Protein Information

Name hormone receptor
Synonyms Early response protein NAK1; GFRP 1; GFRP1; Growth factor inducible nuclear protein N10; Growth factor response protein 1; HMR; Hormone receptor; N10…

Compound Information

Name tebufenozide
CAS 3,5-dimethylbenzoic acid 1-(1,1-dimethylethyl)-2-(4-ethylbenzoyl)hydrazide

Reference List

PubMed Abstract RScore(About this table)
11520684 Debernard S, Bozzolan F, Duportets L, Porcheron P: Periodic expression of an ecdysteroid-induced nuclear receptor in a lepidopteran cell line (IAL-PID2). Insect Biochem Mol Biol. 2001 Oct;31(11):1057-64.


A set of DNA primers was designed within the DNA-binding domain of the Manduca hormone receptor 3 (MHR3) cDNA.
4(0,0,0,4) Details
8763167 Palli SR, Ladd TR, Sohi SS, Cook BJ, Retnakaran A: Cloning and developmental expression of Choristoneura hormone receptor 3, an ecdysone-inducible gene and a member of the steroid hormone receptor superfamily. Insect Biochem Mol Biol. 1996 May;26(5):485-99.

3(0,0,0,3) Details
9094210 Palli SR, Ladd TR, Ricci AR, Sohi SS, Retnakaran A: Cloning and development expression of Choristoneura hormone receptor 75: a homologue of the Drosophila E75A gene. Dev Genet. 1997;20(1):36-46.

2(0,0,0,2) Details
12638012 Kasuya A, Sawada Y, Tsukamoto Y, Tanaka K, Toya T, Yanagi M: Binding mode of ecdysone agonists to the receptor: comparative modeling and docking studies. J Mol Model. 2003 Feb;9(1):58-65. Epub 2003 Jan 14.


Two models were created based both on known ligand-binding domain structures of the receptors with the highest sequence identity to the ecdysone receptor, and on those of steroid hormone receptors.
2(0,0,0,2) Details
8641050 Kothapalli R, Palli SR, Ladd TR, Sohi SS, Cress D, Dhadialla TS, Tzertzinis G, Retnakaran A: Cloning and developmental expression of the ecdysone receptor gene from the spruce budworm, Choristoneura fumiferana. Dev Genet. 1995;17(4):319-30.


Degenerate oligonucleotides were designed on the basis of conserved amino acid sequences in the DNA and ligand-binding regions of the members of the steroid hormone receptor superfamily.
2(0,0,0,2) Details
9131779 Palli SR, Ladd TR, Retnakaran A: Cloning and characterization of a new isoform of Choristoneura hormone receptor 3 from the spruce budworm. Arch Insect Biochem Physiol. 1997;35(1-2):33-44.

2(0,0,0,2) Details
14503575 Schneider MI, Smagghe G, Gobbi A, Vinuela E: Toxicity and pharmacokinetics of insect growth regulators and other novel insecticides on pupae of Hyposoter didmator (Hymenoptera: Ichneumonidae), a parasitoid of early larval instars of lepidopteran pests. J Econ Entomol. 2003 Aug;96(4):1054-65.

In addition, we tested for the presence of molting hormone receptors in Hyposoter tissues using a monoclonal antibody 9B9.
Susceptibility of the lepidopteran parasitoid Hyposoter didymator (Thunberg) to seven modern insecticides, azadirachtin, diflubenzuron, halofenozide, methoxyfenozide, pyriproxyfen, tebufenozide, and spinosad, was tested in the laboratory.
1(0,0,0,1) Details
11755068 Sundaram M, Palli SR, Smagghe G, Ishaaya I, Feng QL, Primavera M, Tomkins WL, Krell PJ, Retnakaran A: Effect of RH-5992 on adult development in the spruce budworm, Choristoneura fumiferana. Insect Biochem Mol Biol. 2002 Feb;32(2):225-31.

The effect of RH-5992 (tebufenozide), a non-steroidal ecdysone agonist, on adult development of the spruce budworm, Choristoneura fumiferana, was investigated by administering the compound intrahemocoelically to pupae on days 1-6 after pupal ecdysis.
Injection of RH-5992 into pupae resulted in a dose dependent induction of mRNA for ecdysone-induced transcription factor, Choristoneura hormone receptor 3 (CHR3).
1(0,0,0,1) Details
14745824 Hu W, Cook BJ, Ampasala DR, Zheng S, Caputo G, Krell PJ, Retnakaran A, Arif BM, Feng Q: Morphological and molecular effects of 20-hydroxyecdysone and its agonist tebufenozide on CF-203, a midgut-derived cell line from the spruce budworm, Choristoneura fumiferana. Arch Insect Biochem Physiol. 2004 Feb;55(2):68-78.

The cells responded to these compounds by clumping, generating filamentous extensions, increased mortality and expression of the transcription factor, Choristoneura hormone receptor 3 (CHR3).
1(0,0,0,1) Details
9755479 Sundaram M, Palli SR, Krell PJ, Sohi SS, Dhadialla TS, Retnakaran A: Basis for selective action of a synthetic molting hormone agonist, RH-5992 on lepidopteran insects. Insect Biochem Mol Biol. 1998 Sep;28(9):693-704.


The mRNAs for hormone receptor 3 homologues cloned from Drosophila (DHR3) and Choristoneura (CHR3) are directly induced by 20-hydroxyecdysone (20E) and serve as suitable markers for studying ecdysone action.
1(0,0,0,1) Details
11695189 Retnakaran A, Gelbic I, Sundaram M, Tomkins W, Ladd T, Primavera M, Feng Q, Arif B, Palli R, Krell P: Mode of action of the ecdysone agonist tebufenozide (RH-5992), and an exclusion mechanism to explain resistance to it. Pest Manag Sci. 2001 Oct;57(10):951-7.

0(0,0,0,0) Details