| Name | CYP2B6 |
|---|---|
| Synonyms | CPB 6; CPB6; CYP2B; CYP2B protein; CYP2B6; CYPIIB 6; CYPIIB6; Cytochrome P450 2B6… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19019380 | Petsalo A, Turpeinen M, Pelkonen O, Tolonen A: Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatography-tandem mass spectrometry utilizing sub 2 microm particle size column. J Chromatogr A. 2008 Dec 26;1215(1-2):107-15. Epub 2008 Nov 7. CYP-specific metabolites of (CYP1A2), nicotine (CYP2A6), (CYP2B6), repaglinide (CYP2C8), losartan (CYP2C9), (CYP2C19 and CYP3A4), dextromethorphan (CYP2D6), chlorzoxazone (CYP2E1) and midazolam (CYP3A4) were all analyzed using the same LC/MS/MS method with a single analytical run, either after a one-at-a-time dose or cocktail-type dosing of the parent drugs. |
31(0,1,1,1) | Details |
| 20307138 | Al Koudsi N, Tyndale RF: Hepatic CYP2B6 is altered by genetic, physiologic, and environmental factors but plays little role in nicotine metabolism. Xenobiotica. 2010 Mar 22. The objective was twofold: (1) to determine the role of genetic, physiological, and environmental factors in predicting hepatic CYP2B6 protein expression; and (2) to investigate the role of CYP2B6 in nicotine C-oxidation. |
67(0,2,2,7) | Details |
| 19251795 | Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ: Genetic variation as a predictor of smoking cessation success. Eur Respir J. 2009 Mar;33(3):468-80. Recently, it has been shown that genetic variants in the dopaminergic system, opioid receptors, the -metabolising enzyme CYP2B6 and the nicotine-metabolising enzyme CYP2A6 may play an important role in predicting smoking cessation responses to nicotine replacement therapy and treatment. |
31(0,1,1,1) | Details |
| 19169923 | Ray R, Tyndale RF, Lerman C: Nicotine dependence pharmacogenetics: role of genetic variation in nicotine-metabolizing enzymes. J Neurogenet. 2009;23(3):252-61. Epub 2009 Jan 23. Inherited variation in the CYP2B6 enzyme is also associated with response to treatment and counseling alone for smoking cessation. |
1(0,0,0,1) | Details |