Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19526844 Bondarenko OI, Sahach VF: [Modulation of electrical responses of endothelial cells by nicotinic cholinoreceptors]. Fiziol Zh. 2009;55(2):17-23.

Because the sustained component of hyperpolarization of endothelial cells evoked by acetylcholine in isolated rat aorta may partially be mediated by the reversed Na (+)-Ca (2+) exchanger and Na (+)-K (+) ATPase, the mechanisms which transport Na (+) out of cells, we compared the electrical responses of endothelial cells from isolated rat aorta to acetylcholine with other Ca (2+) mobilizing agents and studied the effect of nicotine on endothelial membrane potential in order to asses the functional activity of nicotinic cholinoreceptors.
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19735287 Griguoli M, Scuri R, Ragozzino D, Cherubini E: Activation of nicotinic acetylcholine receptors enhances a slow calcium-dependent potassium conductance and reduces the firing of stratum oriens interneurons. Eur J Neurosci. 2009 Sep;30(6):1011-22. Epub 2009 Sep 4.

Furthermore, blocking ryanodine receptors with ryanodine or sarcoplasmic-endoplasmic reticulum calcium ATPase with thapsygargin or cyclopiazonic acid fully prevented the effects of nicotine, suggesting that mobilization of calcium from the internal stores contributed to the observed effects.
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19294456 Shao T, Yuan H, Yan B, Lu Z, Min H: Antioxidant enzyme activity in bacterial resistance to nicotine toxicity by reactive oxygen species. Arch Environ Contam Toxicol. 2009 Oct;57(3):456-62. Epub 2009 Mar 18.

We analyzed superoxide dismutase (SOD), catalase (CAT), and ATPase activities in the highly nicotine-degrading strain Pseudomonas sp.
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19168636 Morita M, Shitan N, Sawada K, Van Montagu MC, Inze D, Rischer H, Goossens A, Oksman-Caldentey KM, Moriyama Y, Yazaki K: Vacuolar transport of nicotine is mediated by a multidrug and toxic compound extrusion (MATE) transporter in Nicotiana tabacum. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2447-52. Epub 2009 Jan 23.

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