Protein Information

Name lysozyme
Synonyms LYZ; LZM; Lysozyme; Lysozyme C; Lysozyme C precursor; Lysozymes; Lysozyme Cs; Lysozyme C precursors

Compound Information

Name ethylene oxide
CAS oxirane

Reference List

PubMed Abstract RScore(About this table)
19637151 Gao G, Yan Y, Pispas S, Yao P: Sustained and extended release with structural and activity recovery of lysozyme from complexes with sodium (sulfamate carboxylate) isoprene/ethylene oxide block copolymer. Macromol Biosci. 2010 Feb 11;10(2):139-46.
169(2,2,2,9) Details
15465306 Almeida NL, Oliveira CL, Torriani IL, Loh W: Calorimetric and structural investigation of the interaction of lysozyme and bovine serum albumin with poly (ethylene oxide) and its copolymers. Colloids Surf B Biointerfaces. 2004 Oct 10;38(1-2):67-76.
112(1,2,2,2) Details
17583920 Danial M, Klok HA, Norde W, Stuart MA: Complex coacervate core micelles with a lysozyme-modified corona. Langmuir. 2007 Jul 17;23(15):8003-9. Epub 2007 Jun 21.

This paper describes the preparation, characterization, and enzymatic activity of complex coacervate core micelles (C3Ms) composed of poly (acrylic acid) (PAA) and poly (N-methyl-2-vinyl pyridinium iodide)-b-poly (ethylene oxide) (PQ2VP-PEO) to which the antibacterial enzyme lysozyme is end-attached.
37(0,1,1,7) Details
18549295 Belegrinou S, Mannelli I, Lisboa P, Bretagnol F, Valsesia A, Ceccone G, Colpo P, Rauscher H, Rossi F: pH-dependent immobilization of proteins on surfaces functionalized by plasma-enhanced chemical vapor deposition of poly (acrylic acid)- and poly (ethylene oxide)-like films. Langmuir. 2008 Jul 15;24(14):7251-61. Epub 2008 Jun 13.

The interaction of the proteins bovine serum albumin (BSA), lysozyme (Lys), lactoferrin (Lf), and fibronectin (Fn) with surfaces of protein-resistant poly (ethylene oxide) (PEO) and protein-adsorbing poly (acrylic acid) (PAA) fabricated by plasma-enhanced chemical vapor deposition has been studied with quartz crystal microbalance with dissipation monitoring (QCM-D).
31(0,1,1,1) Details
17321084 Kim TG, Lee DS, Park TG: Controlled protein release from electrospun biodegradable fiber mesh composed of poly (epsilon-caprolactone) and poly (ethylene oxide). Int J Pharm. 2007 Jun 29;338(1-2):276-83. Epub 2007 Feb 2.

Various biodegradable polymers, such as poly (l-lactic acid) (PLLA), poly (epsilon-caprolactone) (PCL), and poly (d,l-lactic-co-glycolic acid) (PLGA) were dissolved, along with PEO and lysozyme, in a mixture of chloroform and dimethylsulfoxide (DMSO).
6(0,0,0,6) Details
15667186 Unsworth LD, Sheardown H, Brash JL: Protein resistance of surfaces prepared by sorption of end-thiolated poly (ethylene glycol) to gold: effect of surface chain density. Langmuir. 2005 Feb 1;21(3):1036-41.

Surfaces modified with end-tethered poly (ethylene oxide) (PEO) have been shown to be protein-resistant to some degree.
The adsorption of fibrinogen and lysozyme to these surfaces was investigated.
3(0,0,0,3) Details
17513075 Singh S, Webster DC, Singh J: Thermosensitive polymers: synthesis, characterization, and delivery of proteins. Int J Pharm. 2007 Aug 16;341(1-2):68-77. Epub 2007 Apr 19.

Three triblock copolymers based on the poly (lactide) or poly (lactide-co-glycolide) and poly (ethylene glycol) or poly (ethylene oxide) blocks were synthesized and characterized.
Two formulations each of three synthesized polymers containing 5% (w/v) of lysozyme or bromelain but differing in polymer concentrations (20-30%, w/v) were prepared and studied for in vitro release of the incorporated protein.
3(0,0,0,3) Details
18589433 Hofs B, Brzozowska A, de Keizer A, Norde W, Cohen Stuart MA: Reduction of protein adsorption to a solid surface by a coating composed of polymeric micelles with a glass-like core. J Colloid Interface Sci. 2008 Sep 15;325(2):309-15. Epub 2008 Jun 7.


