| Name | demethylase |
|---|---|
| Synonyms | DMTase; Demethylase; MBD 2; MBD2; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; NY CO 41; Demethylases… |
| Name | aldrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9622849 | McKillop D, Butters CJ, Hill SJ, Simons PJ, Edwards TL, Doughty SE: Enzyme-inducing effects of bicalutamide in mouse, rat and dog. Xenobiotica. 1998 May;28(5):465-78. Bicalutamide, a non-steroidal antiandrogen, produced dose-related increases in total cytochrome P450 (P450) and aldrin epoxidase, but had no effect on ethoxyresorufin O-deethylase, when administered for 10 weeks at 0, 25, 75 and 150 mg/kg/day to the male dog. 2. Bicalutamide, administered as 14 daily oral doses (250 mg/kg) to groups of male rats, produced increases primarily in ethoxycoumarin O-deethylase and erythromycin N-demethylase, together with smaller increases in ethoxyresorufin O-deethylase and pentoxyresorufin O-dealkylase; these changes were reversible within 7 days. |
1(0,0,0,1) | Details |
| 9169061 | Elliott JE, Kennedy SW, Lorenzen A: Comparative toxicity of polychlorinated biphenyls to Japanese quail (Coturnix c. japonica) and American kestrels (Falco sparverius). J Toxicol Environ Health. 1997 May;51(1):57-75. APND and aldrin epoxidase (AE) were induced; EROD was not induced, although a hepatic CYP1A-like protein was detected in 1 kestrel dosed for 12 wk. In quail, an acute dose of Aroclor 1254 caused significant liver weight increases, hepatic and renal EROD and aminopyrine n-demethylase (APND) induction, and dose-related hepatic and renal porphyria. |
1(0,0,0,1) | Details |
| 4036165 | Murray M, Hetnarski K, Wilkinson CF: Selective inhibitory interactions of alkoxymethylenedioxybenzenes towards mono-oxygenase activity in rat-hepatic microsomes. Xenobiotica. 1985 May;15(5):369-79. Ethoxyresorufin O-deethylase in Beta NF-induced microsomes and aminopyrine N-demethylase in PB-induced microsomes were most susceptible to inhibition by the test compounds. In contrast, aldrin epoxidation and arylhydrocarbon hydroxylase in PB-and Beta NF-induced microsomes, respectively, were not inhibited by derivatives of AMDB. |
1(0,0,0,1) | Details |
| 3705083 | Sawyer T, Jones D, Rosanoff K, Mason G, Piskorska-Pliszczynska J, Safe S: The biologic and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in chickens. Toxicology. 1986 May;39(2):197-206. Incubation of the 2,3,7,8-TCDD-induced microsomes with SKF-525A and alpha-naphthoflavone showed that both compounds inhibited N-demethylase, EROD and AHH and that alpha-naphthoflavone was the more potent inhibitor of all 3 microsomal monooxygenases. 2,3,7,8-TCDD treatment caused significant involution of the Bursa of Fabricius when administered at a dose level of 10 micrograms/kg for 3 days and this result confirmed the extreme sensitivity of the immature White Leghorn cockerel to the biologic and toxic effects elicited by 2,3,7,8-TCDD. |
1(0,0,0,1) | Details |
| 2426844 | Trela BA, Carlson GP, Chadwick RW, Copeland MF: A comparison of in vitro and in vivo methods for evaluating alterations in hepatic drug metabolism following mercuric administration. Toxicol Lett. 1986 Jul-Aug;32(1-2):133-40. The activities of ethylmorphine demethylase, hexobarbital oxidase and aldrin epoxidase determined in vitro were not inhibited by mercuric although hydroxylase activity was decreased. |
0(0,0,0,0) | Details |
| 3818484 | Wisniewski JA, Moody DE, Hammock BD, Shull LR: Interlobular distribution of hepatic xenobiotic-metabolizing enzyme activities in cattle, goats and sheep. J Anim Sci. 1987 Jan;64(1):210-5. Within individual species, concentrations of cytochrome P-450 and b5 and activities of cytochrome c reductase, aldrin epoxidase, aminopyrine N-demethylase, ethoxycoumarin O-deethylase, microsomal and cytosolic stilbene oxide (epoxide) hydrolase and glutathione S-transferase were not different (P greater than .05) among the various hepatic lobes. |
