| Name | NMDA receptor (protein family or complex) |
|---|---|
| Synonyms | Glutamate [NMDA] receptor; Glutamate [NMDA] receptors; N methyl D aspartate receptor; N methyl D aspartate receptors; NMDA receptor; NMDA receptors |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19595736 | Zheng P: Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance. Prog Neurobiol. 2009 Oct;89(2):134-52. Epub 2009 Jul 10. Many of them involve rapid non-genomic effects on presynaptic receptors and ion channels like sigma-1 receptor, alpha (1) receptor, nicotine receptor, D1 receptor, NMDA receptor, (A) receptor and L-type Ca (2+) channels. |
81(1,1,1,1) | Details |
| 20062537 | Wang LP, Li F, Shen X, Tsien JZ: Conditional knockout of NMDA receptors in neurons prevents nicotine-conditioned place preference. PLoS One. 2010 Jan 7;5(1):e8616. By generating neuron-specific NR1 knockout mice using cre/loxP-mediated method, we demonstrate that genetic inactivation of the NMDA receptors in ventral tegmental area neurons selectively prevents nicotine-conditioned place preference. |
43(0,1,3,3) | Details |
| 20105181 | Huang LT, Sherwood JL, Sun YJ, Lodge D, Wang Y: Activation of presynaptic alpha7 nicotinic receptors evokes an excitatory response in hippocampal CA3 neurones in anaesthetized rats: an in vivo iontophoretic study. Br J Pharmacol. 2010 Jan 26. In addition, the excitation induced by iontophoretic application of nicotine, AR-R17779 or PSAB-OFP was also blocked by co-iontophoretic application of either 6,7-dinitroquinoxaline-2,3-dione (DNQX) or D (2)-2-amino-5-phosphonopentanoate (D-AP5), selective and non-NMDA receptor antagonists respectively. |
32(0,1,1,2) | Details |
| 20035769 | Rezayof A, Shirazi-Zand Z, Zarrindast MR, Nayer-Nouri T: Nicotine improves -induced memory impairment: the role of dorsal hippocampal NMDA receptors. Life Sci. 2010 Feb 13;86(7-8):260-6. Epub 2009 Dec 24. |
7(0,0,1,2) | Details |
| 19464268 | Placzek AN, Zhang TA, Dani JA: Age dependent nicotinic influences over neuron synaptic plasticity. Biochem Pharmacol. 2009 Oct 1;78(7):686-92. Epub 2009 May 21. Addictive drugs, including nicotine, exert powerful influences over the mesolimbic DA system by activating and desensitizing nicotinic acetylcholine receptors (nAChRs) in a subtype-dependent manner. This change in glutamatergic transmission is expressed as an increased ratio of AMPA receptors to NMDA receptors at glutamatergic synapses. |
1(0,0,0,1) | Details |
| 19840815 | Simmons MA, Werkheiser JL, Hudzik TJ: Acute nicotine and phencyclidine increase locomotor activity of the guinea pig with attenuated potencies relative to their effects on rat or mouse. Pharmacol Biochem Behav. 2010 Jan;94(3):410-5. Epub 2009 Oct 17. The goal of this study was to determine the utility of the guinea pig as a model for assessing the behavioral actions of nicotinic receptor agonists and NMDA receptor antagonists. |
1(0,0,0,1) | Details |
| 19767248 | Kuo JS, Leung YM, Lin NN, Lee TJ, Gong CL: Nicotine stimulation of the medulla increases blood flow of the common carotid artery in cats. Auton Neurosci. 2010 Jan 15;152(1-2):49-54. Epub 2009 Sep 19. The nicotine- and -induced increases were reduced by alpha-bungarotoxin (an alpha7-nAChR antagonist) as well as MK-801 (a non-competitive NMDA receptor antagonist) or diethylester (a competitive AMPA/kainate receptor antagonist). |
31(0,1,1,1) | Details |
