| Name | H ras |
|---|---|
| Synonyms | C H RAS; Transforming protein p21; N ras; HRAS1; HRASP; C H ras 1 protein N terminal fragment (37 AA); C has/bas p21 protein; C ras Ki 2 protein… |
| Name | methylene chloride |
|---|---|
| CAS | dichloromethane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7482563 | Maronpot RR, Devereux TR, Hegi M, Foley JF, Kanno J, Wiseman R, Anderson MW: Hepatic and pulmonary carcinogenicity of methylene chloride in mice: a search for mechanisms. Toxicology. 1995 Sep 1;102(1-2):73-81. The frequency and pattern of H-ras gene activation were similar in control and methylene chloride-induced liver neoplasms. |
81(1,1,1,1) | Details |
| 8504471 | Devereux TR, Foley JF, Maronpot RR, Kari F, Anderson MW: Ras proto-oncogene activation in liver and lung tumors from B6C3F1 mice exposed chronically to methylene chloride. Carcinogenesis. 1993 May;14(5):795-801. DNA was isolated from 49 spontaneous and 50 methylene chloride-induced liver tumors and screened by oligonucleotide hybridization of PCR amplified H-ras gene fragments for codon 61 mutations. |
13(0,0,2,3) | Details |
| 10353384 | Sills RC, Boorman GA, Neal JE, Hong HL, Devereux TR: Mutations in ras genes in experimental tumours of rodents. IARC Sci Publ. 1999;(146):55-86. For example: (1) ozone-induced lung neoplasms had two unique mutations, one (codon 61 K-ras CTA mutation) consistent with a direct genotoxic event and a second (codon 12 K-ras G --> T transversion) consistent with an indirect genotoxic effect; (2) isoprene-induced Harderian gland neoplasms had a unique K-ras A --> T transversion at codon 61 which provided evidence that formation of an epoxide intermediate was involved; (3) 1,3-butadiene-induced neoplasms had a characteristic K-ras G --> C transversion mutation at codon 13 which was also consistent with a chemical-specific effect; (4) methylene -induced liver neoplasms had an H-ras mutation profile at codon 61 similar to that of spontaneous tumours, suggesting that methylene chloride promotes cells with 'spontaneously initiated' ras mutations and (5) oxazepam-induced liver neoplasms had a low frequency of ras mutations, suggesting a nonmutagenic pathway of carcinogenesis. |
6(0,0,1,1) | Details |
| 7954475 | Hegi ME, Devereux TR, Dietrich WF, Cochran CJ, Lander ES, Foley JF, Maronpot RR, Anderson MW, Wiseman RW: Allelotype analysis of mouse lung carcinomas reveals frequent allelic losses on chromosome 4 and an association between allelic imbalances on chromosome 6 and K-ras activation. Cancer Res. 1994 Dec 1;54(23):6257-64. We generated allelotypes of 38 methylene chloride-induced lung carcinomas from female C57BL/6J x C3H/6J F1 (hereafter called B6C3F1) mice. |
2(0,0,0,2) | Details |