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Tomigahara Y, Onogi M, Saito K, Isobe N, Kaneko H, Nakatsuka I: Metabolism of Cyanox in rat. Xenobiotica. 2000 Apr;30(4):395-406.
Oxidative desulphuration and oxidative dearylation, involving cytochrome P450 enzymes, were inhibited by male-specific rat CYP2C11 antiserum.
To examine the metabolites of Cyanox (O-4-cyanophenyl O,O-dimethyl phosphorothioate, cyanophos, CYAP) in brain, liver, blood cells and plasma during the early toxic period, the male and female rat was administered a single oral dose of [phenyl-14C] Cyanox at dose levels of 50 mg/kg and killed 5, 10 and 20 min thereafter. 2. |
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