| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | anabasine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14757175 | Denton TT, Zhang X, Cashman JR: -related alkaloids and metabolites as inhibitors of human cytochrome P-450 2A6. Biochem Pharmacol. 2004 Feb 15;67(4):751-6. S-(-)- and 13 of the most prevalent -related alkaloids and metabolites (i.e., S-(-)- myosmine, beta-nicotyrine, S- S- S-(-)- N-1'-oxide, S-(-)- Delta1'-5'-iminium ion, S-(-)-anabasine, S-(-)-N-methylanabasine, anabaseine, S-(-)- nicotelline, and 2,3'-bipyridyl) were evaluated as inhibitors of human cDNA-expressed cytochrome P-450 2A6 (CYP2A6) mediated 7-hydroxylation. |
82(1,1,1,2) | Details |
| 8156919 | Skowronski RJ, Feldman D: Inhibition of synthesis in rat cells by and related constituents of tobacco smoke. Endocrinology. 1994 May;134(5):2171-7. Because synthesis is also cytochrome P450 dependent, we hypothesized a similar inhibitory action on production. In this study we examined the effects of anabasine (a related alkaloid), and (the major metabolite of on in vitro synthesis. |
1(0,0,0,1) | Details |
| 3497305 | Barbieri RL, York CM, Cherry ML, Ryan KJ: The effects of and anabasine on rat 11 beta-hydroxylase and 21-hydroxylase. J Steroid Biochem. 1987 Jul;28(1):25-8. The addition of or anabasine to preparations of rat mitochondria produced type II cytochrome P-450 difference spectra. |
6(0,0,1,1) | Details |
| 15720138 | Dick RA, Kanne DB, Casida JE: Identification of aldehyde oxidase as the neonicotinoid nitroreductase. Chem Res Toxicol. 2005 Feb;18(2):317-23. It is both oxidatively metabolized by cytochrome P450 enzymes and reduced at the nitroguanidine moiety by a previously unidentified cytosolic "neonicotinoid nitroreductase", the subject of this investigation. |
1(0,0,0,1) | Details |