| Name | peroxisome proliferator activated receptor |
|---|---|
| Synonyms | NR1C1; PPAR; PPAR alpha; PPARA; PPARalpha; Peroxisome proliferator activated receptor; Peroxisome proliferator activated receptor alpha; hPPAR… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15157275 | Wang C, Youssef J, Cunningham M, Badr M: Correlation between thyroid hormone status and hepatic hyperplasia and hypertrophy caused by the peroxisome proliferator-activated receptor alpha agonist Wy-14,643. J Carcinog. 2004 May 24;3(1):9. BACKGROUND: The metabolic inhibitor rotenone inhibits hepatocellular proliferation and the incidence of liver cancer resulting from exposure to the PPARalpha agonist Wy-14,643, via unknown mechanisms. |
165(2,2,2,5) | Details |
| 15545227 | Scatena R, Martorana GE, Bottoni P, Giardina B: Mitochondrial dysfunction by synthetic ligands of peroxisome proliferator activated receptors (PPARs). IUBMB Life. 2004 Aug;56(8):477-82. A re-evaluation of the biological activities of PPAR synthetic ligands, in particular of the mitochondrial dysfunction based on a rotenone-like Complex I partial inhibition and of its consequent metabolic adaptations, seems to explain some of the pathophysiologic aspects of PPARs allowing a better definition of the therapeutic properties of the so-called PPAR-ligands. |
83(1,1,1,3) | Details |
| 15183193 | Atarod EB, Kehrer JP: Dissociation of oxidant production by peroxisome proliferator-activated receptor ligands from cell death in human cell lines. Free Radic Biol Med. 2004 Jul 1;37(1):36-47. Rotenone and antimycin A prevented Wy14643- but not ciglitazone-induced oxidant production. |
5(0,0,0,5) | Details |
| 19693701 | Lu RH, Ji H, Chang ZG, Su SS, Yang GS: Mitochondrial development and the influence of its dysfunction during rat adipocyte differentiation. Mol Biol Rep. 2009 Aug 20. The mRNA expression levels of mitochondrial gene including cytochromes c (Cyt c), malate dehydrogenases (MDH), and peroxisome proliferator activated receptor (PPAR) gamma coactivator-1beta (PGC-1beta) significantly increased along with the proceeding of adipocyte differentiation. The damage to mitochondrial respiratory chain function by rotenone caused significant decrease in gene expressions including mitochondrial MDH and PGC-1beta, and PPARgamma, CAAT/enhancer binding protein alpha (C/EBPalpha) and sterol regulatory element binding protein-1c (SREBP-1c), which are known as transcription factors of differentiation, and differentiation marker gene named fatty acid synthetase. |
1(0,0,0,1) | Details |
| 15729575 | Artwohl M, Furnsinn C, Waldhausl W, Holzenbein T, Rainer G, Freudenthaler A, Roden M, Baumgartner-Parzer SM: Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPARgamma-independent mechanism. Diabetologia. 2005 Mar;48(3):586-94. Epub 2005 Feb 24. Proliferation, cell cycle distribution, protein expression, peroxisome proliferator-activated receptor responsive element (PPRE) transcriptional activity and mitochondrial effects were determined by [3H] incorporation, FACS analyses, western blots, reporter assays and lactate release respectively. Proliferation inhibition and lactate release were mimicked by rotenone (mitochondrial complex I inhibitor). |
1(0,0,0,1) | Details |
| 19772854 | Aronis A, Aharoni-Simon M, Madar Z, Tirosh O: Triacylglycerol-induced impairment in mitochondrial biogenesis and function in J774.2 and mouse peritoneal macrophage foam cells. Arch Biochem Biophys. 2009 Dec;492(1-2):74-81. Epub 2009 Sep 20. Inhibitors of mitochondrial complexes, rotenone (0.1 microM) and myxothiazol (25 nM), protected the viability in TG-loaded macrophages. Activation of peroxisome proliferator-activated receptors attenuated reactive species production in the foam cells. |
1(0,0,0,1) | Details |
| 17951219 | Sharifpanah F, Wartenberg M, Hannig M, Piper HM, Sauer H: Peroxisome proliferator-activated receptor alpha agonists enhance cardiomyogenesis of mouse ES cells by utilization of a reactive species-dependent mechanism. Stem Cells. 2008 Jan;26(1):64-71. Epub 2007 Oct 18. Treatment with PPARalpha, but not PPARbeta, and PPARgamma agonists and MK886, resulted in generation of reactive species (ROS), which was inhibited in the presence of the oxidase inhibitors diphenylen iodonium (DPI) and apocynin and the free radical scavengers and N-(2-mercapto-propionyl)- (NMPG), whereas the mitochondrial complex I inhibitor rotenone was without effects. |
8(0,0,0,8) | Details |