| Name | glutathione reductase |
|---|---|
| Synonyms | GLUR; GR; GRD 1; GRD1; GRase; GSR; Glutathione reductase; GRases… |
| Name | lindane |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10817630 | Videla LA, Arisi AC, Fuzaro AP, Koch OR, Junqueira VB: Prolonged phenobarbital pretreatment abolishes the early oxidative stress component induced in the liver by acute lindane intoxication. Toxicol Lett. 2000 Apr 10;115(1):45-51. These changes were observed in the absence of changes in either microsomal functions (cytochrome P450 content, -dependent production, and NADPH-cytochrome P450 reductase or oxidase activities) or in oxidative stress-related enzymatic activities (superoxide dismutase, catalase, peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase, and glutathione-S-transferases), over control values. |
2(0,0,0,2) | Details |
| 8882386 | Descampiaux B, Leroux JM, Peucelle C, Erb F: Assay of free-radical toxicity and antioxidant effect on the Hep 3B cell line: a test survey using lindane. Cell Biol Toxicol. 1996 Feb;12(1):19-28. The content of and of as well as the activities of glutathione reductase, peroxidase, glutathione S-transferases, catalase and superoxide dismutases were determined in human hepatoma Hep 3B cells in relation to free-radical toxicity in order to appreciate the defense capacities of these cells compared to data on normal hepatocytes. |
1(0,0,0,1) | Details |
| 18389491 | Ahmed RS, Suke SG, Seth V, Chakraborti A, Tripathi AK, Banerjee BD: Protective effects of dietary ginger (Zingiber officinales Rosc.) on lindane-induced oxidative stress in rats. Phytother Res. 2008 Jul;22(7):902-6. Concomitant dietary feeding of ginger (1%w/w) significantly attenuated lindane-induced lipid peroxidation, accompanied by modulation of OFR scavenging enzymes as well as (GSH) and the GSH dependent enzymes peroxidase (Gpx), glutathione reductase (GR) and glutathione-S-transferase (GST) in these rats. |
81(1,1,1,1) | Details |
| 7512143 | Junqueira VB, Bainy AC, Arisi AC, Azzalis LA, Simizu K, Pimentel R, Barros SB, Videla LA: Acute lindane intoxication: a study on lindane tissue concentration and oxidative stress-related parameters in liver and erythrocytes. J Biochem Toxicol. 1994 Feb;9(1):9-15. Concomitantly, liver content and the activity of peroxidase-glutathione reductase couple were augmented by lindane treatment, without any change in superoxide dismutase activity, together with a reduction in that of catalase. |
81(1,1,1,1) | Details |
| 7692623 | Junqueira VB, Barros SB, Simizu K, Fernandez V, Carrion Y, Pimentel R, Azzalis LA, Videla LA: Turnover of hepatic after acute lindane intoxication. Toxicol Lett. 1993 Aug;69(2):211-6. At these experimental times, the activities of peroxidase, glutathione reductase, glutathione-S-transferases and gamma-glutamyltransferase in the liver of lindane-treated rats and control animals were comparable. |
6(0,0,1,1) | Details |
| 15620088 | Sheweita SA: Carcinogen-metabolizing enzymes and insecticides. J Environ Sci Health B. 2004;39(5-6):805-18. In addition, the activity of glutathione S-transferase (GST), glutathione reductase (GR), and the level of (GSH) were determined in the liver of male mice after oral administration of sumithion, dursban, chlordane, methoxychlor, heptachlor epoxide, and lindane as single (24h) or as repeated doses for six consecutive days. |
6(0,0,1,1) | Details |
| 11561191 | Chitra KC, Sujatha R, Latchoumycandane C, Mathur PP: Effect of lindane on antioxidant enzymes in epididymis and epididymal sperm of adult rats. Asian J Androl. 2001 Sep;3(3):205-8. Significant decreases in the superoxide dismutase (SOD), catalase, glutathione reductase and peroxidase activities and significant increases in the H2O2 generation and lipid peroxidation were also observed in the epididymis and epididymal sperm of lindane-treated rats. |
6(0,0,1,1) | Details |
| 17761640 | Trivedi NP, Rawal UM, Patel BP: Hepatoprotective effect of andrographolide against hexachlorocyclohexane-induced oxidative injury. Integr Cancer Ther. 2007 Sep;6(3):271-80. (GSH), glutathione-s-transferase (GST), glutathione reductase (GR), peroxidase (GSH-Px), gamma-glutamyl transpeptidase (gamma-GTP), superoxide dismutase (SOD), catalase (CAT), and lipid peroxidation (LPO) are studied by spectrophotometric methods. |
