Protein Information

Name IL 12 (protein family or complex)
Synonyms Cytotoxic lymphocyte maturation factor; Cytotoxic lymphocyte maturation factors; IL 12; IL12; Natural killer cell stimulatory factor; Natural killer cell stimulatory factors

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19729077 Jeong GS, Lee SH, Jeong SN, Kim YC, Kim EC: Anti-inflammatory effects of apigenin on nicotine- and lipopolysaccharide-stimulated human periodontal ligament cells via heme oxygenase-1. Int Immunopharmacol. 2009 Nov;9(12):1374-80. Epub 2009 Sep 1.

Apigenin significantly inhibited the nicotine- and LPS-induced production of NO, PGE2, IL-1beta, TNF-alpha, IL-6, and IL-12, and the upregulation of iNOS and COX-2 in hPDL cells.
82(1,1,1,2) Details
19646418 Yanagita M, Kobayashi R, Murakami S: Nicotine can skew the characterization of the macrophage type-1 (MPhi1) phenotype differentiated with granulocyte-macrophage colony-stimulating factor to the MPhi2 phenotype. Biochem Biophys Res Commun. 2009 Oct 9;388(1):91-5. Epub 2009 Jul 29.

Ni-MPhi1 suppressed IL-12, but maintained IL-10 and produced high amounts of MCP-1 upon lipopolysaccharide stimulation compared with MPhi1.
1(0,0,0,1) Details