Experiments were performed with different types of surfaces, solvents, and proteins; bare silica and cross-linked 1,2-PB, NaNO (3) and phosphate buffer, and lysozyme, bovine serum albumin, beta-lactoglobulin, and fibrinogen.
2(0,0,0,2) Details
18167582 Liu G, Chen Y, Zhang G, Yang S: Protein resistance of (ethylene oxide) n monolayers at the air/water interface: effects of packing density and chain length. Phys Chem Chem Phys. 2007 Dec 14;9(46):6073-82. Epub 2007 Oct 10.

In the case of a PEO monolayer, a protein adsorption minimum is revealed at sigma (-1) = 10 nm (2) for both lysozyme and fibrinogen.
2(0,0,0,2) Details
15639458 Bolognese B, Nerli B, Pico G: Application of the aqueous two-phase systems of ethylene and propylene oxide copolymer-maltodextrin for protein purification. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jan 25;814(2):347-53.


In this study, the effect of several factors that govern the partitioning behaviour of three model proteins, such as bovine serum albumin, lysozyme and trypsin was analysed in a two-phase system formed by maltodextrin and a copolymer of ethylene and propylene oxides.
1(0,0,0,1) Details
16903683 Oh KS, Han SK, Lee HS, Koo HM, Kim RS, Lee KE, Han SS, Cho SH, Yuk SH: Core/Shell nanoparticles with lecithin lipid cores for protein delivery. Biomacromolecules. 2006 Aug;7(8):2362-7.

The lipid core is composed of protein-loaded lecithin and the polymeric shell is composed of Pluronics (poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) triblock copolymer, F-127).
For the application of core/shell nanoparticles as a protein drug carrier, lysozyme and vascular endothelial growth factor (VEGF) were loaded into the core/shell nanoparticles by electrostatic interaction, and the drug release pattern was observed by manipulating the polymeric shell.
1(0,0,0,1) Details
15132703 Salloum DS, Schlenoff JB: Protein adsorption modalities on polyelectrolyte multilayers. Biomacromolecules. 2004 May-Jun;5(3):1089-96.

Protein adsorption on polyelectrolyte multilayers (PEMUs) was evaluated using a combination of synthetic polyelectrolytes and proteins, including serum albumin, fibrinogen, and lysozyme.
A diblock copolymer comprising a hydrophilic poly (ethylene oxide) block was capable of further minimizing protein adsorption as a result of hydrophilic repulsion, although none of the surfaces tested defeated protein adsorption completely.
1(0,0,0,1) Details
15887658 Chen H, Brook MA, Chen Y, Sheardown H: Surface properties of PEO-silicone composites: reducing protein adsorption. J Biomater Sci Polym Ed. 2005;16(4):531-48.

Silicone-based polymers with reduced protein adsorption were successfully prepared by incorporating mono- or bifunctional poly (ethylene oxide) (PEO) derivatives, respectively, into PDMS during rubber formation using classic room temperature vulcanization chemistry.
Significant reductions in the adsorption of fibrinogen, albumin and lysozyme were observed on both PEO-modified surfaces, although the monofunctional PEO surfaces performed much better in this regard.
1(0,0,0,1) Details
18655038 Lin CY, Liu CH, Chang HC, Tseng WL: Enrichment and separation of acidic and basic proteins using the centrifugal ultrafiltration followed by nanoparticle-filled capillary electrophoresis. Electrophoresis. 2008 Jul;29(14):3024-31.

To improve stacking and separation efficiencies of proteins, the separation buffer containing 1.6% poly (diallyldimethylammonium chloride) was added with gold nanoparticles (AuNP), poly (ethylene oxide), cetyltrimethylammonium bromide, and poly (vinyl alcohol).
We have validated the application of our method by means of analyses of 50 nM lysozyme in saliva samples.
1(0,0,0,1) Details
18064734 Chiu TC, Tu WC, Chang HT: Stacking and separation of protein derivatives of naphthalene-2,3-dicarboxaldehyde by CE with light-emitting diode induced fluorescence detection. Electrophoresis. 2008 Jan;29(2):433-40.

During the separation, poly (ethylene oxide) (PEO) solution containing CTAB enters from the cathodic inlet to the capillary via electroosomotic flow (EOF).
The efficient stacking approach provides LODs (S/N = 3) of 2.41, 0.59, 0.61, and 4.22 nM for trypsin inhibitor, HSA, beta-lactoglobulin, and lysozyme, respectively.
1(0,0,0,1) Details