0(0,0,0,0) | Details |
| 10985040 | Valles SM, Oi FM, Wagner T, Brenner RJ: Toxicity and in vitro metabolism of t-permethrin in eastern subterranean termite (Isoptera: Rhinotermitidae). J Econ Entomol. 2000 Aug;93(4):1259-64. Despite these differences in t-permethrin susceptibility, microsomal oxidase activities toward surrogate substrate (aldrin epoxidase, and methoxyresorufin O-demethylase), cytochrome P450 content, and microsomal esterase activity toward alpha-naphthyl did not differ significantly between the colonies. |
0(0,0,0,0) | Details |
| 11976062 | Valles SM, Woodson WD: Insecticide susceptibility and detoxication enzyme activities among Coptotermes formosanus Shiraki workers sampled from different locations in New Orleans. Comp Biochem Physiol C Toxicol Pharmacol. 2002 Apr;131(4):469-76. As with the bioassay data, although significant differences were noted, a great deal of overlap was observed among the colonies for total cytochrome P450 content (difference of 2.2-fold between high and low value) aldrin epoxidation (3.6-fold) and cytosolic esterase (3.9-fold) activity. |
0(0,0,0,0) | Details |
| 6603386 | Meier PJ, Mueller HK, Dick B, Meyer UA: Hepatic monooxygenase activities in subjects with a genetic defect in drug oxidation. Gastroenterology. 1983 Sep;85(3):682-92. There was no correlation between the capacity for debrisoquine hydroxylation and the total concentration of microsomal cytochrome P450, cytochrome b5, or the activities of -cytochrome c reductase, aminopyrine-N-demethylase, aryl hydrocarbon hydroxylase, ethoxycoumarin-O-deethylase, aldrin epoxidase, and 2-biphenylhydroxylase. |
0(0,0,0,0) | Details |
| 3390215 | Leslie C, Reidy GF, Murray M, Stacey NH: Induction of xenobiotic biotransformation by the insecticide chlordimeform, a metabolite 4-chloro-o-toluidine and a structurally related chemical o-toluidine. Biochem Pharmacol. 1988 Jul 1;37(13):2529-35. Chlordimeform had no effect on the cytochrome P-450 content, p-hydroxylase or glutathione S-transferase activities, but induced ethoxyresorufin-O-deethylase, ethoxycoumarin-O-deethylase and epoxide hydrolase activities and decreased aldrin epoxidase and aminopyrine N-demethylase activities. |
0(0,0,0,0) | Details |
| 2873991 | Beaune PH, Kremers PG, Kaminsky LS, De Graeve J, Albert A, Guengerich FP: Comparison of monooxygenase activities and cytochrome P-450 isozyme concentrations in human liver microsomes. Drug Metab Dispos. 1986 Jul-Aug;14(4):437-42. The results of correlation analysis suggest that: there are important variations in the amounts of the three cytochrome P-450 isozymes measured, particularly P-450 (8) and P-450 (9); aldrin epoxidase, d-benzphetamine N-demethylase, and S- 4-hydroxylase activities are linked to cytochrome P-450 (5); aryl hydrocarbon (benzo (a) pyrene) hydroxylase and 4-nitroanisole-O-demethylase activities are linked to P-450 (8); hydroxylations at the 4'-, 6-, 7-, and 8-positions of R- are closely linked to each other but are not correlated with other measured monooxygenase activities or P-450 isozyme levels; and P-450 (9) is not related to any of the catalytic activities tested. |
0(0,0,0,0) | Details |
| 2386543 | Matthew DE, Houston JB: Drug metabolizing capacity in vitro and in vivo--I. Biochem Pharmacol. 1990 Aug 15;40(4):743-9. No trends were observed with the formation clearance of 3-hydroxymethylantipyrine and 7-methoxycoumarin O-demethylase whilst a negative response was observed with aldrin epoxidase. |
0(0,0,0,0) | Details |
