Protein Information

Name chloride channel (protein family or complex)
Synonyms chloride channel

Compound Information

Name tetramethrin
CAS

Reference List

PubMed Abstract RScore(About this table)
17603033 Borg JJ, Hancox JC, Zhang H, Spencer CI, Li H, Kozlowski RZ: Differential pharmacology of the cardiac anionic background current I (AB). Eur J Pharmacol. 2007 Aug 27;569(3):163-70. Epub 2007 Jun 5.

This study investigated the effects of on I (AB) of four pyrethroid agents tefluthrin (a selective activator of this current), tetramethrin, fenpropathrin and alpha-cypermethrin in addition to other well known chloride channel modulators (chlorotoxin, gadolinium and picrotoxin).
31(0,1,1,1) Details
8597060 Narahashi T, Carter DB, Frey J, Ginsburg K, Hamilton BJ, Nagata K, Roy ML, Song JH, Tatebayashi H: Sodium channels and GABAA receptor-channel complex as targets of environmental toxicants. Toxicol Lett. 1995 Dec;82-83:239-45.

Voltage-activated sodium channels and GABAA receptor-chloride channel complex are among the most important target sites of various environmental neurotoxicants.
In rat cerebellar Purkinje neurons and dorsal root ganglion neurons, only about 1% of sodium channel population needed to be modified by the pyrethroid tetramethrin to increase the depolarizing after-potential to the level of the threshold membrane potential for generation of repetitive after-discharges.
2(0,0,0,2) Details