| Name | CHRNB2 |
|---|---|
| Synonyms | CHRNB 2; CHRNB2; EFNL 3; EFNL3; Neuronal acetylcholine receptor protein subunit beta 2; Neuronal acetylcholine receptor protein subunit beta 2 precursor; nAChRB2; Neuronal acetylcholine receptor protein subunit beta 2s… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19698703 | Landgren S, Engel JA, Andersson ME, Gonzalez-Quintela A, Campos J, Nilsson S, Zetterberg H, Blennow K, Jerlhag E: Association of nAChR gene haplotypes with heavy alcohol use and body mass. Brain Res. 2009 Dec 11;1305 Suppl:S72-9. Epub 2009 Aug 19. This study includes a Spanish population (n=417) of three groups based on their consumption; abstainers (n=142), moderate (<280 g/week, n=111) and heavy drinkers (> 280 g/week, n=164). 20 tag SNPs in five nicotine receptor subunit genes (CHRNA3, 4, and 6; CHRNB2 and 3) were genotyped and analysed for single marker and haplotype associations. |
81(1,1,1,1) | Details |
| 19755656 | Perkins KA, Lerman C, Mercincavage M, Fonte CA, Briski JL: Nicotinic acetylcholine receptor beta2 subunit (CHRNB2) gene and short-term ability to quit smoking in response to nicotine patch. Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2608-12. Epub 2009 Sep 15. |
43(0,1,3,3) | Details |
| 19383498 | Hoda JC, Wanischeck M, Bertrand D, Steinlein OK: Pleiotropic functional effects of the first epilepsy-associated mutation in the human CHRNA2 gene. FEBS Lett. 2009 May 19;583(10):1599-604. Epub 2009 Apr 19. We demonstrate here that alpha2-I279N can be co-expressed with the major structural subunit CHRNB2. alpha2-I279N causes a marked gain-of-function effect and displays a distinct biopharmacological profile, including markedly reduced inhibition by carbamazepine and increased nicotine sensitivity. |
32(0,1,1,2) | Details |
| 19020039 | Zhu G, Okada M, Yoshida S, Ueno S, Mori F, Takahara T, Saito R, Miura Y, Kishi A, Tomiyama M, Sato A, Kojima T, Fukuma G, Wakabayashi K, Hase K, Ohno H, Kijima H, Takano Y, Mitsudome A, Kaneko S, Hirose S: Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype. J Neurosci. 2008 Nov 19;28(47):12465-76. Mutations of genes encoding alpha4, beta2, or alpha2 subunits (CHRNA4, CHRNB2, or CHRNA2, respectively) of nAChR [neuronal nicotinic (acetylcholine) receptor] cause nocturnal frontal lobe epilepsy (NFLE) in human. |
1(0,0,0,1) | Details |