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chlordane

Identification (Source:EPA,EU)

ID	1474
Name	chlordane
CAS	57-74-9
IUPAC	1,2,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methanoindene
Inchi	InChI=1S/C10H6Cl8/c11-3-1-2-4(5(3)12)9(16)7(14)6(13)8(2,15)10(9,17)18/h2-5H,1H2
CIPAC	13
EPA Code	058201
Formula	C10H6Cl8
SMILES	Cl/C2=C(\Cl)C3(Cl)C1CC(Cl)C(Cl)C1C2(Cl)C3(Cl)Cl
Status	Not Approved

Classification

Mode of Action	Non systemic with contact, stomach and respiratory action. GABA-gated chloride channel antagonist.
Pesticide Type	Insecticide
Chemical Group	Cyclodiene organochlorine
Classification	cyclodiene insecticides

Properties (Source:PubChem)

Molecular Weight	409.78
Physical State	Straw coloured viscous liquid in raw state but powder in product form
AlogP	4.788
H-Bond Donor	0
H-Bond Acceptor	0
Surface Area	302.79
Polar Surface Area	0.0

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Aquatic invertebrates	Acute	48 hour	EC50	0.59 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	0.07 mg l-1
Birds	Acute		LD50	83 mg kg-1
Fish	Acute	96 hour	LC50	0.09 mg l-1
Honeybees	Acute	48 hour	LD50	6.0 μg bee-1
Mammals	Acute oral		LD50	460 mg kg-1
Mammals	Short term dietary		NOEL	5 mg kg-1
Sediment dwelling organisms	Acute	96 hour	LC50	0.01 mg l-1
	Bio-concentration factor		CT50	Not available days
	Bio-concentration factor		BCF	20000

Related targets

Target Name	RScore (About this table)
estrogen receptor	213(2,3,3,23)	Details
estrogen related receptor alpha	180(2,2,2,20)	Details
U82	192(1,4,7,7)	Details
SRBC	114(1,2,2,4)	Details
ras oncogene (protein family or complex)	112(1,2,2,2)	Details
ATPase	98(1,1,3,8)	Details
MC 2	94(1,1,3,4)	Details
Hsp89	85(1,1,1,5)	Details
ERbeta	83(1,1,1,3)	Details
epoxide hydratase	82(1,1,1,2)	Details
Acetylcholinesterase	82(1,1,1,2)	Details
RARbeta	81(1,1,1,1)	Details
ribonuclease	81(1,1,1,1)	Details
CYP17A1	81(1,1,1,1)	Details
MC7	167(0,5,7,7)	Details
calcium channel (protein family or complex)	62(0,2,2,2)	Details
ATPases	50(0,1,4,5)	Details
Connexin 43	40(0,1,1,10)	Details
muscles	39(0,1,1,9)	Details
CYP1A1	38(0,1,1,8)	Details
U83	37(0,1,2,2)	Details
epidermal growth factor	37(0,1,2,2)	Details
CYP2B	34(0,1,1,4)	Details
HSD17B4	33(0,1,1,3)	Details
IFNG	32(0,1,1,2)	Details
immunoglobulin (protein family or complex)	32(0,1,1,2)	Details
transferrin	32(0,1,1,2)	Details
CYP3A	31(0,1,1,1)	Details
HSD17B1	31(0,1,1,1)	Details
CC1	31(0,1,1,1)	Details
cytochrome P450 (protein family or complex)	36(0,0,2,26)	Details
alkaline phosphatase	21(0,0,3,6)	Details
pg m	20(0,0,2,10)	Details

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