Protein Information

Name estrogen related receptor alpha
Synonyms ERR alpha; ERR 1; ERR1; ERRa; ERRalpha; ESRL 1; ESRL1; ESRRA…

Compound Information

Name chlordane
CAS

Reference List

PubMed Abstract RScore(About this table)
16515477 Ariazi EA, Jordan VC: Estrogen-related receptors as emerging targets in cancer and metabolic disorders. Curr Top Med Chem. 2006;6(3):203-15.

The organochlorine pesticides toxaphene and chlordane, and the synthetic compound XCT790 antagonize ERRalpha.
84(1,1,1,4) Details
20351196 Miao L, Shi J, Wang CY, Zhu Y, Du X, Jiao H, Mo Z, Klocker H, Lee C, Zhang J: Estrogen Receptor-Related Receptor {alpha} Mediates Up-Regulation of Aromatase Expression by Prostaglandin E2 in Prostate Stromal Cells. Mol Endocrinol. 2010 Mar 29.

Estrogen receptor-related receptor alpha (ERRalpha) is an orphan member of the nuclear receptor superfamily of transcription factors.
Suppression of ERRalpha activity by chlordane (an antagonist of ERRalpha) or small interfering RNA knockdown of ERRalpha blocked the increase of expression and promoter activity of aromatase induced by PGE2.
9(0,0,0,9) Details
18646811 Jin KS, Park JK, Yoon J, Rho Y, Kim JH, Kim EE, Ree M: Small-angle X-ray scattering studies on structures of an estrogen-related receptor alpha ligand binding domain and its complexes with ligands and coactivators. J Phys Chem B. 2008 Aug 14;112(32):9603-12. Epub 2008 Jul 23.

We tested 4-hydroxytamoxifen, diethylstilbestrol, chlordane, genistein, daidzein, and biochanin A as ligands.
2(0,0,0,2) Details
10493499 Yang C, Chen S: Two organochlorine pesticides, toxaphene and chlordane, are antagonists for estrogen-related receptor alpha-1 orphan receptor. Cancer Res. 1999 Sep 15;59(18):4519-24.
2(0,0,0,2) Details
11850205 Chen S, Zhou D, Yang C, Okubo T, Kinoshita Y, Yu B, Kao YC, Itoh T: Modulation of aromatase expression in human breast tissue. J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):35-40.

The modulation of aromatase expression by endocrine disrupting chemicals is exemplified by two organochlorine pesticides (i.e. toxaphene and chlordane) that have been found to be antagonists of ERRalpha-1 orphan receptor.
83(1,1,1,3) Details