Protein Information

Name beta catenin
Synonyms Beta catenin; CTNNB; CTNNB 1; CTNNB1; Catenin beta; Catenin beta 1; OK/SW cl.35; PRO2286…

Compound Information

Name nicotine
CAS

Reference List

PubMed Abstract RScore(About this table)
19841737 Davis R, Rizwani W, Banerjee S, Kovacs M, Haura E, Coppola D, Chellappan S: Nicotine promotes tumor growth and metastasis in mouse models of lung cancer. PLoS One. 2009 Oct 20;4(10):e7524.

In addition, nicotine significantly reduced the expression of epithelial markers, E-Cadherin and beta-Catenin as well as the tight junction protein ZO-1; these tumors also showed an increased expression of the alpha (7) nAChR subunit.
81(1,1,1,1) Details
19429245 Tian D, Zhu M, Li J, Ma Y, Wu R: Cigarette smoke extract induces activation of beta-catenin/TCF signaling through inhibiting GSK3beta in human alveolar epithelial cell line. Toxicol Lett. 2009 May 22;187(1):58-62. Epub 2009 Feb 10.

4(0,0,0,4) Details