| Name | neurotoxic esterase |
|---|---|
| Synonyms | NTE; SWS; Neuropathy target esterase; Neurotoxic esterase; PNPLA 6; patatin like phospholipase domain containing 6; Neuropathy target esterases… |
| Name | leptophos |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 72768 | El-Sebae AH, Soliman SA, Elamayem MA, Ahmed NS: Neurotoxicity of organophosphorus insecticides Leptophos and EPN. J Environ Sci Health B. 1977;12(4):269-87. The results revealed that all five compounds were inhibitors of cholinesterase, but only Leptophos and EPN were shown to be potent inhibitors for both neurotoxic esterase and monoamine oxidase in the mouse brain. |
82(1,1,1,2) | Details |
| 6623496 | Reinders JH, Hansen LG, Metcalf RL: In vitro neurotoxic esterase assay using leptophos oxon analogs as inhibitors. Toxicol Lett. 1983 Jun;17(1-2):107-11. |
62(0,2,2,2) | Details |
| 9823777 | Tian Y, Xie XK, Piao FY, Yamauchi T: Delayed neuropathy and inhibition of soluble neuropathy target esterase following the administration of organophosphorus compounds to hens. Tohoku J Exp Med. 1998 Jul;185(3):161-71. Delayed neuropathy and inhibition of soluble neuropathy target esterase (NTE) and acetylcholinesterase (AChE) activities in different regions of brain and spinal cord of adult hens were studied after the intravenous administration of leptophos (30 mg/kg), tri-o-cresyl (TOCP 40 mg/kg) or dipterex (200 mg/kg). |
32(0,1,1,2) | Details |
| 2432215 | Soliman SA, Curley A, Farmer J, Novak R: In vivo inhibition of chicken brain acetylcholinesterase and neurotoxic esterase in relation to the delayed neurotoxicity of leptophos and cyanofenphos. J Environ Pathol Toxicol Oncol. 1986 Sep-Dec;7(1-2):211-24. |
32(0,1,1,2) | Details |
| 6084066 | Soliman SA, Farmer JD: Delayed neuropathy in adult Peking ducks induced by some organophosphorus esters. J Toxicol Environ Health. 1984;14(5-6):789-801. Biochemically, it was found that duck brain neurotoxic esterase (NTE) activity was inhibited in vivo to less than 15% of control levels as measured 24 h after the last treatment with TOCP, leptophos, or cyanofenphos. |
31(0,1,1,1) | Details |
| 2453943 | Farage-Elawar M, Francis BM: Effects of fenthion, fenitrothion and desbromoleptophos on gait, acetylcholinesterase, and neurotoxic esterase in young chicks after in ovo exposure. Toxicology. 1988 May;49(2-3):253-61. |
2(0,0,0,2) | Details |
| 3952739 | Schwab BW, Richardson RJ: Lymphocyte and brain neurotoxic esterase: dose and time dependence of inhibition in the hen examined with three organophosphorus esters. Toxicol Appl Pharmacol. 1986 Mar 30;83(1):1-9. Diethyl (paraoxon), tri-2-cresyl (TOCP), methyl 2,5-dichloro-4-bromophenyl phenylphosphonothionate (leptophos), and di-n-butyl-2,2-dichlorovinyl (di-n-butyl dichlorvos, DBDCV) were used to examine the relationship between lymphocyte and brain NTE inhibition in hens. |
2(0,0,0,2) | Details |
| 7278155 | Soliman SA, Curley A: Assay of chicken brain neurotoxic esterase activity using leptophosoxon as the selective inhibitor. J Anal Toxicol. 1981 Jul-Aug;5(4):183-6. The availability of leptophos/leptophosoxon makes this assay very useful for screening organophosphorus esters for effects. |
2(0,0,0,2) | Details |
| 10509429 | Abdelsalam EB: potential of six organophosphorus compounds in adult hens. Vet Hum Toxicol. 1999 Oct;41(5):290-2. The potential of trichlorfon, diazinon, phosmet, dichlorvos, phosphamidon and coumaphos was evaluated for their ability to inhibit brain neurotoxic esterase (NTE) activity in adult hens. Leptophos was used as a reference agent. |
1(0,0,0,1) | Details |
| 6169754 | El-Sebae AH, Soliman SA, Ahmed NS, Curley A: Biochemical interaction of six OP delayed neurotoxicants with several neurotargets. J Environ Sci Health B. 1981;16(4):465-74. Five organophosphorous insecticides: Leptophos, EPN, Cyanofenphos, trichloronate and salithion proved to cause irreversible ataxia not only to chicken but also to mice and sheep. The six compounds and their oxons were screened for their in-vitro inhibition to monamine oxidase (MAO), acetyl cholinesterase (AChE) and neurotoxic esterase (NTE) in the brain of either mouse, lamb or chicken. |
1(0,0,0,1) | Details |
| 2449534 | Farage-Elawar M, Francis BM: Effects of multiple dosing of fenthion, fenitrothion, and desbromoleptophos in young chicks. J Toxicol Environ Health. 1988;23(2):217-28. The effects of multiple doses of desbromoleptophos, fenitrothion, and pure fenthion on brain acetylcholinesterase (AChE), brain neurotoxic esterase (NTE), and walking were investigated in immature chicks, below the age of sensitivity to organophosphorus ester-induced delayed neurotoxicity (OPIDN). |
