| Name | estrogen receptors |
|---|---|
| Synonyms | ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA… |
| Name | HCH |
|---|---|
| CAS | 1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15253041 | Okubo T, Yokoyama Y, Kano K, Soya Y, Kano I: Estimation of estrogenic and antiestrogenic activities of selected pesticides by MCF-7 cell proliferation assay. Arch Environ Contam Toxicol. 2004 May;46(4):445-53. Estrogenic activities of 20 selected pesticides-which are used for agricultural production as insecticides, fungicides and herbicides-were examined by estrogen receptor (ER)-dependent MCF-7 cell proliferation assay. |
6(0,0,0,6) | Details |
| 18992306 | Li J, Li N, Ma M, Giesy JP, Wang Z: In vitro profiling of the endocrine disrupting potency of organochlorine pesticides. Toxicol Lett. 2008 Dec 15;183(1-3):65-71. Epub 2008 Oct 17. Aspects of neuro-endocrine system modulation include interactions such as agonism or antagonism of estrogen receptor (ER) binding. |
3(0,0,0,3) | Details |
| 12948864 | Zou E, Matsumura F: Long-term exposure to beta-hexachlorocyclohexane (beta-HCH) promotes transformation and invasiveness of MCF-7 human breast cancer cells. Biochem Pharmacol. 2003 Sep 1;66(5):831-40. Additionally, beta-HCH has recently been identified as an environmental capable of activating estrogen receptor (ER) through a ligand-independent pathway. |
2(0,0,0,2) | Details |
| 20206645 | Silva E, Kabil A, Kortenkamp A: Cross-talk between non-genomic and genomic signalling pathways - Distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Mar 4. Estrogen receptor (ER) transcriptional cross-talk after activation by 17beta- (E2) has been studied in considerable detail, but comparatively little is known about the ways in which synthetic -like chemicals, so-called xenoestrogens, interfere with these signalling pathways. |
2(0,0,0,2) | Details |
| 16242299 | Wong PS, Matsumura F: Serum free BG-1 cell proliferation assay: a sensitive method for determining organochlorine pesticide estrogen receptor activation at the nanomolar range. Toxicol In Vitro. 2006 Apr;20(3):382-94. Epub 2005 Oct 19. |
2(0,0,0,2) | Details |
| 11872169 | Lee HS, Miyauchi K, Nagata Y, Fukuda R, Sasagawa S, Endoh H, Kato S, Horiuchi H, Takagi M, Ohta A: Employment of the human estrogen receptor beta ligand-binding domain and co-activator SRC1 nuclear receptor-binding domain for the construction of a yeast two-hybrid detection system for endocrine disrupters. J Biochem. 2002 Mar;131(3):399-405. We constructed two-hybrid systems that co-express the Gal4p DNA binding domain/ligand-binding domain of human estrogen receptor (hER) alpha or beta and the Gal4p transactivation domain/nuclear receptor-binding domain of co-activator SRC1, TIF2, or AIB1 in Saccharomyces cerevisiae with a chromosome-integrated lacZ reporter gene under the control of Gal4p-binding sites. |
2(0,0,0,2) | Details |
| 9872718 | Celius T, Haugen TB, Grotmol T, Walther BT: A sensitive zonagenetic assay for rapid in vitro assessment of estrogenic potency of xenobiotics and mycotoxins. Environ Health Perspect. 1999 Jan;107(1):63-8. When cells were treated with xenoestrogens or mycotoxins in combination with an estrogen receptor inhibitor (ICI 182,780), the induction of both zr proteins and vitellogenin was inhibited in all cases. |
1(0,0,0,1) | Details |
| 10580743 | Maruyama S, Fujimoto N, Yin H, Ito A: Growth stimulation of a rat pituitary cell line MtT/E-2 by environmental estrogens in vitro and in vivo. Endocr J. 1999 Aug;46(4):513-20. Binding assays showed the test chemicals were able to compete with 3H-E2 binding to the estrogen receptor (ER). |
1(0,0,0,1) | Details |
| 11411516 | Kobayashi S, Sugaya T, Sakata N, Uebayasi M, Sameshima K, Tanaka A: Prediction of endocrine disruptors based on a new structure-activity relationship for sex and environmental hormones using chemical hardness concept. Chem Pharm Bull. 2001 Jun;49(6):680-8. For instance, 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) is classified in group II, therefore, it would bind with the thyroid receptor more than the estrogen receptor (group I). |
1(0,0,0,1) | Details |
| 2479123 | Coosen R, van Velsen FL: Effects of the beta-isomer of hexachlorocyclohexane on -sensitive human mammary tumor cells. Toxicol Appl Pharmacol. 1989 Nov;101(2):310-8. The effects of the beta-isomer of hexachlorocyclohexane (beta-HCH) on the induction of the cytosolic progesterone receptor (PgRc), on the redistribution of the estrogen receptor (ER), and its affinity for ER were investigated in the -sensitive human mammary tumor cell line MCF-7. |
1(0,0,0,1) | Details |
| 17537412 | Maranghi F, Rescia M, Macri C, Di Consiglio E, De Angelis G, Testai E, Farini D, De Felici M, Lorenzetti S, Mantovani A: Lindane may modulate the female reproductive development through the interaction with ER-beta: an in vivo-in vitro approach. Chem Biol Interact. 2007 Aug 15;169(1):1-14. Epub 2007 Apr 22. Since both estrogen receptors (ER-alpha and -beta) have shown to be target for endocrine disruption, we investigated the role of gamma-HCH on the development of female reproductive system. |
1(0,0,0,1) | Details |
| 8783812 | Tiemann U, Schneider F, Tuchscherer A: Effects of organochlorine pesticides on DNA synthesis of cultured oviductal and uterine cells and on estrogen receptor of uterine tissue from heifers. Arch Toxicol. 1996;70(8):490-6. |
1(0,0,0,1) | Details |
| 7524197 | Laws SC, Carey SA, Hart DW, Cooper RL: Lindane does not alter the estrogen receptor or the -dependent induction of progesterone receptors in sexually immature or ovariectomized adult rats. Toxicology. 1994 Sep 6;92(1-3):127-42. It has been suggested that gamma-HCH may block the response of -dependent tissues to via an interaction with the estrogen receptor. |
1(0,0,0,1) | Details |
| 17640349 | Wong PS, Matsumura F: Promotion of breast cancer by beta-hexachlorocyclohexane in MCF10AT1 cells and MMTV-neu mice. BMC Cancer. 2007 Jul 17;7:130. Previous studies in our laboratory have demonstrated the ability of beta-HCH to elicit its actions via a ligand-independent activation of the estrogen receptor through increased c-Neu (= erbB2 or HER-2) expression and kinase activation in both the BG-1 and MCF-7 cell lines. |
1(0,0,0,1) | Details |
| 8968093 | Steinmetz R, Young PC, Caperell-Grant A, Gize EA, Madhukar BV, Ben-Jonathan N, Bigsby RM: Novel estrogenic action of the pesticide residue beta-hexachlorocyclohexane in human breast cancer cells. Cancer Res. 1996 Dec 1;56(23):5403-9. The prototypical xenoestrogen o,p'-dichlorodiphenyltrichloroethane (o,p'-DDT) acts by binding and activating the estrogen receptor (ER). |
1(0,0,0,1) | Details |