| Name | IL 1beta |
|---|---|
| Synonyms | Catabolin; IL 1; IL 1 beta; IL 1B; IL1 beta; IL1B; IL1F2; Interleukin 1… |
| Name | nicotine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20223588 | Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S: Macrophage inflammatory protein-1alpha mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1beta up-regulation. Pain. 2010 Mar 9. Perineural injection of nicotine (20nmol), a macrophage suppressor, prevented PSL-induced neuropathic pain and suppressed MIP-1alpha and IL-1beta expressions. |
84(1,1,1,4) | Details |
| 19602125 | Ho YC, Yang SF, Huang FM, Chang YC: Up-regulation of osteolytic mediators in human osteosarcoma cells stimulated with nicotine. J Periodontal Res. 2009 Dec;44(6):760-6. Epub 2009 Jul 8. The aim of this study was to investigate the expression of interleukin-1, interleukin-8, receptor activator of nuclear factor-kappaB ligand (RANKL), gelatinases and tissue-type plasminogen activator in U2OS cells (from the human osteosarcoma cell line) stimulated with nicotine. |
69(0,2,3,4) | Details |
| 19732285 | Hosur V, Leppanen S, Abutaha A, Loring RH: Gene regulation of alpha4beta2 nicotinic receptors: microarray analysis of nicotine-induced receptor up-regulation and anti-inflammatory effects. J Neurochem. 2009 Nov;111(3):848-58. Epub 2009 Sep 1. Nicotine suppresses IL-1beta and IL-6 expression at least in part by inhibiting NFkappaB activation. |
82(1,1,1,2) | Details |
| 19729077 | Jeong GS, Lee SH, Jeong SN, Kim YC, Kim EC: Anti-inflammatory effects of on nicotine- and lipopolysaccharide-stimulated human periodontal ligament cells via heme oxygenase-1. Int Immunopharmacol. 2009 Nov;9(12):1374-80. Epub 2009 Sep 1. significantly inhibited the nicotine- and LPS-induced production of NO, IL-1beta, TNF-alpha, IL-6, and IL-12, and the upregulation of iNOS and COX-2 in hPDL cells. |
82(1,1,1,2) | Details |
| 20337880 | Johnson GK, Guthmiller JM, Joly S, Organ CC, Dawson DV: Interleukin-1 and interleukin-8 in nicotine- and lipopolysaccharide-exposed gingival keratinocyte cultures. J Periodontal Res. 2010 Mar 9. Conclusion: These results demonstrate that nicotine and LPS differentially regulate IL-1 and IL-8 production by gingival keratinocytes. |
43(0,1,3,3) | Details |
| 20309583 | Wang XJ, Liu YF, Wang QY, Tsuruoka M, Ohta K, Wu SX, Yakushiji M, Inoue T: Functional expression of alpha7 nicotinic acetylcholine receptors in human periodontal ligament fibroblasts and rat periodontal tissues. Cell Tissue Res. 2010 Mar 23. The expressions of alpha7 nAChR and IL-1beta were significantly increased by nicotine administration, whereas alpha-Btx treatment partially suppressed these effects. |
38(0,1,2,3) | Details |
| 19673871 | Tsutakawa S, Kobayashi D, Kusama M, Moriya T, Nakahata N: Nicotine enhances skin necrosis and expression of inflammatory mediators in a rat pressure ulcer model. Br J Dermatol. 2009 Nov;161(5):1020-7. Epub 2009 Jun 11. To clarify the mechanism of the effect of nicotine, mRNA levels of cyclooxygenase-2 (COX-2), interleukin (IL)-1beta, IL-6 and inducible synthase (iNOS) and protein expression of COX-2 and iNOS in the necrotic area were investigated by real-time reverse transcription-polymerase chain reaction and Western blotting, respectively. |
37(0,1,2,2) | Details |
| 19626424 | Kondo Y, Tachikawa E, Ohtake S, Kudo K, Mizuma K, Kashimoto T, Irie Y, Taira E: Inflammatory cytokines decrease the expression of nicotinic acetylcholine receptor during the cell maturation. Mol Cell Biochem. 2010 Jan;333(1-2):57-64. Epub 2009 Jul 22. Furthermore, we examined the ability of the cells to release cytokine when stimulated with both nicotine and LPS and showed that the stimulation with LPS augmented the secretion of IL-1a, IL-1b, IL-6, and TNF-alpha. |
31(0,1,1,1) | Details |
| 19171179 | Delbro D, Westerlund A, Bjorklund U, Hansson E: In inflammatory reactive astrocytes co-cultured with brain endothelial cells nicotine-evoked Ca (2+) transients are attenuated due to interleukin-1beta release and rearrangement of actin filaments. Neuroscience. 2009 Mar 17;159(2):770-9. Epub 2009 Jan 9. |
20(0,0,3,5) | Details |
| 20230807 | Singh K, Singh S, Singhal NK, Sharma A, Parmar D, Singh MP: Nicotine- and -mediated changes in gene expression patterns of MPTP-lesioned mouse striatum: Implications in neuroprotection mechanism. Chem Biol Interact. 2010 Mar 15. The expression levels of toll-interleukin-1 receptor domain-containing adaptor protein, nuclear protein-1, cathepsin B, interleukin-4 receptor, caspase 9, complement component-1, heat shock protein-1 and cytochrome c-oxidase-VIIc were validated by quantitative real-time polymerase chain reaction (qRT-PCR). |
1(0,0,0,1) | Details |
| 19619852 | Li DJ, Tang Q, Shen FM, Su DF, Duan JL, Xi T: Overexpressed alpha7 nicotinic acetylcholine receptor inhibited proinflammatory cytokine release in NIH3T3 cells. J Biosci Bioeng. 2009 Aug;108(2):85-91. To evaluate the anti-inflammation activity of the over-expressed alpha7nAChR, TNF-alpha, IL-6, and IL-1beta release induced by lipopolysaccharide was determined. No changes were found between NIH3T3-pIRES2-EGFP and NIH3T3-pIRES2-EGFP-alpha7nAChR culture supernatant under LPS challenge, however under nicotine pre-stimulation, pro-inflammatory cytokine release was significantly attenuated in alpha7nAChR transfected cell line. |
1(0,0,0,1) | Details |
| 19593403 | Rosas-Ballina M, Goldstein RS, Gallowitsch-Puerta M, Yang L, Valdes-Ferrer SI, Patel NB, Chavan S, Al-Abed Y, Yang H, Tracey KJ: The selective alpha7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2, TLR3, TLR4, TLR9, and RAGE. Mol Med. 2009 Jul-Aug;15(7-8):195-202. Epub 2009 Apr 27. We report here our findings that GTS-21 attenuates tumor necrosis factor (TNF) and interleukin 1beta levels in human whole blood activated by exposure to endotoxin. The suppressive effect of GTS-21 was more potent than nicotine in whole blood and monocytes. |
1(0,0,0,1) | Details |