| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19251817 | DeVore NM, Smith BD, Wang JL, Lushington GH, Scott EE: Key residues controlling binding of diverse ligands to human cytochrome P450 2A enzymes. Drug Metab Dispos. 2009 Jun;37(6):1319-27. Epub 2009 Feb 27. To determine differences in binding for a diverse set of cytochrome P450 2A ligands, we have measured the spectral binding affinities (K (D)) for nicotine, phenethyl isothiocyanate (PEITC), 2'-methoxyacetophenone (MAP), and 8-methoxypsoralen. |
82(1,1,1,2) | Details |
| 19434638 | Chougnet A, Woggon WD, Locher E, Schilling B: Synthesis and in vitro activity of heterocyclic inhibitors of CYP2A6 and CYP2A13, two cytochrome P450 enzymes present in the respiratory tract. Chembiochem. 2009 Jun 15;10(9):1562-7. These compounds were tested as inhibitors of CYP2A6 and CYP2A13--two cytochrome P450 enzymes present in the respiratory tract--with a view to preventing the formation of carcinogenic metabolites of nicotine and inhibiting the metabolism of fragrances. 1-Substituted imidazoles bearing short alkyl chains displayed IC (50) values of around 2 microM for both enzymes, together with high vapour pressures. |
32(0,1,1,2) | Details |
| 19034796 | Lee S, Busby AL, Timchalk C, Poet TS: Effects of nicotine exposure on in vitro metabolism of chlorpyrifos in male Sprague-Dawley rats. J Toxicol Environ Health A. 2009;72(2):74-82. Some basic marker substrate activities were also investigated to ensure that nicotine exerted effects on CYP450 activities. |
32(0,1,1,2) | Details |
| 20097188 | Lee S, Poet TS, Smith JN, Busby-Hjerpe AL, Timchalk C: Effect of in vivo nicotine exposure on chlorpyrifos pharmacokinetics and pharmacodynamics in rats. Chem Biol Interact. 2010 Mar 30;184(3):449-57. Epub 2010 Jan 25. The extent of brain acetylcholinesterase (AChE) inhibition was reduced due to nicotine co-exposure consistent with an increase in CYP450-mediated dearylation (detoxification) versus desulfuration. |
31(0,1,1,1) | Details |
| 19285975 | Yue J, Khokhar J, Miksys S, Tyndale RF: Differential induction of -metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary intake. Eur J Pharmacol. 2009 May 1;609(1-3):88-95. Epub 2009 Mar 13. We investigated the influences of chronic nicotine treatment and voluntary intake on the induction of rat hepatic cytochrome P450 (CYP) enzymes that metabolize and nicotine. |
31(0,1,1,1) | Details |
| 19019380 | Petsalo A, Turpeinen M, Pelkonen O, Tolonen A: Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatography-tandem mass spectrometry utilizing sub 2 microm particle size column. J Chromatogr A. 2008 Dec 26;1215(1-2):107-15. Epub 2008 Nov 7. CYP-specific metabolites of (CYP1A2), nicotine (CYP2A6), (CYP2B6), repaglinide (CYP2C8), losartan (CYP2C9), (CYP2C19 and CYP3A4), dextromethorphan (CYP2D6), chlorzoxazone (CYP2E1) and midazolam (CYP3A4) were all analyzed using the same LC/MS/MS method with a single analytical run, either after a one-at-a-time dose or cocktail-type dosing of the parent drugs. |
2(0,0,0,2) | Details |
| 19995643 | Ramchandran K, Patel JD: Sex differences in susceptibility to carcinogens. Semin Oncol. 2009 Dec;36(6):516-23. These factors include differences in female physiology such as bronchial responsiveness and airway size, sex-based differences in nicotine metabolism via the cytochrome p450 system driven by hormones, and differences in DNA repair capacity, as well as the evolution of cigarettes. These factors include differences in female physiology such as bronchial responsiveness and airway size, sex-based differences in nicotine metabolism via the cytochrome p450 system driven by hormones, and differences in DNA repair capacity, as well as the evolution of cigarettes. |
1(0,0,0,1) | Details |
| 19490292 | Schaffer SD, Yoon S, Zadezensky I: A review of smoking cessation: potentially risky effects on prescribed medications. J Clin Nurs. 2009 Jun;18(11):1533-40. RESULTS: Although much of the evidence is case report, dosage adjustments are clearly indicated for clozapine and since they are metabolised by cytochrome P450 CYP1A2 and also have narrow therapeutic ratios. Because the effect on hepatic microsomal enzymes is not related to the nicotine component of tobacco, nicotine replacement will not alter the effect. |
1(0,0,0,1) | Details |
| 20015843 | Pickett G, Seagrave J, Boggs S, Polzin G, Richter P, Tesfaigzi Y: Effects of 10 cigarette smoke condensates on primary human airway epithelial cells by comparative gene and cytokine expression studies. Toxicol Sci. 2010 Mar;114(1):79-89. Epub 2009 Dec 15. We compared changes in gene expression and cytokine production in primary normal human bronchial epithelial cells following treatment for 18 h with cigarette smoke condensates (CSCs) prepared from five commercial and four research cigarettes, at doses of approximately 4 microg/ml nicotine. Cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) and NAD (P) H dehydrogenase, 1 (NQO-1) were selected for validation with quantitative real-time PCR (qRT-PCR) and Western blot analyses. |
1(0,0,0,1) | Details |