1(0,0,0,1) | Details |
| 11404799 | Sujatha R, Chitra KC, Latchoumycandane C, Mathur PP: Effect of lindane on testicular antioxidant system and steroidogenic enzymes in adult rats. Asian J Androl. 2001 Jun;3(2):135-8. There was a significant decline in the activities of antioxidant enzymes superoxide dismutase (SOD), catalase and glutathione reductase while an increase in peroxide (H2O2) generation was observed. |
1(0,0,0,1) | Details |
| 1708174 | Barros SB, Simizu K, Junqueira VB: Liver lipid peroxidation-related parameters after short-term administration of hexachlorocyclohexane isomers to rats. Toxicol Lett. 1991 Apr;56(1-2):137-44. Other parameters studied were liver glucose-6-phosphate dehydrogenase, peroxidase, glutathione reductase and catalase (CAT) activities. |
1(0,0,0,1) | Details |
| 17123163 | Anilakumar KR, Khanum F, Santhanam K: Amelioration of hexachlorocyclohexane-induced oxidative stress by amaranth leaves in rats. Plant Foods Hum Nutr. 2006 Dec;61(4):169-73. Feeding of AL at 10% level increased the hepatic glucose-6-phosphate dehydrogenase (G-6-PDH) activity while that at 20% level increased the hepatic glutathione reductase (GSSGR) as well, in addition to G-6-PDH. |
1(0,0,0,1) | Details |
| 10350190 | Samanta L, Sahoo A, Chainy GB: Age-related changes in rat testicular oxidative stress parameters by hexachlorocyclohexane. Arch Toxicol. 1999 Mar;73(2):96-107. Testicular peroxidase (GPx; total and non--dependent) activity was enhanced in both the age-groups of rats while the testicular content as well as glutathione reductase activity remained unaltered. |
1(0,0,0,1) | Details |
| 16838206 | Wang F, Xu ZR, Sun JH: Effect of HCH contamination of diet on the growth performance and immune and antioxidant ability in growing/finishing pigs. Vet Res Commun. 2006 Aug;30(6):645-54. Addition of HCH to feedstuff reduced superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR) and peroxidase (GSH-Px) activities in liver, reduced serum catalase (CAT) activity, and increased serum malondialehyde (MDA). |
1(0,0,0,1) | Details |
| 12487730 | Garcia-Fernandez AJ, Bayoumi AE, Perez-Pertejo Y, Romero D, Ordonez C, Reguera RM, Balana-Fouce R, Ordonez D: Changes in -redox balance induced by hexachlorocyclohexane and lindane in CHO-K1 cells. Xenobiotica. 2002 Nov;32(11):1007-16. The -redox cycle enzymes peroxidase, glutathione reductase and glutathione S-transferase, and total and were evaluated at several points during the standard growth curve of the cultures. 2. |
1(0,0,0,1) | Details |
| 16046044 | Srivastava A, Shivanandappa T: Hexachlorocyclohexane differentially alters the antioxidant status of the brain regions in rat. Toxicology. 2005 Oct 15;214(1-2):123-30. Activities of peroxidase, glutathione reductase, glutathione-S-transferase and catalase were markedly induced whereas superoxide dismutase was inhibited at higher dose in all the brain regions. |
1(0,0,0,1) | Details |
| 10790496 | Sahoo A, Samanta L, Chainy GB: Mediation of oxidative stress in HCH-induced neurotoxicity in rat. Arch Environ Contam Toxicol. 2000 Jul;39(1):7-12. Activity of glutathione reductase and content of however, were enhanced following the pesticide exposure. |
1(0,0,0,1) | Details |
| 9704597 | Sahoo A, Chainy GB: Acute hexachlorocyclohexane-induced oxidative stress in rat cerebral hemisphere. Neurochem Res. 1998 Aug;23(8):1079-84. In contrast, glutathione reductase activity was elevated till 24 h after a fall at 6 h of pesticide exposure. |
1(0,0,0,1) | Details |
| 7521977 | Arisi AC, Simizu K, Kogake M, Bainy AC, Silva MA, Barros SB, Boveris A, Videla LA, Junqueira VB: Brain and liver lipid peroxidation levels following acute and short-term lindane administration in the rat. Toxicol Lett. 1994 Oct;74(1):61-8. |
0(0,0,0,0) | Details |
| 11349524 | Trivedi NP, Rawal UM: Hepatoprotective and antioxidant property of Andrographis paniculata (Nees) in BHC induced liver damage in mice. Indian J Exp Biol. 2001 Jan;39(1):41-6. Administration of AP showed protective effects in the activity of superoxide dismutase, catalase, peroxidase, glutathione reductase as well the level of |
1(0,0,0,1) | Details |