Protein Information

Name CD34
Synonyms CD34; CD34 antigen; CD34 molecule; CD34F; HPCA 1; HPCA1; Hematopoietic progenitor cell antigen; Hematopoietic progenitor cell antigen CD34…

Compound Information

Name carbon tetrachloride
CAS tetrachloromethane

Reference List

PubMed Abstract RScore(About this table)
18042797 Miyata E, Masuya M, Yoshida S, Nakamura S, Kato K, Sugimoto Y, Shibasaki T, Yamamura K, Ohishi K, Nishii K, Ishikawa F, Shiku H, Katayama N: Hematopoietic origin of hepatic stellate cells in the adult liver. . Blood. 2008 Feb 15;111(4):2427-35. Epub 2007 Nov 27.

To test this hypothesis, we generated chimeric mice by transplantation of clonal populations of cells derived from single enhanced green fluorescent protein (EGFP)-marked Lin (-) Sca-1 (+) c-kit (+) CD34 (-) cells and examined the histology of liver tissues obtained from the chimeric mice with carbon tetrachloride (CCl (4))-induced injury.
6(0,0,1,1) Details
19957847 Yan L, Cai H, Chen Y, Tan W: [Effect of hepatocyte-like cells induced by CD34+ cells in vitro on the repair of injured hepatic tissues of mice in vivo]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Oct;23(10):1235-40.

Forty-eight 6-week-old female ICR mice were chosen to prepare liver injury model by injecting carbon tetrachloride and 2-acetylamionoflu-orene.
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16964416 Qian H, Wang J, Wang S, Gong Z, Chen M, Ren Z, Huang S: In utero transplantation of human hematopoietic stem/progenitor cells partially repairs injured liver in mice. Int J Mol Med. 2006 Oct;18(4):633-42.

The aim of this study is to establish a novel mouse model with high achievement and chimerism by in utero transplantation of human hematopoietic stem/progenitor cells and to explore the possibility that human adult hematopoietic stem/progenitor cells can differentiate into hepatocyte-like cells and partially repair the liver damage induced by carbon tetrachloride (CCl (4)).
Mononuclear cells (MNCs) were isolated from fresh human umbilical cord blood (hUCB) and CD34 (+) cells were enriched from the MNCs by magnetic cell isolation.
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18071240 Ito Y, Watanabe T, Nagatomo S, Seki T, Niimi S, Ariga T: Annexin A3-expressing cellular phenotypes emerge from necrotic lesion in the pericentral area in 2-acetylaminofluoren/carbon tetrachloride-treated rat livers. Biosci Biotechnol Biochem. 2007 Dec;71(12):3082-9. Epub 2007 Dec 7.

These albumin-expressed cells were histologically similar to cells expressing CD34, a hematopoietic cell marker protein.
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16109558 Xiang GA, Zhang GQ, Fang CH, Gao P, Chen KY: [A preliminary study of the homing capacity of allograft mesenchymal stem cells to rat liver]. Di Yi Jun Yi Da Xue Xue Bao. 2005 Aug;25(8):994-7.

The MSCs were identified by the monoclonal antibodies of CD29, CD44, CD34, CD45, CD90, SH-2 and SH-3 followed by transfection with a GFP retroviral vector.
After ex vivo expansion, the transfected MSCs were infused through the tail vein or portal veins of rats, some of which were subjected to treatment with carbon tetrachloride (CCl (4)) to induce centrolobular liver necrosis.
1(0,0,0,1) Details
19141029 Yan Y, Xu W, Qian H, Si Y, Zhu W, Cao H, Zhou H, Mao F: Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injury in vivo. Liver Int. 2009 Mar;29(3):356-65. Epub 2008 Dec 29.


METHODS: Human umbilical cord-derived mesenchymal stem cells, characterized by flow cytometry, were transplanted into carbon tetrachloride (CCl (4))-injured mice, and then followed for determination of localization and differentiation.
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