| 3107167 | Azais V, Arand M, Rauch P, Schramm H, Bellenand P, Narbonne JF, Oesch F, Pascal G, Robertson LW: A time-course investigation of levels and drug metabolizing enzyme activities in rats following a single treatment with prototypic polychlorinated biphenyls and DDT. Toxicology. 1987 Jun;44(3):341-54. Although 3,3',4,4'-tetrachlorobiphenyl specifically induced certain drug-metabolizing enzyme activities, e.g. aryl hydrocarbon hydroxylase and UDP-glucuronosyltransferase (toward no highly significant correlations were found among the levels and drug-metabolizing enzyme activities in the liver (aminopyrine N-demethylase, aryl hydrocarbon hydroxylase, aldrin epoxidase, microsomal epoxide hydrolase, UDP-glucuronosyltransferase toward glutathione transferase toward 1-chloro-2,4-dinitrobenzene and cytochrome P-450 content) as determined by multiple linear regression analysis. |
0(0,0,0,0) | Details |
| 3002389 | Denomme MA, Leece B, Li A, Towner R, Safe S: Elevation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) polychlorinated biphenyls. Biochem Pharmacol. 1986 Jan 15;35(2):277-82. There was no correlation between increased levels of hepatic receptor protein and the induction of the cytochrome P-450-dependent monooxygenases, aldrin epoxidase or 4-dimethylaminoantipyrine N-demethylase. |
0(0,0,0,0) | Details |
| 2425856 | Gutkina NI, Mishin VM, Liakhovich VV: [Induction of the phenobarbital form of cytochrome P-450 by chemically unrelated compounds]. Biokhimiia. 1986 Jul;51(7):1223-9. Antibodies against PB-cytochrome P-450 inhibited by 50-70% the benzphetamine-N-demethylase and aldrin-epoxidase activities, whereas the antibodies to methylcholanthrene-induced cytochrome P-450 were fairly ineffective. |
37(0,1,2,2) | Details |
| 3663750 | Grishanova AIu, Obraztsov VV, Shekhtman DG, Liakhovich VV: [Phenobarbital-type induction of cytochrome P-450 in liver microsomes by perfluorodecalin]. Biokhimiia. 1987 Jul;52(7):1138-43. The activity of benzphetamine demethylase and aldrin epoxidase was inhibited by antibodies against cytochrome P-450b. |
31(0,1,1,1) | Details |
| 2386544 | Matthew DE, Houston JB: Drug metabolizing capacity in vitro and in vivo--II. Biochem Pharmacol. 1990 Aug 15;40(4):751-8. The in vivo clearance of (TOL), (TH), antipyrine (AP) and its metabolites were determined in the same rats used for hepatic microsome preparation and assessment of P450 content and activities (via 7-ethoxycoumarin O-deethylase (ECOD), 7 ethoxyresorufin O-deethylase, 7-methoxycoumarin O-demethylase (MCOD) and aldrin epoxidase determinations). |
31(0,1,1,1) | Details |
| 2411555 | Cresteil T, Beaune P, Kremers P, Celier C, Guengerich FP, Leroux JP: Immunoquantification of epoxide hydrolase and cytochrome P-450 isozymes in fetal and adult human liver microsomes. Eur J Biochem. 1985 Sep 2;151(2):345-50. Aldrin epoxidase and benzphetamine-N-demethylase activities were correlated with isozyme 5 concentration, but with different slopes for adult and fetal microsomes: adult preparations catalyzed these two reactions more efficiently. |
31(0,1,1,1) | Details |
| 6414484 | Denomme MA, Bandiera S, Lambert I, Copp L, Safe L, Safe S: Polychlorinated biphenyls as phenobarbitone-type inducers of microsomal enzymes. Biochem Pharmacol. 1983 Oct 1;32(19):2955-63. This study examines the effects of structure on the activity of a series of 2,4-dichloro-substituted biphenyls as inducers of several microsomal enzyme activities including dimethylaminoantipyrine N-demethylase, benzo [a] pyrene hydroxylase, aldrin epoxidase, and ethoxyresorufin O-deethylase. |
12(0,0,2,2) | Details |
| 2725470 | Lorr NA, Bloom SE, Park SS, Gelboin HV, Miller H, Friedman FK: Evidence for a PCN-P450 enzyme in chickens and comparison of its development with that of other phenobarbital-inducible forms. Mol Pharmacol. 1989 May;35(5):610-6. Chicken liver microsomal erythromycin demethylase, a characteristic activity of rat -16-alpha-carbonitrile-inducible P450, was similar in developmental profile and induction to the immunodetected protein, with a high degree of augmentation at 1 day posthatch compared with that in the embryo and at 36 days posthatch; aldrin epoxidase, benzphetamine demethylase, ethylmorphine demethylase, and aminopyrine demethylase were more similar to each other in development and induction and were less well correlated with the immunodetected protein. |
