Protein Information

Name Nerve growth factor
Synonyms Beta NGF; Beta nerve growth factor; Beta nerve growth factor precursor; HSAN 5; HSAN5; NGF; NGFB; Nerve growth factor…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19712094 Yamboliev IA, Smyth LM, Durnin L, Dai Y, Mutafova-Yambolieva VN: Storage and secretion of beta-NAD, ATP and dopamine in NGF-differentiated rat pheochromocytoma PC12 cells. Eur J Neurosci. 2009 Sep;30(5):756-68. Epub 2009 Aug 27.

Using high-performance liquid chromatography techniques with electrochemical and fluorescence detection we simultaneously evaluated secretion of dopamine (DA), ATP, adenosine 5'-diphosphate, adenosine 5'-monophosphate, adenosine, beta-NAD and its immediate metabolites ADP-ribose and cyclic ADP-ribose in superfused nerve growth factor-differentiated rat pheochromocytoma PC12 cells. beta-NAD, DA and ATP were released constitutively and upon stimulation with high-K (+) solution or nicotine.
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19824047 Urrego F, Scuri M, Auais A, Mohtasham L, Piedimonte G: Combined effects of chronic nicotine and acute virus exposure on neurotrophin expression in rat lung. Pediatr Pulmonol. 2009 Nov;44(11):1075-84.

Expression of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor, of their high-affinity tyrosine kinase receptors (trkA and trkB, respectively), and of the low-affinity receptor p75 (NTR) was measured in the lungs of nicotine-exposed rats both at the mRNA level by reverse-transcription polymerase chain reaction and at the protein level by enzyme-linked immunoassay.
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20056136 Formaggio E, Fazzini F, Dalfini AC, Di Chio M, Cantu C, Decimo I, Fiorini Z, Fumagalli G, Chiamulera C: Nicotine increases the expression of neurotrophin receptor tyrosine kinase receptor A in basal forebrain cholinergic neurons. Neuroscience. 2010 Mar 17;166(2):580-9. Epub 2010 Jan 4.

In this study, we investigated whether the potential positive effects of nicotine in Alzheimer's disease (AD) may involve neurotrophic factors, such as nerve growth factor (NGF), closely associated with basal forebrain (BF) cholinergic function and survival.
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19410565 Son JH, Winzer-Serhan UH: Chronic neonatal nicotine exposure increases mRNA expression of neurotrophic factors in the postnatal rat hippocampus. Brain Res. 2009 Jun 30;1278:1-14. Epub 2009 May 3.

Therefore, we determined whether chronic neonatal nicotine (CNN) exposure increased mRNA expression levels of brain-derived neurotrophic factor (BDNF), nerve-growth factor (NGF), neurotrophin-3 (NT-3), fibroblast growth factor-2 (FGF-2), and insulin-like growth factor-1 (IGF-1).
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19830843 Nai Q, Wang X, Jin Y, Sun D, Li M, Hu B, Zhang X: Ciliary neurotrophic factor enhances nicotinic synaptic transmission in sympathetic neurons. J Neurosci Res. 2010 Mar;88(4):887-95.


In this study, we found that CNTF dramatically enhanced the frequency and amplitude of nicotinic excitatory post-synaptic currents in rat superior cervical ganglion neurons maintained in a medium supplemented with nerve growth factor.
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