| Name | CD8 |
|---|---|
| Synonyms | CD8; p32; MAL; CD8A; CD8a antigen; CD8a molecule; LEU2 T lymphocyte antigen; Leu2… |
| Name | carbon tetrachloride |
|---|---|
| CAS | tetrachloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15362042 | Safadi R, Ohta M, Alvarez CE, Fiel MI, Bansal M, Mehal WZ, Friedman SL: Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes. Gastroenterology. 2004 Sep;127(3):870-82. METHODS: We generated transgenic (TG) mice with hepatocyte expression of rat IL-10 (rIL-10) to assess its impact on lymphocyte subsets and activation of hepatic stellate cells following liver injury from carbon tetrachloride (CCl 4 ) or thioacetamide (TAA). |
5(0,0,0,5) | Details |
| 17698563 | Safadi R, Zigmond E, Pappo O, Shalev Z, Ilan Y: Amelioration of hepatic fibrosis via beta--mediated immune modulation is associated with altered CD8 and NKT lymphocyte distribution. Int Immunol. 2007 Aug;19(8):1021-9. Epub 2007 Aug 13. METHODS: Hepatic fibrosis was induced by biweekly intra-peritoneal (IP) carbon tetrachloride (CCl (4)) administrations for 7 weeks in 5 groups (A-E) of male C57Bl/6 mice. |
4(0,0,0,4) | Details |
| 18361832 | Li J, Cheng LF, Li Z, Cong YW: [Intestinal intraepithelial lymphocytes in cirrhosis: experiment with rats]. Zhonghua Yi Xue Za Zhi. 2008 Jan 22;88(4):233-5. METHODS: Forty Wistar rats were randomly divided into 2 groups: cirrhosis group (n = 25) undergoing subcutaneous injection of 40% carbon tetrachloride twice a week for 10-12 weeks to establish cirrhosis models, and control group (n = 15). The T lymphocytes in the intestinal epithelium were isolated and labeled with mouse anti-rat CD3, CD4 and CD8 monoclonal antibody, Flow cytometry was performed. |
4(0,0,0,4) | Details |
| 17437422 | Muhanna N, Horani A, Doron S, Safadi R: Lymphocyte-hepatic stellate cell proximity suggests a direct interaction. . Clin Exp Immunol. 2007 May;148(2):338-47. Recent functional research studies suggest an anti-fibrotic role for natural killer (NK) cells coupled with a profibrotic role for CD8 cells. To investigate lymphocyte/hepatic stellate cell (HSC) interactions, hepatic fibrosis was induced by administering carbon tetrachloride (CCl4) intraperitoneally (i.p.) for 4 weeks in C57Bl/6 mice. |
3(0,0,0,3) | Details |
| 17038628 | Horani A, Muhanna N, Pappo O, Melhem A, Alvarez CE, Doron S, Wehbi W, Dimitrios K, Friedman SL, Safadi R: Beneficial effect of glatiramer acetate (Copaxone) on immune modulation of experimental hepatic fibrosis. Am J Physiol Gastrointest Liver Physiol. 2007 Feb;292(2):G628-38. Epub 2006 Oct 12. While CD8 subsets activate hepatic fibrosis, natural killer (NK) cells exhibit antifibrotic activity. Hepatic fibrosis was induced in C57BL/6 mice by intraperitoneal administration of carbon tetrachloride (CCl (4)) for 6 wk. |
3(0,0,0,3) | Details |
| 18279442 | Higazi AA, El-Haj M, Melhem A, Horani A, Pappo O, Alvarez CE, Muhanna N, Friedman SL, Safadi R: Immunomodulatory effects of plasminogen activators on hepatic fibrogenesis. Clin Exp Immunol. 2008 Apr;152(1):163-73. Epub 2008 Feb 14. We examined the potential immunomodulatory actions of uPA, tPA and uPA-receptor (uPAR) in carbon-tetrachloride-induced hepatic fibrosis in wild-type (WT), tPA-/-, uPA-/- and uPAR-/- mice. Following uPA exposure in vivo, there was CD8 predominance. |
2(0,0,0,2) | Details |
| 19659781 | Ginsburg I, Koren E, Horani A, Mahamid M, Doron S, Muhanna N, Amer J, Safadi R: Amelioration of hepatic fibrosis via Padma Hepaten is associated with altered natural killer T lymphocytes. Clin Exp Immunol. 2009 Jul;157(1):155-64. Unlike the anti-fibrotic effect of natural killer (NK) cells, CD8 and NK T subsets are considered as profibrogenic subsets. Hepatic fibrosis was induced by 6 weeks of biweekly i.p. carbon tetrachloride (CCl4) injections in male C57Bl6 mice. |
1(0,0,0,1) | Details |
| 19205035 | Park O, Jeong WI, Wang L, Wang H, Lian ZX, Gershwin ME, Gao B: Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride. Hepatology. 2009 May;49(5):1683-94. Although a variety of cell populations infiltrate the liver during inflammation, it is generically clear that CD8 T lymphocytes promote while natural killer (NK) cells inhibit liver fibrosis. |
1(0,0,0,1) | Details |