7(0,0,1,2) | Details |
| 6640429 | Denomme MA, Leece B, Gyorkos J, Homonko K, Safe S: Polychlorinated and congeners as inducers of rat hepatic drug-metabolizing enzymes in immature male Wistar rats. Can J Physiol Pharmacol. 1983 Sep;61(9):1063-70. Hexachlorobenzene induced N-demethylase and aldrin epoxidase, two PB-inducible enzymes, and benzo [a] pyrene hydroxylase and ethoxyresorufin O-deethylase, two enzymes induced by 3-methylcholanthrene (MC). |
7(0,0,1,2) | Details |
| 6744234 | Siegers CP, Schumann S, Thies E, Bose-Younes H, Younes M: Aldrin epoxidase and dimethylhydrazine demethylase activities in tumorous and non-tumorous tissue of the human colon and rectum. Cancer Lett. 1984 May;23(1):39-43. |
12(0,0,2,2) | Details |
| 2619326 | Leslie C, Reidy GF, Stacey NH: Effect of ofurace, oxadixyl, and alachlor on xenobiotic biotransformation in the rat liver. Arch Environ Contam Toxicol. 1989 Nov;18(6):876-80. Glutathione S-transferase and aminopyrine N-demethylase activities responded in a non dose-dependent manner, while cytochrome P-450 content and aldrin epoxidase activities were unchanged. |
7(0,0,1,2) | Details |
| 3190755 | Leslie C, Reidy GF, Stacey NH: The effects of propiconazole on hepatic xenobiotic biotransformation in the rat. Biochem Pharmacol. 1988 Nov 1;37(21):4177-81. Induction was seen for cytochrome P-450, ethoxyresorufin-O-deethylase, ethoxycoumarin-O-deethylase, aldrin epoxidase, aminopyrine N-demethylase and microsomal expoxide hydrolase activities. |
7(0,0,1,2) | Details |
| 20050562 | Xiao NW, Liu XH, Li W, Ge F: Effect of herbicide acetochlor on cytochrome P450 monooxygenases and GST of earthworms Eisenia fetida. J Environ Sci. 2006;18(1):135-40. Effects of the acetochlor on cytochrome P450 monooxygenases p-nitroanisole O-demethylase (ODM), aldrin epoxidase (AE) and glutathione-S-transferases (GSTs) activities were determined. |
6(0,0,1,1) | Details |
| 3927658 | Schoket B, Vincze I: Induction of rat hepatic drug metabolizing enzymes by substituted urea herbicides. Acta Pharmacol Toxicol. 1985 Apr;56(4):283-8. Aldrin epoxidase activities were increased up to 3-fold, and aminopyrine N-demethylase activities were only slightly different from the control level. |
6(0,0,1,1) | Details |
| 107617 | Riviere JL, De Lavaur E, Grolleau G: Effect of polychlorinated biphenyls on drug metabolism in Japanese quail and its progeny. Toxicology. 1978 Dec;11(4):329-34. PCB (DP5, 1 and 5 mg/female/day, orally for 40 days) induce microsomal hepatic enzymes (cytochrome P-450, hydroxylase, aldrin epoxidase, p-nitroanisole demethylase, UDPGA-transferase) in adult female Japanese quail. |
6(0,0,1,1) | Details |
| 2495802 | Puttmann M, Mannschreck A, Oesch F, Robertson L: Chiral effects in the induction of drug-metabolizing enzymes using synthetic atropisomers of polychlorinated biphenyls (PCBs). Biochem Pharmacol. 1989 Apr 15;38(8):1345-52. The racemic hexachlorobiphenyl (II) was found to be a potent (phenobarbital-type) inducer, whereas (+)-II and (-)-II, administered at 100 mumol/kg, showed clearly differing potencies as inducers with (+)-II enhancing aminopyrine N-demethylase, aldrin epoxidase and cytochrome P-450 content more potently than (-)-II. |
6(0,0,1,1) | Details |
| 2508517 | Banton MI, Flory W, Jowett PL, Winston GW: Comparison of the effects of Sesbania drummondii on the hepatic microsomal monooxygenase systems of chickens and rats. Am J Vet Res. 1989 Oct;50(10):1795-9. Increases of twofold in the cytochrome P-450 content, -cytochrome c-reductase, aminopyrine-N-demethylase, hydroxylase, ethoxycoumarin-O-deethylase, and aryl hydrocarbon hydroxylase activities; fourfold in the aldrin epoxidase activity; and 15-fold in the ethoxyresorufin-O-deethylase activity were observed in the S drummondii-treated chickens. |
