well as total dioxin-like equivalents (TEQH4IIE-luc), were measured in eggs of two Ardeid species, the little egret (Egretta garzetta) and black-crowned night heron (Nycticorax nycticorax) from three port cities along the South China coast: Hong Kong, Xiamen, and Quanzhou.
Total concentrations of dioxin-like PCBtoxic equivalents (TEQs), measured as the aryl hydrocarbon receptor (AhR)-mediated responses of the H4IIE-luc bioassay (TEQH4IIE-luc), were greatest in Hong Kong samples.
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