| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | alpha-cypermethrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15365239 | Manna S, Bhattacharyya D, Mandal TK, Das S: Repeated dose toxicity of alfa-cypermethrin in rats. J Vet Sci. 2004 Sep;5(3):241-5. The present study was performed to investigate the subacute effect of alpha-cypermethrin (alpha-CP) in rats. Activities of various enzymes, cytochrome P450 and b5 contents in liver, hepatic antioxidant status, tissue residue concentration, haemogram and pathological changes were studied. |
3(0,0,0,3) | Details |
| 12144700 | Li X, Berenbaum MR, Schuler MA: Plant allelochemicals differentially regulate Helicoverpa zea cytochrome P450 genes. Insect Mol Biol. 2002 Aug;11(4):343-51. Comparison of the expression levels induced by eight plant allelochemicals, one drug (phenobarbital), and an insecticide (alpha-cypermethrin) indicates that, for the most part, the four P450s respond individually to these inducers, with all four induced strongly by a pathway intermediate and a lignin biosynthesis intermediate present in a wide variety of plants, and a glucobrassicin breakdown product present in the Brassicaceae. |
2(0,0,0,2) | Details |
| 15315820 | Sasabe M, Wen Z, Berenbaum MR, Schuler MA: Molecular analysis of CYP321A1, a novel cytochrome P450 involved in metabolism of plant allelochemicals (furanocoumarins) and insecticides (cypermethrin) in Helicoverpa zea. Gene. 2004 Sep 1;338(2):163-75. In the corn earworm Helicoverpa zea, a noctuid of considerable economic importance, metabolisms of xanthotoxin, a toxic furanocoumarin, and alpha-cypermethrin, an insecticide, are mediated by at least one P450 with a catalytic site capable of accepting both substrates. |
1(0,0,0,1) | Details |
| 18381673 | Margaritopoulos JT, Skavdis G, Kalogiannis N, Nikou D, Morou E, Skouras PJ, Tsitsipis JA, Vontas J: Efficacy of the pyrethroid alpha-cypermethrin against Bactrocera oleae populations from Greece, and improved diagnostic for an iAChE mutation. Pest Manag Sci. 2008 Sep;64(9):900-8. Cytochrome P450 monoxygenase activities showed an association with resistance. |
1(0,0,0,1) | Details |
| 10646973 | Li X, Berenbaum MR, Schuler MA: Molecular cloning and expression of CYP6B8: a xanthotoxin-inducible cytochrome P450 cDNA from Helicoverpa zea. Insect Biochem Mol Biol. 2000 Jan;30(1):75-84. Xanthotoxin, a plant allelochemical, induces alpha-cypermethrin insecticide tolerance in Helicoverpa zea (corn earworm); inhibition of tolerance by piperonyl butoxide implicates cytochrome P450 monooxygenases (P450s) in the detoxification of this insecticide. |
1(0,0,0,1) | Details |
| 20183062 | Abass K, Turpeinen M, Pelkonen O: An evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomes. J Environ Sci Health B. 2009 Aug;44(6):553-63. With the exceptions of alpha-cypermethrin, cypermethrin, isoproturon, carbaryl and abamectin, most pesticides inhibited relatively potently at least one CYP-selective activity, which may have relevance for potential interactions in occupational exposures and for further studies on the CYP-associated metabolism of respective pesticides. |
1(0,0,0,1) | Details |