1(0,0,0,1) | Details |
| 6205472 | Hoffman DJ, Sileo L, Murray HC: Subchronic organophosphorus ester-induced delayed neurotoxicity in mallards. Toxicol Appl Pharmacol. 1984 Aug;75(1):128-36. Brain neurotoxic esterase activity was inhibited by averages of 16, 69, 73, and 74% in the 10-, 30-, 90-, and 270-ppm groups, respectively. Additional ducks were exposed in a similar manner to 60-, 270-, or 540-ppm leptophos (phosphonothioic acid O-4-bromo-2,5-dichlorophenyl-O-methylphenyl ester) which resulted in similar behavioral, biochemical, and histopathological alterations. |
1(0,0,0,1) | Details |
| 8511793 | Veronesi B, Ehrich M: Differential cytotoxic sensitivity in mouse and human cell lines exposed to organophosphate insecticides. Toxicol Appl Pharmacol. 1993 Jun;120(2):240-6. Baseline activities of the major target esterases, i.e., cholinesterase, carboxylesterase, and neurotoxic esterase, were assayed in mouse and several human neural candidate cell lines. IC50 data indicated that the tested mouse cell line was consistently more sensitive than the human cell line to equimolar doses of various OP compounds (e.g., mipafox, parathion, paraoxon, DFP, leptophos oxon, fenthion, and fenitrothion). |
1(0,0,0,1) | Details |
| 438464 | El-Sebae AH, Soliman SA, Ahmed NS: Delayed neuropathy in sheep by the phosphonothioate insecticide cyanofenphos. J Environ Sci Health B. 1979;14(3):247-63. In brain samples from ataxiated animals, AChE, MAO and NTE (neurotoxic esterase) activities were assayed simultaneously with untreated animal. |
1(0,0,0,1) | Details |
| 6192547 | Soliman SA, Svendsgaard D, Farmer JD, Curley A, Durham WF: Six-month daily treatment of sheep with organophosphorus compounds. Toxicol Appl Pharmacol. 1983 Jul;69(3):417-31. The delayed effects of tri-o-cresyl- (TOCP), O-methyl-O-(4-bromo-2,5-dichlorophenyl) phenylphosphonothioate (leptophos), and O-ethyl O- phenylphosphonothioate (EPN) at 5, 5, and 1 mg/kg/day, respectively, on male sheep were studied during 6 months of daily oral treatment under field conditions. These clinical results were supported by histological findings and also by biochemical results with neurotoxic esterase (NTE) measurements. |
1(0,0,0,1) | Details |
| 2439699 | Farage-Elawar M, Francis BM: Acute and delayed effects of fenthion in young chicks. J Toxicol Environ Health. 1987;21(4):455-69. The effects of desbromoleptophos, fenitrothion, and fenthion on brain acetylcholinesterase (AChE), brain neurotoxic esterase (NTE), and walking were investigated in immature chicks, below the age of organophosphorus ester-induced delayed neurotoxicity (OPIDN). |
1(0,0,0,1) | Details |
| 10321902 | Barber D, Correll L, Ehrich M: Comparative effectiveness of organophosphorus protoxicant activating systems in neuroblastoma cells and brain homogenates. J Toxicol Environ Health A. 1999 May 14;57(1):63-74. The ability of and rat liver microsomes (RLM) to convert organophosphorus (OP) protoxicants to esterase inhibitors was determined by measuring acetylcholinesterase (AChE) and neuropathy target esterase (NTE) inhibition. OP protoxicants examined included tri-o-tolyl (TOTP), O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN), leptophos, fenitrothion, fenthion, and malathion. |
1(0,0,0,1) | Details |
| 89138 | Hussain MA, Oloffs PC: effects of leptophos (PhosvelR) in chickens and rats following chronic low-level feeding. J Environ Sci Health B. 1979;14(4):367-82. In the paralysed hens, 79% of the neurotoxic esterase in the brain were inhibited, whereas in the non-paralysed hens (including the one non-paralysed hen receiving 5.0 mg/kg/day) and all rats only about half as much was inhibited. |
1(0,0,0,1) | Details |
| 12638169 | Konno N: [Neurotoxicity of organophosphorus and dithiocarbamate compounds] . Nippon Eiseigaku Zasshi. 2003 Jan;57(4):645-54. The neurotoxicity of organophosphorus compounds (OPs) including leptophos, TOCP and triphenyl and dithiocarbamate compounds were reviewed in this study. |
0(0,0,0,0) | Details |
| 2462700 | Cherniack MG: Toxicological screening for organophosphorus-induced delayed neurotoxicity: complications in toxicity testing. Neurotoxicology. 1988 Summer;9(2):249-71. These were leptophos, fenthion, and isofenphos. |
0(0,0,0,0) | Details |