6(0,0,1,1) | Details |
| 6618147 | Campbell MA, Gyorkos J, Leece B, Homonko K, Safe S: The effects of twenty-two organochlorine pesticides as inducers of the hepatic drug-metabolizing enzymes. Gen Pharmacol. 1983;14(4):445-54. With the exception of HCB, all of the pesticides induced microsomal dimethylaminoantipyrine, N-demethylase and aldrin epoxidase activities and the cytochrome P-450 content of microsomes from animals pretreated with most of the compounds was also increased compared to control rats. |
6(0,0,1,1) | Details |
| 4052094 | Kelley M, Lambert I, Merrill J, Safe S: 1,4-Bis [2-(3,5-dichloropyridyloxy)] (TCPOBOP) and related compounds as inducers of hepatic monooxygenases. Biochem Pharmacol. 1985 Oct 1;34(19):3489-94. Dose-response induction of mice hepatic microsomal cytochrome P-450, aldrin epoxidase and dimethylaminoantipyrine N-demethylase gave ED50 values for TCPOBOP and five homologs. |
6(0,0,1,1) | Details |
| 2890477 | Peakall DB, Jeffrey DA, Boersma D: Mixed-function oxidase activity in seabirds and its relationship to oil pollution. Comp Biochem Physiol C. 1987;88(1):151-4. The hepatic activity of epoxide hydrolase, aldrin epoxidase, aminopyrine N-demethylase, 7-ethoxyresorufin O-deethylase, benzo (a) pyrene 3-hydroxylase and UDP glucuronyl transferase was determined in adult herring gulls (Larus argentatus) at various stages of the breeding season. 2. |
6(0,0,1,1) | Details |
| 817422 | Vainio H, Parkki MG: Enhancement of microsomal monooxygenase, epoxide hydrase and UDPglucuronyltransferase by aldrin, dieldrin and isosafrole administrations in rat liver. Toxicology. 1976 Mar;5(3):279-86. All the compounds studied were found to enhance the activities of microsomal monooxygenase (e.g. p-nitroanisole O-demethylase, aryl hydrocarbon hydroxylase), epoxide hydrase (styrene oxide as substrate) and UDPglucuronyltransferase as aglycone). |
3(0,0,0,3) | Details |
| 6814016 | Fisher CW, Mayer RT: Characterization of house fly microsomal mixed function oxidases: inhibition by juvenile hormone i and piperonyl butoxide. Toxicology. 1982;24(1):15-31. The microsomal mixed function oxidase system of the house fly (Musca domestica [L.]) was characterized with respect to N-demethylation of p-chloromethylaniline, O-demethylation of methoxyresorufin, epoxidation of aldrin and the formation of a metabolite-cytochrome P-450 complex during oxidation of piperonyl butoxide (PB). The inhibition of these reactions by juvenile hormone I (E, E cis methyl 10,11-epoxy-7-ethyl-3, 11-dimethyl-2, 6-tridecadienoate, JH-I) was competitive for the N-demethylase, epoxidase and the formation of the PB metabolite-complex. |
2(0,0,0,2) | Details |
| 2510947 | Mishin VM, Obraztsov VV, Grishanova AYu, Gutkina NI, Shekhtman DG, Khatsenko OG, Lyakhovich VV: The phenobarbital-type induction of rat liver microsomal monooxygenases by perfluorodecalin. Chem Biol Interact. 1989;72(1-2):143-55. Like PB, PFD induces the activities of benzphetamine-N-demethylase, aldrine-epoxidase, 16 beta-androstendion-hydroxylase. |
1(0,0,0,1) | Details |
| 4063404 | Guliaeva LF, Mishin VM, Liakhovich VV: [Induction of cytochrome P-450 forms in liver microsomes of rats in the early neonatal period after administration of phenobarbital and 3-methylcholanthrene]. Biokhimiia. 1985 Nov;50(11):1817-24. In parallel, in the case of 3-methylcholantrene induction the benz (a) pyrene hydroxylase and 7-ethoxyresorufin deethylase activities increase; phenobarbital induction causes a rise in the benzphetamine-N-demethylase and benz (a) pyrene hydroxylase activities. The participation of phenobarbital-induced cytochrome P-450 in the metabolism of benzphetamine and aldrin in neonatal rats is much lower than in the adult ones. |
1(0,0,0,1) | Details |