| 20066400 | Rowland LM, Beason-Held L, Tamminga CA, Holcomb HH: The interactive effects of ketamine and nicotine on human cerebral blood flow. Psychopharmacology. 2010 Jan 13. CONCLUSION: This study illustrates the interactive effects of ketamine, an NMDA receptor antagonist, and nicotine in multiple brain regions. |
31(0,1,1,1) | Details |
| 19091927 | Kamendi HW, Cheng Q, Dergacheva O, Gorini C, Jameson HS, Wang X, McIntosh JM, Mendelowitz D: Abolishment of serotonergic neurotransmission to cardiac vagal neurons during and after hypoxia and hypercapnia with prenatal nicotine exposure. J Neurophysiol. 2009 Mar;101(3):1141-50. Epub 2008 Dec 17. In contrast to unexposed animals, in PNN animals H/H recruited excitatory neurotransmission to CVNs during inspiratory-related activity that was blocked by the alpha3beta4 nicotinic acetylcholine receptor (nAChR) blocker alpha-conotoxin AuIB (alpha-CTX AuIB, 100 microM) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 50 microM) and d (-)-2-amino-5-phosphonopentanoic acid (AP5, 50 microM), selective AMPA/kainate and N-methyl-d-aspartate receptor blockers, respectively. |
1(0,0,0,1) | Details |
| 19799936 | Uslaner JM, Drott JT, Sharik SS, Theberge CR, Sur C, Zeng Z, Williams DL, Hutson PH: Inhibition of transporter 1 attenuates nicotine- but not food-induced cue-potentiated reinstatement for a response previously paired with Behav Brain Res. 2010 Feb 11;207(1):37-43. Epub 2009 Sep 30. RATIONALE: Compounds which decrease NMDA receptor functioning, such as PCP and ketamine have abuse liability, whereas co-agonists of the NMDA receptor attenuate some of the behavioral and neurochemical effects of stimulant drugs. |
1(0,0,0,1) | Details |
| 19616570 | Zielinska E, Kuc D, Zgrajka W, Turski WA, Dekundy A: Long-term exposure to nicotine markedly reduces in rat brain--in vitro and ex vivo evidence. Toxicol Appl Pharmacol. 2009 Oct 15;240(2):174-9. Epub 2009 Jul 17. (KYNA) is a recognized broad-spectrum antagonist of excitatory amino acid receptors with a particularly high affinity for the co-agonist site of the (NMDA) receptor complex. |
1(0,0,0,1) | Details |
| 20041473 | Zawertailo LA, Tyndale RF, Busto U, Sellers EM: Effect of metabolic blockade on the psychoactive effects of dextromethorphan. Hum Psychopharmacol. 2010 Jan;25(1):71-9. OBJECTIVE: Variation in the activity of cytochrome P450 2D6 (CYP2D6) affects the pharmacokinetics and effectiveness of dextromethorphan (DM), because it controls the production of dextrorphan, an active metabolite, with higher affinity for the NMDA receptor than the parent compound. |
1(0,0,0,1) | Details |
| 20113344 | Jia Y, Yamazaki Y, Nakauchi S, Ito K, Sumikawa K: Nicotine facilitates long-term potentiation induction in oriens-lacunosum moleculare cells via Ca2+ entry through non-alpha7 nicotinic acetylcholine receptors. Eur J Neurosci. 2010 Feb;31(3):463-76. Epub 2010 Jan 26. |
0(0,0,0,0) | Details |
| 19182447 | Kohnomi S, Suemaru K, Kawasaki H, Choshi T, Hibino S, Araki H: [Nicotinic acetylcholine receptors are possible therapeutic targets for schizophrenia]. Yakugaku Zasshi. 2009 Feb;129(2):197-201. We have revealed that nicotine ameliorates the disruption of the PPI, a model of sensorimotor gating, which is induced by apomorphine, a receptor agonist, but is not effective for the disruption of the PPI induced by phencyclidine, a NMDA receptor antagonist, in rats. |
0(0,0,0,0) | Details |