| Name | glutathione transferase |
|---|---|
| Synonyms | GST class mu 2; GST 4; GST4; GSTM; GSTM 2; GSTM2; GSTM2 2; GSTmu3… |
| Name | ethylene dibromide |
|---|---|
| CAS | 1,2-dibromoethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16948056 | Josephy PD, Taylor PL, Vervaet G, Mannervik B: Screening and characterization of variant Theta-class glutathione transferases catalyzing the activation of ethylene dibromide to a mutagen. Environ Mol Mutagen. 2006 Dec;47(9):657-65. |
82(1,1,1,2) | Details |
| 1739400 | Lundqvist G, Morgenstern R: Studies on the activation of rat liver microsomal glutathione transferase in isolated hepatocytes. Biochem Pharmacol. 1992 Jan 22;43(2):131-5. |
10(0,0,0,10) | Details |
| 1898041 | Warren DL, Reed DJ: Modification of hepatic stores in vivo. Arch Biochem Biophys. 1991 Aug 1;288(2):449-55. depletion may be dependent upon initial steps of DBE metabolism that are either oxidative (cytochrome P450 dependent) or conjugative (glutathione transferase dependent). |
1(0,0,0,1) | Details |
| 8679012 | Chiarpotto E, Biasi F, Scavazza A, Camandola S, Aragno M, Tamagno E, Danni O, Dianzani MU, Poli G: involvement in -induced potentiation of rat hepatocyte damage due to the carcinogen 1,2-dibromoethane. Alcohol Alcohol. 1995 Nov;30(6):721-8. By pretreatment with 4-methylpyrazole, an inhibitor of formation, the inactivation of glutathione transferase was actually prevented. |
1(0,0,0,1) | Details |
| 7036301 | Shih TW, Hill DL: Metabolic activation of 1,2-dibromoethane by glutathione transferase and by microsomal mixed function oxidase: further evidence for formation of two reactive metabolites. Res Commun Chem Pathol Pharmacol. 1981 Sep;33(3):449-61. |
1(0,0,0,1) | Details |
| 12902151 | Ross MK, Pegram RA: [35S]-labeling of the Salmonella typhimurium pool to assess -mediated DNA binding by 1,2-dibromoethane. Chem Biol Interact. 2003 Jul 25;146(1):39-49. The strain of Salmonella used in this study had been transformed previously with the gene that codes for rat glutathione transferase theta 1-1 (GSTT1-1), an enzyme that can catalyze formation of genotoxic GSH conjugates. |
1(0,0,0,1) | Details |
| 1891769 | Danni O, Chiarpotto E, Aragno M, Biasi F, Comoglio A, Belliardo F, Dianzani MU, Poli G: Lipid peroxidation and irreversible cell damage: synergism between carbon tetrachloride and 1,2-dibromoethane in isolated rat hepatocytes. Toxicol Appl Pharmacol. 1991 Sep 1;110(2):216-22. The increased prooxidant effect of CCl4 plus DBE compared to CCl4 alone seems related to the shift in DBE metabolism consequent to the CCl4-dependent inactivation of glutathione transferase. |
1(0,0,0,1) | Details |
| 7748274 | Chiarpotto E, Biasi F, Aragno M, Scavazza A, Danni O, Dianzani MU, Poli G: -induced potentiation of rat hepatocyte damage due to 1,2-dibromoethane. Alcohol Alcohol. 1995 Jan;30(1):37-45. The potentiation of the DBE effects by may be through a series of mechanisms, such as a strong inactivation of hepatocyte glutathione transferase similar to that caused by CCl4, an increased basal level of lipid peroxidation and a significant loss of total |
1(0,0,0,1) | Details |