Protein Information

Name acetylcholine receptor (protein family or complex)
Synonyms Acetylcholine receptor; Acetylcholine receptors

Compound Information

Name cartap
CAS

Reference List

PubMed Abstract RScore(About this table)
12696952 Lee SJ, Tomizawa M, Casida JE: Nereistoxin and cartap neurotoxicity attributable to direct block of the insect nicotinic receptor/channel. J Agric Food Chem. 2003 Apr 23;51(9):2646-52.

However, NTX and cartap are equally potent, direct-acting, and competitive displacers of [(3) H] thienylcyclohexylpiperidine binding at the noncompetitive blocker (NCB) site of the Apis nicotinic acetylcholine receptor (nAChR)/channel.
81(1,1,1,1) Details
14709019 Lee SJ, Caboni P, Tomizawa M, Casida JE: Cartap hydrolysis relative to its action at the insect nicotinic channel. J Agric Food Chem. 2004 Jan 14;52(1):95-8.

Both cartap and NTX are ion channel blockers of the nicotinic acetylcholine receptor (nAChR).
6(0,0,1,1) Details
14608492 Raymond Delpech V, Ihara M, Coddou C, Matsuda K, Sattelle DB: Action of nereistoxin on recombinant neuronal nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes. Invert Neurosci. 2003 Nov;5(1):29-35. Epub 2003 Nov 8.

Its synthetic analogue, Cartap, was the first commercial insecticide based on a natural product.
2(0,0,0,2) Details
10828278 Liao JW, Kang JJ, Liu SH, Jeng CR, Cheng YW, Hu CM, Tsai SF, Wang SC, Pang VF: Effects of cartap on isolated mouse phrenic nerve diaphragm and its related mechanism. Toxicol Sci. 2000 Jun;55(2):453-9.

0(0,0,0,0) Details
19923012 Zhou S, Dong Q, Li S, Guo J, Wang X, Zhu G: Developmental toxicity of cartap on zebrafish embryos. . Aquat Toxicol. 2009 Dec 13;95(4):339-46. Epub 2009 Nov 1.

Cartap is a widely used insecticide which belongs to a member of nereistoxin derivatives and acts on nicotinic acetylcholine receptor site.
81(1,1,1,1) Details