Protein Information

Name chloride channel (protein family or complex)
Synonyms chloride channel

Compound Information

Name aldrin
CAS

Reference List

PubMed Abstract RScore(About this table)
1664255 Esser T, Karu AE, Toia RF, Casida JE: Recognition of tetramethylenedisulfotetramine and related sulfamides by the brain GABA-gated chloride channel and a cyclodiene-sensitive monoclonal antibody. Chem Res Toxicol. 1991 Mar-Apr;4(2):162-7.

Aldrin and many other cyclodiene and polychlorocycloalkane insecticides interact with both the [35S]-tert-butylbicyclophosphorothionate ([35S] TBPS) binding site of the mammalian brain gamma-aminobutyric acid (GABA) gated chloride channel and several cyclodiene monoclonal antibodies (MAbs) at concentrations ranging from 0.06 to 8.7 microM.
82(1,1,1,2) Details
6204183 Lawrence LJ, Casida JE: Interactions of lindane, toxaphene and cyclodienes with brain-specific t-butylbicyclophosphorothionate receptor. Life Sci. 1984 Jul 9;35(2):171-8.

Three major classes of chlorinated hydrocarbon insecticides, i.e., the lindane/hexachlorocyclohexane, toxaphene and aldrin/dieldrin types, are potent, competitive, and stereospecific inhibitors of t-butylbicyclophosphorothionate (TBPS) binding to brain-specific sites, thereby indicating an action at the gamma-aminobutyric acid (GABA)-regulated chloride channel.
81(1,1,1,1) Details