| Name | phosphatidylinositol 3 kinase (protein family or complex) |
|---|---|
| Synonyms | PI3 kinase; PI3 kinases; PI3K; Phosphatidylinositol 3 kinase; Phosphatidylinositol 3 kinases; Phosphatidylinositol 4,5 bisphosphate 3 kinase; Phosphatidylinositol 4,5 bisphosphate 3 kinases |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19654299 | Sun X, Ritzenthaler JD, Zhong X, Zheng Y, Roman J, Han S: Nicotine stimulates PPARbeta/delta expression in human lung carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha. Cancer Res. 2009 Aug 15;69(16):6445-53. Epub 2009 Aug 4. Here, we explore the potential link between nicotine and PPARbeta/delta and report that nicotine increases the expression of PPARbeta/delta protein; this effect was blocked by an alpha7 nAChR antagonist (alpha-bungarotoxin), by alpha7 nAChR short interfering RNA, and by inhibitors of phosphatidylinositol 3-kinase (PI3K; wortmannin and LY294002) and mammalian target of rapamycin (mTOR; rapamycin). |
81(1,1,1,1) | Details |
| 20173312 | Takada-Takatori Y, Kume T, Izumi Y, Niidome T, Fujii T, Sugimoto H, Akaike A: Mechanisms of chronic nicotine treatment-induced enhancement of the sensitivity of cortical neurons to the neuroprotective effect of in cortical neurons. J Pharmacol Sci. 2010 Mar 19;112(3):265-72. Epub 2010 Feb 20. Analyses with receptor antagonists and kinase inhibitors revealed that the effects of chronic nicotine treatment are mediated by nicotinic receptors and their downstream effectors including phosphatidylinositol 3-kinase. |
81(1,1,1,1) | Details |
| 19293145 | Buckingham SD, Jones AK, Brown LA, Sattelle DB: Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. Pharmacol Rev. 2009 Mar;61(1):39-61. Epub 2009 Mar 16. Abeta peptides and nicotine differentially activate several intracellular signaling pathways, including the phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homolog pathway, the extracellular signal-regulated kinase/mitogen-activated protein kinase, and JAK-2/STAT-3 pathways. |
81(1,1,1,1) | Details |
| 19252273 | Shimohama S: Nicotinic receptor-mediated neuroprotection in neurodegenerative disease models. Biol Pharm Bull. 2009 Mar;32(3):332-6. Nicotine-induced protection was blocked by an alpha7 nAChR antagonist, a phosphatidylinositol 3-kinase (PI3K) inhibitor, and an Src inhibitor. |
31(0,1,1,1) | Details |
| 20338106 | Shen T, Le W, Yee A, Kamdar O, Hwang PH, Upadhyay D: Nicotine induces resistance to chemotherapy in nasal epithelial cancer. . Am J Rhinol Allergy. 2010 Mar;24(2):e73-7. Furthermore, nicotine induced activation of AKT and MAPK pathways, while inhibition of MAPK using U0126 and AKT by phosphatidylinositol 3-kinase inhibitor, LY294002, in part, blocked the antiapoptotic effects of nicotine against cisplatin and etoposide-induced apoptosis in NC. |
31(0,1,1,1) | Details |
| 19714494 | Akaike A, Takada-Takatori Y, Kume T, Izumi Y: Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection. J Mol Neurosci. 2010 Jan;40(1-2):211-6. Furthermore, a phosphatidylinositol 3-kinase (PI3K) inhibitor also suppressed the neuroprotective effect of the AChE inhibitors. |
1(0,0,0,1) | Details |